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\MBS 650
A 45-year-old man has a mild heart attack and a history of
vascular disease. He is placed on a Mediterranean diet and statin
drug therapy. Which of the following will be the most likely result
of this drug therapy?
Low blood LDLs
A 45-year-old man is found to have an elevated serum triglycerides
of > 730mg/dL. He tells you he forgot to fast before his visit and
he ate a full breakfast of bacon and eggs before the labs were
drawn. Which of the following lipoproteins would be the largest
contributors to a
measurement of plasma triglycerides in this situation?
Chylomicrons and VLDLs
,In the reaction catalyzed by cholesterol ester transfer protein
(CETP), the VLDL particle receives which of the following
compounds from HDL particles?
Cholesterol-ester
In reverse cholesterol transport HDL interacts with the ABCA1
transporter to move cholesterol from the cell to the HDL. This
also requires the activity of which of the following enzyme?
Lecithin cholesterol acyltransferase (LCAT)
HDL particles interact with VLDL particles to exchange
cholesterol ester for triacylglyerols. Which of the following
enzymes is responsible for this process?
Cholesterol ester transfer protein (CETP)
Which of the following is a major source of extracellular
cholesterol for human tissues?
LDLs
,An individual is suspected of having a deficiency in branched chain
keto acid dehydrogenase. Supplementation of which of the
following
vitamins or cofactors may help resolve this issue?
Thiamine
A 55-year old man presents to his primary care physician with
bouts of dizziness and confusion. He is diagnosed with
hyperhomocysteinemia due to a deficiency of cystathionine-ß
synthase. In this individual which of the following amino
acids could potentially become essential?
Cysteine
Phenylketonuria can be caused by an enzymatic deficiency or it
can
present due to a deficiency in which of the following required
metabolic cofactors?
Tetrahydrobiopterin (BH4)
A 17-year old female presents to her primary care and is
diagnosed with a Vitamin B12 (cobalamin) deficiency. In this
individual, which of the
following reactions would be compromised?
Conversion of methyl malonyl-Co A to succinyl-CoA
, A 15-year-old female presents to her pediatrician with concerns
over her inability to sleep, increased feelings of depression and
generalized fatigue. A full laboratory work-up is ordered and
based on these findings she is diagnosed with a melatonin
deficiency. Based on this
information, metabolism of which of the following amino acids is
likely impaired?
Tryptophan
A 52-year- old male sought medical help complaining about
progressive appearance of hyperchromic (hyper pigmented)
papules on the edge of the second finger of both hands. He
also complained about darkening of urine. Incisional biopsy
of one of the spots on his
hands and urine sample tested positive for or homogentisic
acid. Based on these findings a diagnosis of alkaptonuria is
made. This diagnosis is consistent with a deficiency in which of
the following enzymes?
Homogentisate oxidase
Methotrexate is a potent anticancer agent that starves dividing
cells of deoxyribonucleotides through direct inhibition of which of
the following processes?
Metabolism of folic acid