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HESI PHARMACOLOGY MASTERY: 200 EXAM-READY QUESTIONS WITH CORRECT ANSWERS & RATIONALES FOR NURSING SUCCESS

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Ace Your HESI Pharmacology Exam with This Comprehensive Q-Bank! This 116-page PDF contains 200 expertly-crafted practice questions covering the ENTIRE pharmacology curriculum—from cardiovascular drugs (digoxin, furosemide, warfarin, amiodarone) and antibiotics (vancomycin, gentamicin, doxycycline) to CNS medications, diabetes drugs, respiratory medications, pain management, antineoplastics, antivirals, and emergency antidotes! Each question includes the correct answer AND a detailed, NCLEX-style rationale that explains the mechanism of action, adverse effects, nursing interventions, and patient teaching—so you understand the "why" behind every medication. Perfect for nursing students preparing for HESI, NCLEX-RN, or pharmacology course finals. Topics include: antidotes, drug interactions (grapefruit, St. John's wort), lab monitoring (therapeutic levels, renal function), side effect management, and priority nursing actions. Stop memorizing drug facts—start thinking like a nurse! Save hours of study time with questions designed to build clinical judgment and boost exam scores. BONUS: Covers high-yield topics like serotonin syndrome, digoxin toxicity, anticoagulant reversal, insulin types, and psych meds—exactly what you'll encounter on test day and in clinical practice!

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Institution
HESI PHARMACOLOGY MASTERY: 2
Course
HESI PHARMACOLOGY MASTERY: 2

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HESI Pharmacology Exam 1 (2026/2027) | 100%

Verified Questions & Answers | Latest Updated

2026 | A+ Guaranteed

1. A client takes digoxin 0.25 mg daily. Which finding

suggests digoxin toxicity?

A. Heart rate 72 bpm

B. Yellow-tinged vision

C. Blood pressure 130/80

D. Urine output 50 mL/hr

Answer: B

Rationale: Yellow or halos around vision (xanthopsia) is

classic for digoxin toxicity. Bradycardia, nausea, and

arrhythmias are also signs.

2. A nurse administers furosemide IV. Which lab requires

priority follow-up?

A. Sodium 135 mEq/L

B. Potassium 2.9 mEq/L



1

,C. Glucose 110 mg/dL

D. Creatinine 0.9 mg/dL

Answer: B

Rationale: Hypokalemia (K+ <3.5) increases risk of

arrhythmias and digoxin toxicity. Furosemide is a loop

diuretic causing potassium loss.

3. A client on metoprolol reports dizziness and HR 52

bpm. What is the nurse’s priority?

A. Give the medication as ordered

B. Hold dose and notify provider

C. Increase fluids

D. Administer atropine

Answer: B

Rationale: Beta-blockers should be held if HR <60

(depending on order) and provider notified. Bradycardia

is a common adverse effect.

4. Which instruction is correct for sublingual nitroglycerin?

A. Swallow with full glass of water

2

,B. Take up to 3 doses 5 minutes apart for chest pain

C. Store bottle in refrigerator

D. Discard 6 months after opening

Answer: B

Rationale: Standard: 1 tablet q5min x3 doses for chest

pain. Call 911 if no relief after first dose. Store in

original dark bottle, not refrigerated.

5. A client on amiodarone develops cough and dyspnea.

What does the nurse suspect?

A. Heart failure exacerbation

B. Pulmonary toxicity

C. Beta-blocker effect

D. Allergic reaction

Answer: B

Rationale: Amiodarone causes pulmonary fibrosis. New

cough/dyspnea needs chest X-ray and possibly stopping

the drug.



3

, 6. A client takes lisinopril. Which adverse effect requires

immediate teaching?

A. Dry cough

B. Swelling of tongue and lips

C. Headache

D. Fatigue

Answer: B

Rationale: Angioedema (airway compromise) is a medical

emergency. Dry cough is common but not emergent.

7. A client on warfarin has INR 4.5. No bleeding. What

action is correct?

A. Administer vitamin K immediately

B. Hold next dose and notify provider

C. Give protamine sulfate

D. Increase warfarin dose

Answer: B

Rationale: INR 4.5 is above typical therapeutic range (2-



4

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HESI PHARMACOLOGY MASTERY: 2
Course
HESI PHARMACOLOGY MASTERY: 2

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