QUESTIONS COMPLETE WITH VERIFIED
ANSWERS AND DETAILED RATIONALES
1. A 58-year-old male with COPD exacerbation is on a 40% Venturi mask. ABG: pH
7.31, PaCO2 68, PaO2 62, HCO3- 32. What is the most appropriate next step?
A. Increase FiO2 to 60%
B. Initiate noninvasive ventilation (NIV)
C. Intubate and mechanically ventilate
D. Administer sodium bicarbonate
Correct Answer: B
Rationale: The patient has acute-on-chronic respiratory acidosis (pH <7.35, PaCO2
elevated with elevated HCO3- indicating chronic compensation). NIV is first-line
for acute exacerbation of COPD if not in extremis. No immediate need for
intubation (no hemodynamic instability, severe hypoxemia, or inability to protect
airway). Sodium bicarbonate not indicated. Increasing FiO2 alone does not
address hypoventilation.
2. A patient with severe asthma is intubated. Ventilator settings: PRVC, rate 14, Vt
450 mL, PEEP 5, FiO2 0.8. Plateau pressure = 38 cmH2O. What is the priority?
A. Increase Vt to 500 mL
B. Decrease Vt to 350 mL
C. Increase PEEP to 10
D. Switch to pressure control
Correct Answer: B
Rationale: Plateau pressure >30 cmH2O increases risk of barotrauma and
,ventilator-induced lung injury. In asthma, high plateau pressures are usually due
to dynamic hyperinflation or auto-PEEP. Lowering tidal volume (Vt) reduces
plateau pressure. Increasing PEEP could worsen hyperinflation. Pressure control
may not lower plateau pressure without lowering Vt.
3. A 72-year-old post-op day 2 from CABG develops acute hypoxemic respiratory
failure. CXR: bilateral opacities, no cardiomegaly. PAOP is 12 mmHg. What is the
best initial ventilatory strategy?
A. Low tidal volume (6 mL/kg IBW) with PEEP >5
B. High tidal volume (10 mL/kg) with low PEEP
C. Spontaneous breathing trial
D. Inverse ratio ventilation
Correct Answer: A
Rationale: Likely ARDS (bilateral opacities, PAOP ≤18, acute onset). ARDSnet low
tidal volume ventilation (6 mL/kg ideal body weight) with moderate to high PEEP
reduces mortality. High tidal volume worsens lung injury. Spontaneous breathing
trial inappropriate for acute hypoxemia. Inverse ratio not first-line.
4. A patient on pressure support (PS) 10, PEEP 5, FiO2 0.4 triggers every breath
but has a rapid shallow breathing index (RSBI) of 105. What should the RT
recommend?
A. Extubate immediately
B. Continue weaning with lower PS
C. Return to full ventilator support
D. Perform a cuff leak test
Correct Answer: C
Rationale: RSBI >105 suggests high likelihood of weaning failure. Continuing
weaning increases risk of respiratory muscle fatigue and reintubation. Return to
full support and address cause (e.g., secretions, heart failure, weakness). Cuff leak
test assesses upper airway edema, not weaning readiness.
,5. Which ABG finding is most consistent with compensated metabolic alkalosis?
A. pH 7.48, PaCO2 50, HCO3- 34
B. pH 7.36, PaCO2 60, HCO3- 36
C. pH 7.40, PaCO2 40, HCO3- 24
D. pH 7.31, PaCO2 30, HCO3- 18
Correct Answer: A
Rationale: Metabolic alkalosis (high HCO3-) with respiratory compensation
(PaCO2 increases) to normalize pH. Expected compensation: PaCO2 = 0.7 × HCO3-
+ 20 ± 5. Here 0.7×34+20=43.8, actual 50 is close. pH slightly alkalemic but near
normal.
6. A 45-year-old with pneumonia on volume-controlled ventilation (Vt 450, rate
16, PEEP 8, FiO2 0.6) has SpO2 88%. ABG: PaO2 55. What change is most
effective?
A. Increase rate to 20
B. Increase PEEP to 14
C. Increase Vt to 600
D. Change to pressure control
Correct Answer: B
Rationale: Hypoxemia on FiO2 0.6 indicates need for increased mean airway
pressure. Increasing PEEP recruits alveoli and improves oxygenation. Increasing
rate may worsen auto-PEEP. Increasing Vt raises plateau pressure and risk of VILI.
Changing mode alone does not address oxygenation.
7. A patient with Guillain-Barré syndrome has decreasing vital capacity (from 18 to
10 mL/kg) and maximal inspiratory pressure (MIP) -20 cmH2O. What is indicated?
A. Noninvasive ventilation
B. Immediate intubation
, C. Chest physiotherapy
D. High-flow nasal cannula
Correct Answer: B
Rationale: Guillain-Barré with rapidly declining vital capacity (<15 mL/kg) and MIP
less negative than -30 cmH2O indicates risk of acute respiratory failure. Immediate
intubation is needed because neuromuscular weakness can progress quickly to
apnea. NIV not safe due to bulbar weakness and aspiration risk.
8. Which of the following is a contraindication to noninvasive ventilation (NIV)?
A. COPD exacerbation with pH 7.32
B. Cardiogenic pulmonary edema
C. Facial burns with copious secretions
D. Obesity hypoventilation syndrome
Correct Answer: C
Rationale: Absolute contraindications to NIV include facial burns/trauma, copious
thick secretions, inability to protect airway, hemodynamic instability, and
decreased mental status. COPD exacerbation (pH >7.25-7.30) often benefits from
NIV. Cardiogenic pulmonary edema and obesity hypoventilation are indications.
9. A patient on APRV with P high 30, P low 0, T high 4.0 sec, T low 0.6 sec has
spontaneous breaths but end-expiratory flow does not return to zero. What
should be adjusted?
A. Increase T low
B. Decrease P high
C. Decrease T high
D. Increase P low
Correct Answer: A
Rationale: In APRV, if end-expiratory flow does not reach zero before next P high,
there is incomplete exhalation (auto-PEEP). Increase T low to allow more