Questions and Guide Answers
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1. Which if the following findings on the mental status exam of a psychiatric
patient is the strongest predictor of inability to make medical decisions?
A. Lack of insight
B. Poor judgement
C. Suicidal ideation
D. Perceptual disturbances
E. Abnormal thought content
Answer: A
2. Pedigree-based approaches are most powerful for identifying what type of
gene variant?
A. Copy number
,B. Rare high penetrance
C. Simple tandem repeat
D. Common low penetrance
E. Single nucleotide polymorphism
Answer: B
3. Repetitive transcranial magnetic stimulation for the treatment of unipolar
depression targets which of the following brain regions?
A. Ventral striatum
B. Locus coeruleus
C. Periamygdaloid cortex
D. Medial temporal cortex
E. Dorsolateral prefrontal cortex
Answer: E
4. Which of the following cognitive responses to environmental stimuli has
been found to be more characteristic of patients with anxiety disorders when
compared to patients with depression?
A. Misattributions regarding stimuli
B. Hopelessness regarding meaning of stimuli
,C. Automatic negative thoughts toward the stimuli
D. Attentional bias toward potentially threatening stimuli
E. Lack of awareness of physiological responses to stimuli
Answer: D
5. SKIP:
6. Which of the following instructions can enhance hypoactive DTR in the leg?
A. Clench a first
B. Elevate an arm
C. Stare at a distant object
D. Think of moving the limb
E. Sensory stimulation of the opposite limb
Answer: A
7. What is the leading cause of death in persons with severe mental illness?
A. Cancer
B. Suicide
C. Diabetes
D. Accidents
, E. Cardiovascular disease
Answer: E
8. Which of the following medications is most effective for migraine prophylax-
is?
A. Sumitriptan
B. Topiramate
C. Fluoxetine
D. Duloxetine
E. Naproxen
Answer: B
9. Which of the following epigenetic mechanisms inhibits the transcriptional
machinery from accessing DNA and thus leads to decreased gene transcrip-tion?
A. Acetylation
B. Methylation
C. Demethylation
D. Histone modification
E. Chromatin remodeling
Answer: B