Page 1 of 49
22 June 2026
Rosenthal: Lehne's Pharmacotherapeutics for Advanced
Practice Nurses and Physician Assistants PREP EXAM
2026/2027 LATEST EXAM TEST UNDER NEW GUIDELINE 150
QUESTIONS AND CORRECT ANSWERS PERFECT TO PASS
2026 Lehne's Pharmacotherapeutics for Advanced Practice
Nurses and Physician Assistants TEST EXAM
Overview:
This test bank mirrors the actual Lehne’s Pharmacotherapeutics for
Advanced Practice Nurses and Physician Assistants (Rosenthal) exam-style
content, helping learners prepare with realistic, updated, and guideline-based
practice questions. Each item reinforces essential concepts in
pharmacodynamics, pharmacokinetics, drug classifications, therapeutic
decision-making, adverse effects, contraindications, and advanced clinical
prescribing principles — building strong pharmacology knowledge and exam
readiness for advanced practice providers.
Key Features:
✅ 150 verified pharmacotherapeutics practice questions with correct
answers
✅ Based on Rosenthal: Lehne’s Pharmacotherapeutics for Advanced
Practice Nurses and Physician Assistants
✅ Fully updated for the 2026/2027 academic and exam cycle under current
guidelines
✅ A+ structured advanced pharmacology exam prep format for mastery
and review
✅ Covers drug mechanisms, clinical indications, interactions, safety
monitoring, and evidence-based prescribing
✅ Ideal for nurse practitioner students, physician assistant programs, and
advanced pharmacology exam preparation
📘 Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician
Assistants
✅ With 150 realistic questions and correct answers, the LEHNE’S
PHARMACOTHERAPEUTICS PREP EXAM 2026/2027 TESTBANK is a
comprehensive and focused study resource designed to strengthen
pharmacology competence and improve success in advanced practice nursing
and physician assistant coursework and exams.
, Page 2 of 49
22 June 2026
A 30-year-old male patient will begin a three-drug regimen to treat peptic ulcer disease. The
regimen will consist of bismuth subsalicylate, tetracycline, and cimetidine [Tagamet]. The nurse
will include which information when teaching this patient about this drug regimen?
a. Black discoloration of the tongue and stools should be reported immediately.
b. Central nervous system depression and confusion are likely to occur.
c. Decreased libido, impotence, and gynecomastia are reversible side effects.
d. Staining of the teeth may occur and is an indication for discontinuation of these drugs. - correct
answer-ANS: C
Cimetidine has antiandrogenic effects and can cause decreased libido, impotence, and
gynecomastia. These effects are reversible. Black stools and discoloration of the tongue are side
effects associated with bismuth but are not harmful. Central nervous system(CNS) depression and
confusion are not likely. Staining of the teeth associated with tetracycline use occurs only in
developing teeth; it is a problem in children younger than 8 years and in pregnant women because
of this risk to the fetus.
A patient who takes nonsteroidal anti-inflammatory drugs (NSAIDs) for arthritis asks a nurse what
can be done to prevent ulcers. The nurse will recommend asking the provider about using which
medication?
a. Antibiotics
b. Histamine-2 receptor antagonists
c. Proton pump inhibitors
d. Mucosal protectants - correct answer-ANS: C
Patients taking NSAIDs should use proton pump inhibitors for ulcer prophylaxis. The other agents are
not used for prophylaxis.
A patient newly diagnosed with PUD reports taking low-dose aspirin (ASA) for prevention of
cardiovascular disease. The nurse learns that the patient drinks 2 to 3 cups of coffee each day and
has a glass of wine with dinner 3 or 4 nights per week. The patient eats three meals a day. The
nurse will counsel this patient to:
a. change the meal pattern to five or six smaller meals per day.
b. discontinue taking aspirin, because it can irritate the stomach.
c. stop drinking wine or any other alcoholic beverage.
, Page 3 of 49
22 June 2026
d. switch to a decaffeinated coffee and reduce the number of servings. - correct answer-ANS: A
Consumption of five or six smaller meals a day can reduce fluctuations in the intragastric pH, which
may facilitate recovery. ASA should be avoided, along with other NSAIDs except for low-dose ASA
used for the prevention of cardiovascular disease. No hard data implicate alcohol as a contributor to
PUD. No data indicate that caffeine contributes to PUD.
A patient is admitted with lower abdominal pain and nausea. The nurse performing the initial
assessment notes that the patient's abdomen is distended and firm, and hypoactive bowel sounds
are present. The patient has not had a stool for 3 days. The nurse will contact the provider, who
will:
a. order a bulk-forming laxative.
b. order extra fluids and fiber.
c. perform diagnostic tests.
d. prescribe a cathartic laxative. - correct answer-ANS: C
Laxatives are contraindicated for patients with abdominal pain, nausea, cramps, or other symptoms
of abdominal disease or an acute surgical abdomen. Laxatives should not be used in patients with
obstruction or impaction. This patient shows signs of abdominal obstruction, and laxatives could
cause a bowel perforation secondary to increased peristalsis. A bulk-forming laxative is
contraindicated. Patients with acute abdomens should be kept NPO pending diagnosis. A cathartic
laxative is contraindicated.
A patient reports taking an oral bisacodyl laxative [Dulcolax] for several years. The provider has
suggested discontinuing the laxative, but the patient is unsure how to do this. The nurse will tell
the patient to:
a. stop taking the oral laxative and use a suppository until normal motility resumes.
b. stop taking the laxative immediately and expect no stool for several days.
c. switch to a bulk-forming laxative, such as methylcellulose [Metamucil].
d. withdraw from the laxative slowly to avoid a rebound constipation effect. - correct answer-ANS:
B
The first step in breaking the laxative habit is abrupt cessation of laxative use. Bowel movements will
be absent for several days after laxative withdrawal. Using a suppository, a bulk-forming laxative, or
tapering the laxative only prolongs the habit and prevents normal function from returning.
A patient with renal disease is scheduled for a colonoscopy. Before the procedure, the nurse will
anticipate administering:
, Page 4 of 49
22 June 2026
a. glycerin suppository.
b. magnesium hydroxide (MOM).
c. polyethylene glycol and electrolytes.
d. sodium phosphate. - correct answer-ANS: C
Polyethylene glycol (PEG) plus electrolytes (ELS) is one of two bowel cleansers used before
colonoscopy to clear the bowel. PEG-ELS products are preferred, because unlike sodium phosphate,
they are isotonic and do not increase the likelihood of dehydration and electrolyte imbalance.
Glycerin suppositories and magnesium hydroxide are not used for bowel cleansing.
The parent of a child with cerebral palsy reports that the child has pebble-like stools most of the
time and seems uncomfortable if several days have passed between stools. The nurse will suggest
that the parent discuss which medication with the child's provider?
a. Bisacodyl [Dulcolax] suppositories
b. Magnesium citrate
c. Methylcellulose [Citrucel]
d. Polyethylene glycol [MiraLax] - correct answer-ANS: D
Polyethylene glycol is an osmotic laxative widely used for chronic constipation, which this child has,
because it provides relief from abdominal discomfort, improves stool consistency, and increases
frequency. Bisacodyl is not recommended for long-term use. Magnesium citrate causes increased
water loss, and methylcellulose can also cause impaction.
A patient will undergo a colonoscopy, and the provider has ordered sodium phosphate as a bowel
cleanser before the procedure. The nurse reviews the patient's chart and notes that the patient's
creatinine clearance and blood urea nitrogen are both elevated. What will the nurse do?
a. Reduce the amount of fluid given with the laxative to prevent fluid retention.
b. Request an order to give polyethylene glycol and electrolytes (PEG-ELS) instead.
c. Suggest that the patient reduce the dietary sodium intake.
d. Suggest using a suppository laxative instead. - correct answer-ANS: B
PEG-ELS solutions provide an isosmotic solution and do not cause dehydration or electrolyte
imbalance. They are safe to use in patients with renal impairment or cardiovascular disease. This
patient's laboratory values suggest renal impairment. Sodium phosphate products can cause kidney
damage; giving them with less fluid only increases this possibility. Reducing the dietary intake of
sodium is not recommended. Suppositories are not effective bowel cleansing agents.
