NR 566 ADVANCED PHARMACOLOGY CARE OF THE FAMILY QUESTIONS WITH CORRECT ANSWER

NR 566 ADVANCED PHARMACOLOGY CARE OF THE
FAMILY QUESTIONS WITH CORRECT ANSWER




H1 antagonists adverse effects -
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anssedation, dizziness, incoordination, confusion, fatigue, insomnia, tremors, seizures, n/
cx cx cx cx cx cx cx cx cx




v, and anticholinergic effects.
cx cx cx




H! antagonists drug selection -
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ansCNS depression is most prominent in ethanolamine and phenothiazines (least likely in
cx cx cx cx cx cx cx cx cx cx cx cx cx




Alkylamines)

H1 antagonist - Alkylamines -
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ansprovide effective H1 blockade with little reduction in alertness. If excessive sedation co
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ntinues a 2nd generation should be used. cx cx cx cx cx cx




What active ingredient do sleep aides contain? -
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ansall sleep aides contain an H1 antagonist; either diphenhydramine or pyrilamine as its ac
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tive ingredient cx




1st generation vs 2nd generation histamine antagonists -
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ans1) 2nd generation produce much less sedation
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2) 2nd generation crosses blood-brain barrier poorly
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3) 2nd generation has a low affinity for H2 receptors of the CNS
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Food/Drug interactions with Fexofenadine (H2 antagonists)? - cx cx cx cx cx cx




ansFruit juices reduce absorption, which reduce therapeutic effects.
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Patient's should not drink fruit juices 4 HRs before dosing and 2 HRs after dosage
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Glucocorticoids MOA #1 - cx cx cx




ans1) glucocorticoids penetrate the cell membrane and then bind with receptors in the cyto
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plasm, thereby converting the receptor from an inactive form to an active form.
cx cx cx cx cx cx cx cx cx cx cx cx




Glucocorticoids MOA #2 - ans2) receptor- cx cx cx cx cx




steroid complex migrates to the cell nucleus, where it binds to chromatin in DNA, thereby alt
cx cx cx cx cx cx cx cx cx cx cx cx cx cx cx




ering activity of target genes.
cx cx cx cx




Pharmacologic effects of glucocorticoids - metabolism - cx cx cx cx cx cx




ansglucose levels rise, protein synthesis is suppressed, fat deposits are mobilized
cx cx cx cx cx cx cx cx cx cx cx




Pharmacologic effects of glucocorticoids - electrolytes - cx cx cx cx cx cx




anshigh dose can inhibit intestinal absorption of calcium; rarely can induce sodium retentio
cx cx cx cx cx cx cx cx cx cx cx cx cx




n or potassium
cx cx