NR 566 ADVANCED PHARMACOLOGY FOR THE CARE
OF THE FAMILY: WEEK 1 ANTIFUNGAL AGENTS
Amphotericin B is a _________ antibiotic
is it well absorbed in the GI tract?
polyene
no; poorly absorbed. PO therapy won't work. must be given IV!
undergoes binding to sterol-containing membranes of tissues
Amphotericin B must be given __
IV
Amphotericin B should be used in _______ ___________ ________
_________ impairment occurs in all pts
life threatening infections
Renal
when it comes to ____________ _, kidney damage = total dose in tx
amphotericin B
,highly nephrotoxic
if Amphotericin B dose > _ g, permanent damage is likely to occur, can be decreased by
infusing 1 L of saline
4
if plasma creatinine is > ____, decrease dose
3.5
high levels of Itraconazole can cause fatal __________ ____________
if taking ____________ and ____________: monitor levels!
ventricular dysrhythmias
digoxin, cyclosporine
if taking Itraconazole with __________: PT time should be monitored! can be _______
by azoles
if taking Itraconazole with _____________: check blood sugar can be ________ by
azoles, causing severe hypoglocemia
warfarin; increased
sulfonylureas; increased
itraconazole is a ______ spectrum ____________
, Azoles are often used as alternatives to _____________ _ for most systemic fungal
infections, systemic and superficial mycoses
broad
antifungal
Amphotericin B
old people have higher risk for ___________, decreasing ability to absorb antifungal
meds.
achlorhydria (no gastric acid in stomach)
Do not take Itraconazole with meds that raise gastric pH: __________, __ ________,
____
antacids, H2 antagonists, PPIs
these meds can decrease the absorption of Itraconazole
Caspofungin is a ___________
often used in __ form
echinocandin
IV
OF THE FAMILY: WEEK 1 ANTIFUNGAL AGENTS
Amphotericin B is a _________ antibiotic
is it well absorbed in the GI tract?
polyene
no; poorly absorbed. PO therapy won't work. must be given IV!
undergoes binding to sterol-containing membranes of tissues
Amphotericin B must be given __
IV
Amphotericin B should be used in _______ ___________ ________
_________ impairment occurs in all pts
life threatening infections
Renal
when it comes to ____________ _, kidney damage = total dose in tx
amphotericin B
,highly nephrotoxic
if Amphotericin B dose > _ g, permanent damage is likely to occur, can be decreased by
infusing 1 L of saline
4
if plasma creatinine is > ____, decrease dose
3.5
high levels of Itraconazole can cause fatal __________ ____________
if taking ____________ and ____________: monitor levels!
ventricular dysrhythmias
digoxin, cyclosporine
if taking Itraconazole with __________: PT time should be monitored! can be _______
by azoles
if taking Itraconazole with _____________: check blood sugar can be ________ by
azoles, causing severe hypoglocemia
warfarin; increased
sulfonylureas; increased
itraconazole is a ______ spectrum ____________
, Azoles are often used as alternatives to _____________ _ for most systemic fungal
infections, systemic and superficial mycoses
broad
antifungal
Amphotericin B
old people have higher risk for ___________, decreasing ability to absorb antifungal
meds.
achlorhydria (no gastric acid in stomach)
Do not take Itraconazole with meds that raise gastric pH: __________, __ ________,
____
antacids, H2 antagonists, PPIs
these meds can decrease the absorption of Itraconazole
Caspofungin is a ___________
often used in __ form
echinocandin
IV
