MCB 450 Exam 4 Practice UPDATED
QUESTIONS AND CORRECT ANSWERS
The synthesis of glucose from pyruvate by gluconeogenesis:
-Requires the oxidation/reduction of FAD.
-Requires the participation of biotin.
-Occurs exclusively in the cytosol.
-Involves lactate as an intermediate.
-Is inhibited by an elevated level of glucagon. - CORRECT ANSWER Requires the
participation of biotin
Which one of the following is a common intermediate in the conversion of glycerol and lactate to
glucose?
-Glucose 6-phosphate
-Malate
-Oxaloacetate
-Pyruvate
-Phosphoenol pyruvate - CORRECT ANSWER Glucose 6-phosphate
Which one of the following reactions is unique to gluconeogenesis?
-Oxaloacetate to phosphoenolpyruvate
-Lactate to pyruvate
-Phosphoenolpyruvate to pyruvate
-Glucose-6-PO4 to Fructose-6-PO4
-1,3-Bis-phosphoglycerate to 3-phosphoglycerate - CORRECT ANSWER Oxaloacetate to
phosphoenolpyruvate
Which of the following would be expected to occur after acute alcohol ingestion?
,-Lactic acidosis
-The inhibition of ketogenesis
-An increase in NAD/NADH+ ratio
-The activation of fatty acid oxidation
-An increase in gluconeogenesis - CORRECT ANSWER Lactic acidosis
A 34-year-old woman presents to her physician complaining of oral ulcers. A careful history reveals
that she is a strict vegetarian and does not eat meat, fish, poultry, eggs, or dairy products. She is found
to have a severe riboflavin deficiency. The function of which enzymes in the TCA cycle would be
most directly affected by the riboflavin deficiency?
-Isocitrate dehydrogenase
-Succinate dehydrogenase
-Malate dehydrogenase
-Aconitase
-Citrate synthase - CORRECT ANSWER Succinate dehydrogenase
Mammalian pyruvate dehydrogenase complex (PDC) is inactivated by pyruvate dehydrogenase kinase
in the presence of:
-Low Glucagon
-High NADH
-High ADP
-High Insulin
-High Pyruvate - CORRECT ANSWER High NADH
Which lipoprotein particle functions in "reverse" cholesterol transport?
-Chylomicrons
-HDL
-LDL
, -IDL
-VLDL - CORRECT ANSWER HDL
Which of these enzymes is primarily responsible for digesting dietary triacylglycerols in the small
intestine?
-Lipoprotein lipase
-Lingual lipase
-Hormone-sensitive lipase
-Gastric lipase
-Pancreatic lipase - CORRECT ANSWER Pancreatic lipase
High levels of ATP and citrate:
-Inhibit glycolysis.
-Indicate remote gluconeogenesis.
-Indicate a high energy-well fed state.
-All of the above
-None of the above - CORRECT ANSWER All of the above
Which of the following would be associated with HIGH pyruvate dehydrogenase rate?
-High Acetyl CoA
-Low pyruvate
-High NADH
-High ADP
-High ATP - CORRECT ANSWER High ADP
The hallmarks of acute alcoholism without food intake are acidosis and hypoglycemia. These
metabolic changes are due to the:
QUESTIONS AND CORRECT ANSWERS
The synthesis of glucose from pyruvate by gluconeogenesis:
-Requires the oxidation/reduction of FAD.
-Requires the participation of biotin.
-Occurs exclusively in the cytosol.
-Involves lactate as an intermediate.
-Is inhibited by an elevated level of glucagon. - CORRECT ANSWER Requires the
participation of biotin
Which one of the following is a common intermediate in the conversion of glycerol and lactate to
glucose?
-Glucose 6-phosphate
-Malate
-Oxaloacetate
-Pyruvate
-Phosphoenol pyruvate - CORRECT ANSWER Glucose 6-phosphate
Which one of the following reactions is unique to gluconeogenesis?
-Oxaloacetate to phosphoenolpyruvate
-Lactate to pyruvate
-Phosphoenolpyruvate to pyruvate
-Glucose-6-PO4 to Fructose-6-PO4
-1,3-Bis-phosphoglycerate to 3-phosphoglycerate - CORRECT ANSWER Oxaloacetate to
phosphoenolpyruvate
Which of the following would be expected to occur after acute alcohol ingestion?
,-Lactic acidosis
-The inhibition of ketogenesis
-An increase in NAD/NADH+ ratio
-The activation of fatty acid oxidation
-An increase in gluconeogenesis - CORRECT ANSWER Lactic acidosis
A 34-year-old woman presents to her physician complaining of oral ulcers. A careful history reveals
that she is a strict vegetarian and does not eat meat, fish, poultry, eggs, or dairy products. She is found
to have a severe riboflavin deficiency. The function of which enzymes in the TCA cycle would be
most directly affected by the riboflavin deficiency?
-Isocitrate dehydrogenase
-Succinate dehydrogenase
-Malate dehydrogenase
-Aconitase
-Citrate synthase - CORRECT ANSWER Succinate dehydrogenase
Mammalian pyruvate dehydrogenase complex (PDC) is inactivated by pyruvate dehydrogenase kinase
in the presence of:
-Low Glucagon
-High NADH
-High ADP
-High Insulin
-High Pyruvate - CORRECT ANSWER High NADH
Which lipoprotein particle functions in "reverse" cholesterol transport?
-Chylomicrons
-HDL
-LDL
, -IDL
-VLDL - CORRECT ANSWER HDL
Which of these enzymes is primarily responsible for digesting dietary triacylglycerols in the small
intestine?
-Lipoprotein lipase
-Lingual lipase
-Hormone-sensitive lipase
-Gastric lipase
-Pancreatic lipase - CORRECT ANSWER Pancreatic lipase
High levels of ATP and citrate:
-Inhibit glycolysis.
-Indicate remote gluconeogenesis.
-Indicate a high energy-well fed state.
-All of the above
-None of the above - CORRECT ANSWER All of the above
Which of the following would be associated with HIGH pyruvate dehydrogenase rate?
-High Acetyl CoA
-Low pyruvate
-High NADH
-High ADP
-High ATP - CORRECT ANSWER High ADP
The hallmarks of acute alcoholism without food intake are acidosis and hypoglycemia. These
metabolic changes are due to the:
