BIO332 Problem Set 3 -
Professor Ellis
Genetics (Massachusetts
College of Pharmacy and
Health Sciences)
, Module 3: Cytogenetics and Chromosome Defects
Problem Set 3
1) Consider the following pair of homologous chromosomes. One is wildtype and the
other contains an inversion:
Is this a pericentric inversion or paracentric inversion?
Draw the inversion loop that forms during prophase I of meiosis.
Now, assume there is a crossing over event that occurs between (6) and (7). Draw the
chromosomes that follow this crossing over event.
2) Fill out the chart below.
Cytogenetic Notation Indicate Affected Common Name
Chromosome and the Type
of Aneuploidy
Trisomy 18 in a female Edward Syndrome
47, XX, +21
X chromosome disomy Klinefelter Syndrome
X chromosome monosomy
46, XX, del(5p)
Professor Ellis
Genetics (Massachusetts
College of Pharmacy and
Health Sciences)
, Module 3: Cytogenetics and Chromosome Defects
Problem Set 3
1) Consider the following pair of homologous chromosomes. One is wildtype and the
other contains an inversion:
Is this a pericentric inversion or paracentric inversion?
Draw the inversion loop that forms during prophase I of meiosis.
Now, assume there is a crossing over event that occurs between (6) and (7). Draw the
chromosomes that follow this crossing over event.
2) Fill out the chart below.
Cytogenetic Notation Indicate Affected Common Name
Chromosome and the Type
of Aneuploidy
Trisomy 18 in a female Edward Syndrome
47, XX, +21
X chromosome disomy Klinefelter Syndrome
X chromosome monosomy
46, XX, del(5p)
