MPJE (Multistate Pharmacy
Jurisprudence Examination)
1. Which federal law established requirements for drug safety and
effectiveness before marketing?
A. Controlled Substances Act
B. Durham-Humphrey Amendment
C. Food, Drug, and Cosmetic Act (FDCA)
D. Kefauver-Harris Amendment
Answer: Food, Drug, and Cosmetic Act (FDCA)
Rationale: The FDCA established federal authority over drug safety, labeling,
and marketing requirements.
2. Which DEA schedule has the highest potential for abuse?
A. Schedule II
B. Schedule III
C. Schedule IV
D. Schedule I
Answer: Schedule I
Rationale: Schedule I substances have the highest abuse potential and no
accepted medical use under federal law.
, 3. A Schedule II prescription may be refilled:
A. Five times in six months
B. Once within 30 days
C. Twice within one year
D. Not at all
Answer: Not at all
Rationale: Federal law prohibits refills for Schedule II controlled substances.
4. Which DEA form is used to order Schedule II controlled substances?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Answer: DEA Form 222
Rationale: DEA Form 222 is required for transferring and ordering Schedule II
controlled substances.
5. The Combat Methamphetamine Epidemic Act regulates the sale of:
A. Opioids
B. Benzodiazepines
C. Pseudoephedrine products
D. Barbiturates
Answer: Pseudoephedrine products
Rationale: The Act restricts pseudoephedrine sales to reduce illicit
methamphetamine production.
, 6. Which DEA form is used to report theft or significant loss of controlled
substances?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Answer: DEA Form 106
Rationale: DEA Form 106 documents theft or significant loss of controlled
substances.
7. Which DEA form is used to register a pharmacy?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Answer: DEA Form 224
Rationale: Pharmacies use DEA Form 224 to obtain or renew DEA registration.
8. The Poison Prevention Packaging Act requires:
A. Tamper-evident packaging
B. Unit-dose packaging
C. Child-resistant packaging
D. Controlled substance packaging
Answer: Child-resistant packaging
, Rationale: The Act helps prevent accidental poisoning in children through special
packaging.
9. Which federal law created Schedule classifications for controlled
substances?
A. FDCA
B. OBRA-90
C. Controlled Substances Act
D. HIPAA
Answer: Controlled Substances Act
Rationale: The CSA established the five schedules of controlled substances.
10.A Schedule III prescription may be refilled:
A. Unlimited times
B. Up to five times within six months
C. Once annually
D. Never
Answer: Up to five times within six months
Rationale: Federal law permits five refills within six months for Schedule III and
IV medications.
11.Which agency enforces controlled substance laws?
A. FDA
B. CDC
C. CMS
D. DEA
Jurisprudence Examination)
1. Which federal law established requirements for drug safety and
effectiveness before marketing?
A. Controlled Substances Act
B. Durham-Humphrey Amendment
C. Food, Drug, and Cosmetic Act (FDCA)
D. Kefauver-Harris Amendment
Answer: Food, Drug, and Cosmetic Act (FDCA)
Rationale: The FDCA established federal authority over drug safety, labeling,
and marketing requirements.
2. Which DEA schedule has the highest potential for abuse?
A. Schedule II
B. Schedule III
C. Schedule IV
D. Schedule I
Answer: Schedule I
Rationale: Schedule I substances have the highest abuse potential and no
accepted medical use under federal law.
, 3. A Schedule II prescription may be refilled:
A. Five times in six months
B. Once within 30 days
C. Twice within one year
D. Not at all
Answer: Not at all
Rationale: Federal law prohibits refills for Schedule II controlled substances.
4. Which DEA form is used to order Schedule II controlled substances?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Answer: DEA Form 222
Rationale: DEA Form 222 is required for transferring and ordering Schedule II
controlled substances.
5. The Combat Methamphetamine Epidemic Act regulates the sale of:
A. Opioids
B. Benzodiazepines
C. Pseudoephedrine products
D. Barbiturates
Answer: Pseudoephedrine products
Rationale: The Act restricts pseudoephedrine sales to reduce illicit
methamphetamine production.
, 6. Which DEA form is used to report theft or significant loss of controlled
substances?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Answer: DEA Form 106
Rationale: DEA Form 106 documents theft or significant loss of controlled
substances.
7. Which DEA form is used to register a pharmacy?
A. DEA Form 41
B. DEA Form 106
C. DEA Form 222
D. DEA Form 224
Answer: DEA Form 224
Rationale: Pharmacies use DEA Form 224 to obtain or renew DEA registration.
8. The Poison Prevention Packaging Act requires:
A. Tamper-evident packaging
B. Unit-dose packaging
C. Child-resistant packaging
D. Controlled substance packaging
Answer: Child-resistant packaging
, Rationale: The Act helps prevent accidental poisoning in children through special
packaging.
9. Which federal law created Schedule classifications for controlled
substances?
A. FDCA
B. OBRA-90
C. Controlled Substances Act
D. HIPAA
Answer: Controlled Substances Act
Rationale: The CSA established the five schedules of controlled substances.
10.A Schedule III prescription may be refilled:
A. Unlimited times
B. Up to five times within six months
C. Once annually
D. Never
Answer: Up to five times within six months
Rationale: Federal law permits five refills within six months for Schedule III and
IV medications.
11.Which agency enforces controlled substance laws?
A. FDA
B. CDC
C. CMS
D. DEA
