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ATI RN Comprehensive Predictor Practice Exam Questions And Answers Plus Rationales 2026 | Instant Pdf Download

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This ATI RN Comprehensive Predictor Practice Exam 2026 provides a 200-question practice test designed to evaluate readiness for the NCLEX-RN and the ATI Comprehensive Predictor assessment. Each question includes detailed rationales grounded in evidence-based practice, covering the full spectrum of nursing content: medical-surgical nursing (heart failure, COPD, stroke, DVT, pneumonia), pharmacology (warfarin, digoxin, insulin, heparin, lithium), maternal-newborn care, pediatrics, mental health (bipolar disorder, schizophrenia, depression), leadership and delegation, emergency and critical care, infection control, and Next Generation NCLEX (NGN)-style prioritization. This resource builds clinical judgment, test-taking confidence, and content mastery—ideal for nursing students and educators seeking comprehensive preparation for proctored comprehensive exams and licensure success.

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ATI RN Comprehensive Predictor Practice
Exam Questions And Answers Plus
Rationales 2026 | Instant Pdf Download
1. A nurse is caring for four clients. Which client should the nurse

see first?

A. A client with COPD and SpO₂ 89% on 2 L/min oxygen via nasal

cannula

B. A client post-appendectomy day 2 with a temperature of 38.3°C

(101°F)

C. A client with heart failure and 3+ pitting edema

D. A client with new-onset confusion and a bounding pulse

Answer: D
Rationale: New-onset confusion with a bounding pulse suggests

hypercapnia or fluid overload affecting cerebral perfusion. This acute
change in neurological status is always the priority, even over stable vital

sign abnormalities.

2. A charge nurse is making client assignments on a medical-surgical

unit. Which client should be assigned to the Licensed Practical Nurse

(LPN)?

A. A client 1 hour post-cardiac catheterization with bleeding at the

insertion site

,B. A client with stable diabetes mellitus requiring insulin administration

and foot care

C. A client newly admitted with a stroke and altered mental status
D. A client receiving IV heparin with a PTT of 98 seconds

Answer: B

Rationale: LPNs can administer insulin, perform stable wound care, and
monitor stable clients. Options A, C, and D require RN assessment

(bleeding, neurological changes, critical lab monitoring).

3. A nurse is caring for a client with heart failure who reports

sudden shortness of breath, cough with pink, frothy sputum, and

anxiety. Vital signs: BP 168/94, HR 118, RR 32, SpO₂ 84% on 2 L/min

via nasal cannula. Which of the following actions should the nurse

take first? (Select all that apply.)
A. Place the client in high-Fowler’s position

B. Increase oxygen to 100% via non-rebreather mask

C. Administer IV furosemide as prescribed

D. Prepare for endotracheal intubation

E. Notify the healthcare provider

F. Start a second IV line

Answer: A, B, C

Rationale: High-Fowler’s position improves lung expansion and reduces
venous return (A). The client is severely hypoxemic at 84% SpO₂, so

high-flow oxygen via non-rebreather mask is essential (B). IV furosemide

,reduces preload and pulmonary congestion (C). Intubation is not a first

action unless non-invasive measures fail.

4. A nurse is preparing to administer a blood transfusion to a client.
Which IV solution is compatible with packed red blood cells?

A. Lactated Ringer’s solution

B. 5% Dextrose in water (D5W)
C. 0.9% Normal saline

D. 0.45% Normal saline

Answer: C

Rationale: Only 0.9% normal saline is compatible with blood products.

Dextrose solutions can cause hemolysis, and Lactated Ringer’s contains

calcium that can cause clotting.

5. A nurse is caring for a client with a new prescription for
enoxaparin (Lovenox). Which route of administration is correct?

A. Intramuscular

B. Subcutaneous

C. Intravenous push

D. Oral

Answer: B

Rationale: Enoxaparin is a low-molecular-weight heparin administered

subcutaneously, typically in the abdomen. The air bubble in the prefilled

syringe should not be expelled.

, 6. A client with a history of atrial fibrillation is taking warfarin. The

nurse notes an INR of 4.8. The client has no signs of bleeding. What

should the nurse anticipate?
A. Administer vitamin K orally

B. Hold the next dose of warfarin

C. Transfuse fresh frozen plasma
D. Increase the warfarin dose

Answer: B

Rationale: For an asymptomatic client with an INR of 4.8, the standard

of care is to hold the next dose of warfarin and monitor the INR. Vitamin

K is typically reserved for INR >5.0 or active bleeding.

7. A nurse is assessing a client with suspected appendicitis. Which

finding is most specific?
A. Rebound tenderness in the left lower quadrant

B. Pain that starts in the epigastrium and migrates to the right lower

quadrant

C. Fever and chills

D. Nausea and vomiting before the onset of pain

Answer: B

Rationale: Classic appendicitis presents with periumbilical or epigastric

pain that later localizes to McBurney’s point (right lower quadrant). This
migratory pain pattern is highly specific.

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