NURS 8022 Advanced Nursing Practice, NURS 8022,
Complete Exam 2 Questions and Answers, 2026 Exam
Preparation Study Guide
Introduction
This document contains complete Exam 2 questions and
answers for NURS 8022, covering advanced nursing concepts,
hematology, erythropoiesis, anemia disorders, inflammation,
immunity, infection processes, stress responses, HIV, blood
transfusion reactions, and hypersensitivity reactions. It also
includes detailed explanations of pathophysiology, laboratory
findings, immune system functions, and clinical
manifestations relevant to advanced nursing practice. The
material is organized in a question-and-answer format to
support exam preparation and review. It serves as a
comprehensive study resource aligned with major topics
commonly tested in NURS 8022.
Exam Questions and Answers
Fibrin--- correct precise answer ---Protein threads that form
the basis of a blood clot
Formed from fibrinogen during the clotting of blood
prothrombin, thrombin, thrombin, fibrinogen, fibrin--- correct
precise answer ---_________ is the clotting factor that is
,synthesized in the liver in the presence of vitamin K and
converted to _________ during coagulation
________ is the enzyme that converts precursor clotting factor
__________ (synthesized in the liver) to __________
Sequence of events for blood clot formation--- correct precise
answer ---1. Injury to the blood vessel wall or to the blood
induces the formation of prothrombin activator
2. Prothrombin activator changes prothrombin to thrombin
3. Thrombin changes fibrinogen to fibrin
4. Clot retraction occurs assisted by platelets - expresses
serum
▪ Serum is plasma minus clotting factors (fibrinogen)
- "plasma can clot, serum cannot"
Thrombotic Thrombocytopenic Purpura (TTP)--- correct
precise answer ---Thrombotic microangiopathy (damage to
microvasculature)
- Platelets aggregate, form microthrombi, and cause occlusion
of arterioles and capillaries --> widespread ischemia
- genetic predisposition
- large vWf = increased platelet adhesion
- Manifestations: fever, purpura, altered LOC,
thrombocytopenia, hemolytic anemia
,- fatal if plasmapheresis is not immediately initiated
Hemolytic uremic syndrome (HUS)--- correct precise answer -
--Same patho as TTP; related to diarrheal illnesses
- more common in children
Essential (primary) thrombocythemia (ET)--- correct precise
answer ---- Thrombocythemia = platelets >600,000
- Myeloproliferative disorder of platelet precursor cells
▪ Megakaryocytes in bone marrow are produced in excess
- Microvascular thrombosis occurs
- Manifestations:
▪ Often asymptomatic
▪ Often occurs in tandem with inflammatory disease
▪ Can occur with polycythemia vera
Immune (idiopathic) thrombocytopenic purpura (ITP)---
correct precise answer ---Chronic form has IgG autoantibody
that targets platelet glycoproteins
- Antibody-coated platelets are sequestered and removed from
the circulation
Acute form often develops after a viral infection
- One of the most common childhood bleeding disorders
, Manifestations:
▪ Petechiae (small red dots) and purpura (purple blood spots
or skin hemorrhages) progressing to major hemorrhage
Labs:
▪ Decreased platelets with normal bone marrow in absence of
other causes
Disseminated Intravascular Coagulation (DIC)--- correct
precise answer ---Acquired disorder in which clotting and
hemorrhage simultaneously occur
widespread thrombosis occurs - widespread ischemia,
infarction, and organ hypoperfusion
Signs and symptoms:
▪ Bleeding from venipuncture sites, arterial lines
▪ Purpura, petechia, hematomas
▪ Symmetric cyanosis of fingers and toes
▪ Signs of multisystem and/or end organ failure
Sickle Cell--- correct precise answer ---Classified as hemolytic
anemia
Autosomal recessive; mutation of beta globin chain of hgb
resulting in defective hgb
Complete Exam 2 Questions and Answers, 2026 Exam
Preparation Study Guide
Introduction
This document contains complete Exam 2 questions and
answers for NURS 8022, covering advanced nursing concepts,
hematology, erythropoiesis, anemia disorders, inflammation,
immunity, infection processes, stress responses, HIV, blood
transfusion reactions, and hypersensitivity reactions. It also
includes detailed explanations of pathophysiology, laboratory
findings, immune system functions, and clinical
manifestations relevant to advanced nursing practice. The
material is organized in a question-and-answer format to
support exam preparation and review. It serves as a
comprehensive study resource aligned with major topics
commonly tested in NURS 8022.
Exam Questions and Answers
Fibrin--- correct precise answer ---Protein threads that form
the basis of a blood clot
Formed from fibrinogen during the clotting of blood
prothrombin, thrombin, thrombin, fibrinogen, fibrin--- correct
precise answer ---_________ is the clotting factor that is
,synthesized in the liver in the presence of vitamin K and
converted to _________ during coagulation
________ is the enzyme that converts precursor clotting factor
__________ (synthesized in the liver) to __________
Sequence of events for blood clot formation--- correct precise
answer ---1. Injury to the blood vessel wall or to the blood
induces the formation of prothrombin activator
2. Prothrombin activator changes prothrombin to thrombin
3. Thrombin changes fibrinogen to fibrin
4. Clot retraction occurs assisted by platelets - expresses
serum
▪ Serum is plasma minus clotting factors (fibrinogen)
- "plasma can clot, serum cannot"
Thrombotic Thrombocytopenic Purpura (TTP)--- correct
precise answer ---Thrombotic microangiopathy (damage to
microvasculature)
- Platelets aggregate, form microthrombi, and cause occlusion
of arterioles and capillaries --> widespread ischemia
- genetic predisposition
- large vWf = increased platelet adhesion
- Manifestations: fever, purpura, altered LOC,
thrombocytopenia, hemolytic anemia
,- fatal if plasmapheresis is not immediately initiated
Hemolytic uremic syndrome (HUS)--- correct precise answer -
--Same patho as TTP; related to diarrheal illnesses
- more common in children
Essential (primary) thrombocythemia (ET)--- correct precise
answer ---- Thrombocythemia = platelets >600,000
- Myeloproliferative disorder of platelet precursor cells
▪ Megakaryocytes in bone marrow are produced in excess
- Microvascular thrombosis occurs
- Manifestations:
▪ Often asymptomatic
▪ Often occurs in tandem with inflammatory disease
▪ Can occur with polycythemia vera
Immune (idiopathic) thrombocytopenic purpura (ITP)---
correct precise answer ---Chronic form has IgG autoantibody
that targets platelet glycoproteins
- Antibody-coated platelets are sequestered and removed from
the circulation
Acute form often develops after a viral infection
- One of the most common childhood bleeding disorders
, Manifestations:
▪ Petechiae (small red dots) and purpura (purple blood spots
or skin hemorrhages) progressing to major hemorrhage
Labs:
▪ Decreased platelets with normal bone marrow in absence of
other causes
Disseminated Intravascular Coagulation (DIC)--- correct
precise answer ---Acquired disorder in which clotting and
hemorrhage simultaneously occur
widespread thrombosis occurs - widespread ischemia,
infarction, and organ hypoperfusion
Signs and symptoms:
▪ Bleeding from venipuncture sites, arterial lines
▪ Purpura, petechia, hematomas
▪ Symmetric cyanosis of fingers and toes
▪ Signs of multisystem and/or end organ failure
Sickle Cell--- correct precise answer ---Classified as hemolytic
anemia
Autosomal recessive; mutation of beta globin chain of hgb
resulting in defective hgb
