NURS 572 Exam 1 | High-Yield Questions and
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What is drug affinity?
Correct Answer:
The strength of attraction between a drug and its receptor
Rationalization:
• High affinity → strong binding → often ↑ potency
• Low affinity → weak binding
Important:
Affinity contributes to potency but does NOT determine efficacy
Question 2
What is the relationship between affinity and potency?
Correct Answer:
Higher affinity generally leads to higher potency
,Rationalization:
Less drug is needed to produce an effect when binding is strong.
Question 3
What is steady state (plateau)?
Correct Answer:
When the amount of drug administered equals the amount eliminated
Question 4
How long does it take to reach steady state?
Correct Answer:
About 4–5 half-lives
Exam Tip:
This is true regardless of dose size
Question 5
What is a loading dose?
Correct Answer:
A large initial dose given to rapidly achieve therapeutic levels
Question 6
What is a maintenance dose?
Correct Answer:
Smaller repeated doses used to maintain steady-state levels
,Question 7
What is the first-pass effect?
Correct Answer:
Rapid hepatic metabolism of a drug after oral administration before reaching systemic
circulation
Rationalization:
• Reduces drug bioavailability
• Important for drugs like nitroglycerin
Question 8
What is the therapeutic objective of drug therapy?
Correct Answer:
To provide maximum benefit with minimum harm
Question 9
What is drug absorption?
Correct Answer:
Movement of a drug from the site of administration into the bloodstream
Question 10
What factors affect absorption?
Correct Answer:
• Surface area
• Blood flow
• Lipid solubility
• pH
, • Drug formulation
Question 11
What is drug distribution?
Correct Answer:
Movement of drugs from the bloodstream into tissues and cells
Question 12
What is drug metabolism?
Correct Answer:
Chemical alteration of a drug, primarily in the liver
Question 13
What is drug excretion?
Correct Answer:
Removal of drugs from the body, primarily via the kidneys
Question 14
Why are children and older adults more sensitive to drugs?
Correct Answer:
Due to immature or declining organ function
Key Points:
• ↓ liver metabolism (elderly)
• ↓ renal function
• Immature BBB in infants
Answers , Clinical Decision-Making, Evidence-
Based & Comprehensive Study Guide| Expert
Guarantee Pass and 100% Accurate | Graded A+ ,
Updated and Reviewed | Latest Exam and Brand
New Version!!!
What is drug affinity?
Correct Answer:
The strength of attraction between a drug and its receptor
Rationalization:
• High affinity → strong binding → often ↑ potency
• Low affinity → weak binding
Important:
Affinity contributes to potency but does NOT determine efficacy
Question 2
What is the relationship between affinity and potency?
Correct Answer:
Higher affinity generally leads to higher potency
,Rationalization:
Less drug is needed to produce an effect when binding is strong.
Question 3
What is steady state (plateau)?
Correct Answer:
When the amount of drug administered equals the amount eliminated
Question 4
How long does it take to reach steady state?
Correct Answer:
About 4–5 half-lives
Exam Tip:
This is true regardless of dose size
Question 5
What is a loading dose?
Correct Answer:
A large initial dose given to rapidly achieve therapeutic levels
Question 6
What is a maintenance dose?
Correct Answer:
Smaller repeated doses used to maintain steady-state levels
,Question 7
What is the first-pass effect?
Correct Answer:
Rapid hepatic metabolism of a drug after oral administration before reaching systemic
circulation
Rationalization:
• Reduces drug bioavailability
• Important for drugs like nitroglycerin
Question 8
What is the therapeutic objective of drug therapy?
Correct Answer:
To provide maximum benefit with minimum harm
Question 9
What is drug absorption?
Correct Answer:
Movement of a drug from the site of administration into the bloodstream
Question 10
What factors affect absorption?
Correct Answer:
• Surface area
• Blood flow
• Lipid solubility
• pH
, • Drug formulation
Question 11
What is drug distribution?
Correct Answer:
Movement of drugs from the bloodstream into tissues and cells
Question 12
What is drug metabolism?
Correct Answer:
Chemical alteration of a drug, primarily in the liver
Question 13
What is drug excretion?
Correct Answer:
Removal of drugs from the body, primarily via the kidneys
Question 14
Why are children and older adults more sensitive to drugs?
Correct Answer:
Due to immature or declining organ function
Key Points:
• ↓ liver metabolism (elderly)
• ↓ renal function
• Immature BBB in infants
