1|Page
NCLEX PDF Version Updated | NRSG 2350 Exam 2 Practice
Test | Latest 2026 Edition | Practice Questions, Correct
Answers & Detailed Rationales | Comprehensive Nursing
Exam Prep Guide
1. A 65-year-old patient with chronic kidney disease and anemia is
prescribed epoetin alfa. What is the primary indication for this
medication?
A) Treatment of hypertension in renal failure
B) Treatment of anemia associated with renal failure and AIDS
C) Prevention of blood clots in dialysis patients
D) Treatment of iron deficiency anemia
Answer: B) Treatment of anemia associated with renal failure and AIDS
Epoetin alfa (Epogen, Procrit) treats anemia associated with renal failure
and AIDS and decreases the need for blood transfusions in patients
undergoing surgery by stimulating red blood cell production through
erythropoietin receptor activation.
2. A 58-year-old patient with chronic kidney disease on dialysis is
prescribed darbepoetin alfa. What is the primary indication for this
medication?
A) Treatment of iron deficiency anemia
B) Treatment of anemia associated with chronic kidney disease
C) Prevention of venous thrombosis
D) Treatment of sickle cell anemia
Answer: B) Treatment of anemia associated with chronic kidney disease
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Darbepoetin alfa (Aranesp) treats anemia associated with chronic
kidney disease including patients on dialysis by stimulating
erythropoiesis through the erythropoietin receptor, with a longer half-
life allowing less frequent dosing than epoetin alfa.
3. A 45-year-old patient with iron deficiency anemia is prescribed
ferrous sulfate. What is the mechanism of action of ferrous sulfate?
A) Stimulates erythropoietin production
B) Elevates serum iron and converts to hemoglobin or stored for
eventual conversion to usable form of iron
C) Increases vitamin B12 absorption
D) Stimulates bone marrow directly
Answer: B) Elevates serum iron and converts to hemoglobin or stored
for eventual conversion to usable form of iron
Ferrous sulfate elevates serum iron and converts to hemoglobin or is
stored for eventual conversion to usable form of iron, providing the
essential mineral required for red blood cell production and oxygen
transport.
4. A 50-year-old patient taking ferrous sulfate for iron deficiency
anemia asks about medication interactions. Which medication
decreases iron absorption if taken concurrently?
A) Vitamin C
B) Antacids
C) Acetaminophen
D) Insulin
Answer: B) Antacids
Iron absorption decreases if taken with antacids, tetracyclines, or
ciprofloxacin. If needed, these medications should be taken 2 hours
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apart from iron supplements to ensure adequate absorption of both
medications.
5. A 52-year-old patient with iron deficiency anemia is prescribed
ferrous sulfate. Which adverse effect should the patient be warned
about?
A) Insomnia
B) GI disturbances including anorexia, nausea, vomiting, and diarrhea
C) Hypertension
D) Hyperglycemia
Answer: B) GI disturbances including anorexia, nausea, vomiting, and
diarrhea
Ferrous sulfate commonly causes GI disturbances including anorexia,
nausea, vomiting, and diarrhea, and overdose can lead to CNS toxicity
leading to coma and death, requiring careful dosing and monitoring.
6. A 48-year-old patient with iron deficiency anemia who cannot
tolerate oral iron is prescribed iron dextran. What is the most serious
risk associated with parenteral iron therapy?
A) GI bleeding
B) Severe anaphylactic reactions
C) Hypertension
D) Hyperkalemia
Answer: B) Severe anaphylactic reactions
Iron Dextran (Venofer) is associated with severe anaphylactic reactions,
local irritations, and staining of tissues, requiring careful monitoring
during infusion and availability of emergency equipment for potential
reactions.
, 4|Page
7. A 30-year-old patient with sickle cell anemia is prescribed
hydroxyurea. What is the mechanism of action of hydroxyurea in
treating sickle cell anemia?
A) Increases red blood cell production
B) Increases fetal hemoglobin production in the bone marrow and
dilutes formation of abnormal hemoglobin S
C) Prevents sickling of red blood cells
D) Stimulates iron absorption
Answer: B) Increases fetal hemoglobin production in the bone marrow
and dilutes formation of abnormal hemoglobin S
Hydroxyurea (Droxia) increases fetal hemoglobin production in the bone
marrow and dilutes the formation of abnormal hemoglobin S,
decreasing the need for blood transfusions and reducing the frequency
of painful crises in sickle cell disease.
8. A 55-year-old patient on hydroxyurea therapy for sickle cell anemia
should be monitored for which adverse effect?
A) Hypertension
B) Bone marrow depression
C) Hyperglycemia
D) Hyperthyroidism
Answer: B) Bone marrow depression
Hydroxyurea can cause bone marrow depression, along with dizziness,
headache, rash, anorexia, and potential cancer risk, requiring regular
monitoring of complete blood counts during therapy.
