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Acne Rosacea - ANSWER-It develops on the middle third of the face
with hypertrophy and inflammation of the sebaceous glands and is
associated with altered innate immune responses.
Acne Vulgaris - ANSWER-It is the most common skin disease and
occurs primarily between 12 and 25 years old.
R/F: Genetics
P/P: Sebaceous follicles
1) hyper keratinization of the follicular epithelium; (2) altered sebum
production, including hyper seborrhea and dysseborrhea
(3) follicular proliferation of anaerobic Cutibacterium acnes
,Sebaceous follicles cause distention of the thinning of follicular canal
walls and fill with debris (blackheads).
When the follicular wall ruptures, expelling sebum into the
surrounding dermis and initiating inflammation
Noninflammatory -
comedones are open (blackheads)
Inflammatory -
whitehead lesions characterize it (cystic).
Actinic keratoses - ANSWER-Aberrant proliferation of epidermal
keratinocytes from sun exposure, and are pink, red, or brownish
patches, papules, or plaques.
AKs precursor for SCC
Acute Infectious Diarrhea - ANSWER-Associated with viral or bacterial
gastroenteritis from contaminated food or water.
Viruses include rotaviruses, noroviruses, and adenoviruses, COVID-19
,C. difficile is often associated with previous antibiotic therapy.
E. Coli and Shiga Toxin causes HUS
Alcohol Effects on Liver - Cirrhois and Hepatitis - ANSWER-Hepatic fat
storage, toxic effects of alcohol metabolism in the liver, immunologic
alterations, inflammatory cytokines, oxidative stress from lipid
peroxidation, malnutrition, and an ongoing cycle of liver injury and
regeneration. Alcohol is transformed to acetaldehyde; excessive
amounts are toxic and significantly alter hepatocyte function and
activate hepatic stellate cells, a primary cell involved in liver fibrosis.
Alcoholic Hepatitis - ANSWER-Alcoholic steatohepatitis
P/P: Fat storage, inflammation, and degeneration and necrosis of
hepatocytes with infiltration of neutrophils and lymphocytes
Allergic Contact Dermatitis - ANSWER-Delayed hypersensitivity
reaction to contact with the allergen is a T-cell-mediated
Type IV Hypersensitivity - Immune Response
Patch testing is the gold standard for diagnosis.
Ankylosing spondylitis - ANSWER-P/P: Vertebral bodies lose their
concave anterior contour and appear square (Less lordosis and more
Kyphosis)
, S/S: low back pain and stiffness, insidious onset, improvement with
exercise, no improvement with rest, and pain at night with
improvement upon arising.
Hallmark: Enthesitis with chronic inflammation, including CD4 and
CD8 T lymphocytes and macrophagesHLA (HLA-B27)
Complications: chronic pain, disability, aortic regurgitation, pulmonary
fibrosis, cauda equina syndrome, mood disorders.
Appendicitis - ANSWER-Most common in children 10 to 11 years of
age, up to 19
Most common surgical emergency in the abdomen
10 cases per 10,000 persons
RLQ pain, low-grade fever, nausea, rebound tenderness at McBurney's
point.
P/P: Inflammation of the vermiform appendix, which is a projection
from the apex of the cecum, becomes hypoxic
Atopic Eczema - ANSWER-Atopic Dermatitis