2026_2027
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, Climacteric phase The period of endrocrinologic, somatic, and transitory psychologic changes that
occur around the time of menopause.
Early menopause LMP before age 45
Late menopause LMP after age 54
Primary ovarian insufficiency Menopause that occurs before age 40
Early menopause transition (stage -2) Persistent difference of 7 days or more in the length of consecutive cycles.
Late menopause transition (stage -1) 60 or more consecutive days of amenorrhea
Luteal out of phase event (LOOP) Explains why some perimenopausal women have elevated estrogen level
sometimes...In the early menopause transition, elevated FSH levels are adequate to
recruit a second follicle which results in a follicular phase-like rise in estradiol
secretion superimposed on the mid-to-late luteal phase of the ongoing ovulatory
cycle.
Obese women and estradiol levels during menopause Obese women are more likely to have anovulatory cycles with high estradiol levels.
They are also more likely to have lower premenopause yet higher postmenopause
estradiol levels compared with women of normal weight. (why they are at higher risk
of endometrial cancer)
Chinese and Japanese women These ethnic groups have lower estradiol levels then white, black and hispanic
women.
stage +2 late menopause stage: 5-8 years after FMP. Somatic aging predominates.
Increased genitourinary symptoms.
Stages +1a, +1b, +1c early post menopause: 2 years after FMP. FSH rises, estradiol decreases. VMS
predominate.
Elevated FSH, LH Endocrine labs after menopause
AMH, inhibin B These hormones work during reproductive years to not deplete follicle pool too
quickly.
Phases during menopause transition and PMS symptoms Menstrual cycle shortenes, follicular phase compresses, women spend more time in
luteal phase.. meaning more premenstrual symptoms and more frequent menstrual
periods.