22 June 2026
Rosenthal: Lehne's Pharmacotherapeutics for Advanced
Practice Nurses and Physician Assistants PREP EXAM
2026/2027 LATEST EXAM TEST UNDER NEW GUIDELINE 150
QUESTIONS AND CORRECT ANSWERS PERFECT TO PASS
2026 Lehne's Pharmacotherapeutics for Advanced Practice
Nurses and Physician Assistants TEST EXAM
Overview:
This test bank mirrors the actual Lehne’s Pharmacotherapeutics for
Advanced Practice Nurses and Physician Assistants (Rosenthal) exam-style
content, helping learners prepare with realistic, updated, and guideline-based
practice questions. Each item reinforces essential concepts in
pharmacodynamics, pharmacokinetics, drug classifications, therapeutic
decision-making, adverse effects, contraindications, and advanced clinical
prescribing principles — building strong pharmacology knowledge and exam
readiness for advanced practice providers.
Key Features:
✅ 150 verified pharmacotherapeutics practice questions with correct
answers
✅ Based on Rosenthal: Lehne’s Pharmacotherapeutics for Advanced
Practice Nurses and Physician Assistants
✅ Fully updated for the 2026/2027 academic and exam cycle under current
guidelines
✅ A+ structured advanced pharmacology exam prep format for mastery
and review
✅ Covers drug mechanisms, clinical indications, interactions, safety
monitoring, and evidence-based prescribing
✅ Ideal for nurse practitioner students, physician assistant programs, and
advanced pharmacology exam preparation
📘 Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician
Assistants
✅ With 150 realistic questions and correct answers, the LEHNE’S
PHARMACOTHERAPEUTICS PREP EXAM 2026/2027 TESTBANK is a
comprehensive and focused study resource designed to strengthen
pharmacology competence and improve success in advanced practice nursing
and physician assistant coursework and exams.
, Page 2 of 49
22 June 2026
A 30-year-old male patient will begin a three-drug regimen to treat peptic ulcer disease. The
regimen will consist of bismuth subsalicylate, tetracycline, and cimetidine [Tagamet]. The nurse
will include which information when teaching this patient about this drug regimen?
a. Black discoloration of the tongue and stools should be reported immediately.
b. Central nervous system depression and confusion are likely to occur.
c. Decreased libido, impotence, and gynecomastia are reversible side effects.
d. Staining of the teeth may occur and is an indication for discontinuation of these drugs. - correct
answer-ANS: C
Cimetidine has antiandrogenic effects and can cause decreased libido, impotence, and
gynecomastia. These effects are reversible. Black stools and discoloration of the tongue are side
effects associated with bismuth but are not harmful. Central nervous system(CNS) depression and
confusion are not likely. Staining of the teeth associated with tetracycline use occurs only in
developing teeth; it is a problem in children younger than 8 years and in pregnant women because
of this risk to the fetus.
A patient who takes nonsteroidal anti-inflammatory drugs (NSAIDs) for arthritis asks a nurse what
can be done to prevent ulcers. The nurse will recommend asking the provider about using which
medication?
a. Antibiotics
b. Histamine-2 receptor antagonists
c. Proton pump inhibitors
d. Mucosal protectants - correct answer-ANS: C
Patients taking NSAIDs should use proton pump inhibitors for ulcer prophylaxis. The other agents are
not used for prophylaxis.
A patient newly diagnosed with PUD reports taking low-dose aspirin (ASA) for prevention of
cardiovascular disease. The nurse learns that the patient drinks 2 to 3 cups of coffee each day and
has a glass of wine with dinner 3 or 4 nights per week. The patient eats three meals a day. The
nurse will counsel this patient to:
a. change the meal pattern to five or six smaller meals per day.
b. discontinue taking aspirin, because it can irritate the stomach.
c. stop drinking wine or any other alcoholic beverage.
, Page 3 of 49
22 June 2026
d. switch to a decaffeinated coffee and reduce the number of servings. - correct answer-ANS: A
Consumption of five or six smaller meals a day can reduce fluctuations in the intragastric pH, which
may facilitate recovery. ASA should be avoided, along with other NSAIDs except for low-dose ASA
used for the prevention of cardiovascular disease. No hard data implicate alcohol as a contributor to
PUD. No data indicate that caffeine contributes to PUD.