NCLEX PDF Version Updated | NRSG 2350 Exam 2 Practice
Test | Latest 2026 Edition | Practice Questions, Correct
Answers & Detailed Rationales | Comprehensive Nursing
Exam Prep Guide
1. A 65-year-old patient with chronic kidney disease and anemia is
prescribed epoetin alfa. What is the primary indication for this
medication?
A) Treatment of hypertension in renal failure
B) Treatment of anemia associated with renal failure and AIDS
C) Prevention of blood clots in dialysis patients
D) Treatment of iron deficiency anemia
Answer: B) Treatment of anemia associated with renal failure and AIDS
Epoetin alfa (Epogen, Procrit) treats anemia associated with renal failure
and AIDS and decreases the need for blood transfusions in patients
undergoing surgery by stimulating red blood cell production through
erythropoietin receptor activation.
2. A 58-year-old patient with chronic kidney disease on dialysis is
prescribed darbepoetin alfa. What is the primary indication for this
medication?
A) Treatment of iron deficiency anemia
B) Treatment of anemia associated with chronic kidney disease
C) Prevention of venous thrombosis
D) Treatment of sickle cell anemia
Answer: B) Treatment of anemia associated with chronic kidney disease
,2|Page
Darbepoetin alfa (Aranesp) treats anemia associated with chronic
kidney disease including patients on dialysis by stimulating
erythropoiesis through the erythropoietin receptor, with a longer half-
life allowing less frequent dosing than epoetin alfa.
3. A 45-year-old patient with iron deficiency anemia is prescribed
ferrous sulfate. What is the mechanism of action of ferrous sulfate?
A) Stimulates erythropoietin production
B) Elevates serum iron and converts to hemoglobin or stored for
eventual conversion to usable form of iron
C) Increases vitamin B12 absorption
D) Stimulates bone marrow directly
Answer: B) Elevates serum iron and converts to hemoglobin or stored
for eventual conversion to usable form of iron
Ferrous sulfate elevates serum iron and converts to hemoglobin or is
stored for eventual conversion to usable form of iron, providing the
essential mineral required for red blood cell production and oxygen
transport.
4. A 50-year-old patient taking ferrous sulfate for iron deficiency
anemia asks about medication interactions. Which medication
decreases iron absorption if taken concurrently?
A) Vitamin C
B) Antacids
C) Acetaminophen
D) Insulin
Answer: B) Antacids
Iron absorption decreases if taken with antacids, tetracyclines, or
ciprofloxacin. If needed, these medications should be taken 2 hours
,3|Page
apart from iron supplements to ensure adequate absorption of both
medications.
5. A 52-year-old patient with iron deficiency anemia is prescribed
ferrous sulfate. Which adverse effect should the patient be warned
about?
A) Insomnia
B) GI disturbances including anorexia, nausea, vomiting, and diarrhea
C) Hypertension
D) Hyperglycemia
Answer: B) GI disturbances including anorexia, nausea, vomiting, and
diarrhea
Ferrous sulfate commonly causes GI disturbances including anorexia,
nausea, vomiting, and diarrhea, and overdose can lead to CNS toxicity
leading to coma and death, requiring careful dosing and monitoring.
6. A 48-year-old patient with iron deficiency anemia who cannot
tolerate oral iron is prescribed iron dextran. What is the most serious
risk associated with parenteral iron therapy?
A) GI bleeding
B) Severe anaphylactic reactions
C) Hypertension
D) Hyperkalemia
Answer: B) Severe anaphylactic reactions
Iron Dextran (Venofer) is associated with severe anaphylactic reactions,
local irritations, and staining of tissues, requiring careful monitoring
during infusion and availability of emergency equipment for potential
reactions.
, 4|Page
7. A 30-year-old patient with sickle cell anemia is prescribed
hydroxyurea. What is the mechanism of action of hydroxyurea in
treating sickle cell anemia?
A) Increases red blood cell production
B) Increases fetal hemoglobin production in the bone marrow and
dilutes formation of abnormal hemoglobin S
C) Prevents sickling of red blood cells
D) Stimulates iron absorption
Answer: B) Increases fetal hemoglobin production in the bone marrow
and dilutes formation of abnormal hemoglobin S
Hydroxyurea (Droxia) increases fetal hemoglobin production in the bone
marrow and dilutes the formation of abnormal hemoglobin S,
decreasing the need for blood transfusions and reducing the frequency
of painful crises in sickle cell disease.
8. A 55-year-old patient on hydroxyurea therapy for sickle cell anemia
should be monitored for which adverse effect?
A) Hypertension
B) Bone marrow depression
C) Hyperglycemia
D) Hyperthyroidism
Answer: B) Bone marrow depression
Hydroxyurea can cause bone marrow depression, along with dizziness,
headache, rash, anorexia, and potential cancer risk, requiring regular
monitoring of complete blood counts during therapy.