A patient is admitted with lower abdominal pain and nausea. The nurse performing the initial
assessment notes that the patient's abdomen is distended and firm, and hypoactive bowel sounds
are present. The patient has not had a stool for 3 days. The nurse will contact the provider, who
will:
a. order a bulk-forming laxative.
b. order extra fluids and fiber.
c. perform diagnostic tests.
d. prescribe a cathartic laxative. - correct answer-ANS: C
Laxatives are contraindicated for patients with abdominal pain, nausea, cramps, or other symptoms
of abdominal disease or an acute surgical abdomen. Laxatives should not be used in patients with
obstruction or impaction. This patient shows signs of abdominal obstruction, and laxatives could
cause a bowel perforation secondary to increased peristalsis. A bulk-forming laxative is
contraindicated. Patients with acute abdomens should be kept NPO pending diagnosis. A cathartic
laxative is contraindicated.
A patient reports taking an oral bisacodyl laxative [Dulcolax] for several years. The provider has
suggested discontinuing the laxative, but the patient is unsure how to do this. The nurse will tell
the patient to:
a. stop taking the oral laxative and use a suppository until normal motility resumes.
b. stop taking the laxative immediately and expect no stool for several days.
c. switch to a bulk-forming laxative, such as methylcellulose [Metamucil].
d. withdraw from the laxative slowly to avoid a rebound constipation effect. - correct answer-ANS:
B
The first step in breaking the laxative habit is abrupt cessation of laxative use. Bowel movements will
be absent for several days after laxative withdrawal. Using a suppository, a bulk-forming laxative, or
tapering the laxative only prolongs the habit and prevents normal function from returning.
A patient with renal disease is scheduled for a colonoscopy. Before the procedure, the nurse will
anticipate administering:
, Page 4 of 49
22 June 2026
a. glycerin suppository.
b. magnesium hydroxide (MOM).
c. polyethylene glycol and electrolytes.
d. sodium phosphate. - correct answer-ANS: C
Polyethylene glycol (PEG) plus electrolytes (ELS) is one of two bowel cleansers used before
colonoscopy to clear the bowel. PEG-ELS products are preferred, because unlike sodium phosphate,
they are isotonic and do not increase the likelihood of dehydration and electrolyte imbalance.
Glycerin suppositories and magnesium hydroxide are not used for bowel cleansing.
The parent of a child with cerebral palsy reports that the child has pebble-like stools most of the
time and seems uncomfortable if several days have passed between stools. The nurse will suggest
that the parent discuss which medication with the child's provider?
a. Bisacodyl [Dulcolax] suppositories
b. Magnesium citrate
c. Methylcellulose [Citrucel]
d. Polyethylene glycol [MiraLax] - correct answer-ANS: D
Polyethylene glycol is an osmotic laxative widely used for chronic constipation, which this child has,
because it provides relief from abdominal discomfort, improves stool consistency, and increases
frequency. Bisacodyl is not recommended for long-term use. Magnesium citrate causes increased
water loss, and methylcellulose can also cause impaction.
A patient will undergo a colonoscopy, and the provider has ordered sodium phosphate as a bowel
cleanser before the procedure. The nurse reviews the patient's chart and notes that the patient's
creatinine clearance and blood urea nitrogen are both elevated. What will the nurse do?
a. Reduce the amount of fluid given with the laxative to prevent fluid retention.
b. Request an order to give polyethylene glycol and electrolytes (PEG-ELS) instead.
c. Suggest that the patient reduce the dietary sodium intake.
d. Suggest using a suppository laxative instead. - correct answer-ANS: B
PEG-ELS solutions provide an isosmotic solution and do not cause dehydration or electrolyte
imbalance. They are safe to use in patients with renal impairment or cardiovascular disease. This
patient's laboratory values suggest renal impairment. Sodium phosphate products can cause kidney
damage; giving them with less fluid only increases this possibility. Reducing the dietary intake of
sodium is not recommended. Suppositories are not effective bowel cleansing agents.
