pharmacology - Answers study of drugs
drug - Answers Chemical that affects physiologic process of a living organism
Nursing Implications - Answers The concepts that a nurse must include when they are safely
administering medication
Identify the various routes of medication administration - Answers Sublingual (buccal), oral,
transdermal (topical creams/ lotions), instillation (eye drops/sprays), inhalation, nasogastric and
gastrostomy tubes, suppositories, parenteral
6 rights of administration - Answers 1. Right patient
2. Right drug
3. Right dose
4. Right route
5. Right time and frequency
6. Right documentation
List the components of a drug label - Answers Chemical Name: structure of the drug
Generic name: the official drug name
Brand/ trade name: the easier proprietary name
Active and inactive ingredients
Warning/ possible side effects
Directions on use as well as what the drug is used for/ what it helps treat
normal vital signs (BP) - Answers 120/80
Pharmacokinetics - Answers what the body does to the drug
pharmacokinetic phases - Answers -absorption (drug movement from GI tract into bloodstream)
-distribution (protein binding, free drugs, BBB)
-metabolism (1/2 life, loading dose; liver)
-excretion (elimination, kidneys, creatinine clearance, BUN, GFR
factors that affect drug excretion - Answers -drugs that affect renal excretion/decrease CO
-diuretic use
-drugs that use same excretion method
-change of urine pH
-pt. with decreased renal or hepatic function
1/2 life (T 1/2) - Answers Time it takes to get rid of half of the drug; gives us good time to administer
rest of the dose and when we can expect to see side effects
Loading dose - Answers use of a higher dose than what is usually used for treatment to allow the
drug to reach the critical concentration sooner
photosensitivity - Answers - sensitivity to light
- ranges from the ability to orient to the sun to the ability to see
factors affecting absorption - Answers Blood circulation
Pain, stress
Food texture, fat content, temperature
pH
Route of administration
factors affecting bioavailability - Answers Drug form
Route of administration (IV is best)
Gastric mucosa and motility
Administration with food and other drugs
Changes in liver metabolism
what can affect absorption - Answers Blood circulation, pain, stress, pH, administration route, and
food texture, fat content, and temperature
What is bioavailability? - Answers The percentage of administered drug available for activity.
what can affect bioavailability - Answers The form of the drug, route of administration, gastric
mucosa and motility, administration with food and other drugs, and changes in liver metabolism
affect it.
what metabolizes drugs - Answers liver
what excretes drugs - Answers kidneys
, what impacts drug excretion - Answers drugs that affect renal excretion, drugs that decrease cardiac
output, diuretics, drugs that compete, urine pH, and decreased renal/ hepatic function
pharmacodynamics - Answers what the drug does to the body
pharmacodynamics phases - Answers receptor binding, postreceptor effects, chemical reaction
primary response - Answers desirable response
secondary response - Answers desirable or undesirable response
potency - Answers amount of drug needed to get a response most of the time
therapeutic index - Answers relationship between therapeutic and toxic dose
onset - Answers Time it takes drug to reach minimum effective concentration
peak - Answers highest concentration in blood
trough - Answers point of lowest concentration of the drug (drawn before next dose is to be
administered)
duration - Answers length of time taken for the drug to exert a therapeutic affect
non-specific receptors - Answers affect multiple sites (if one is targeted all will be targeted)
non-selective receptors - Answers affect multiple receptors (beta, alpha, etc.)
Antagonist - Answers Prevent receptor activation (blocks the response); one drug blocks/reduces
effects of other drug
agonist - Answers Activate receptors to produce a desired response
additive - Answers Sum of effects of two drugs
synergistic - Answers Effect is much greater than effects of drugs alone
pharmacogenetics - Answers Genetic understanding of how drugs may impact one person differently
than someone else
side effects - Answers desirable or undesirable; secondary drug effects
placebo effect - Answers drug response not attributed to chemical drug properties
toxic - Answers drug level exceeds therapeutic range
what is the fastest therapeutic route for meds - Answers IV
normal lab values- electrolytes (K) - Answers 3.5-5.0mEq/L
normal lab values- electrolytes (Na) - Answers 136-145mEq/L
normal lab values- chemistry (BUN) - Answers 10-20mg/dL
normal lab values- chemistry (serum creatinine) - Answers 0.5-1.3mg/DI
normal lab values- chemistry (ALP) - Answers 30-120 units/L
normal lab values- chemistry (ALT) - Answers 4-36 units/L
normal lab values- chemistry (AST) - Answers 0-35 units/L
how many times should you read the drug label - Answers 3 times
competencies - Answers patient-family-centered care, collaboration and teamwork, evidence-based
practice, quality improvement, safety, and informatics
reporting med errors - Answers Make sure the client is safe
Notify your immediate supervisor
Check for adverse drug reporting
Identify your responsibility for external reporting
U.S. Pharmacopeia Medication Errors Reporting Program
just culture - Answers encourages individuals to report drug errors with the goal to repair the system.
Identify key ethical concepts for pharmacotherapy. - Answers -informed consent: pt has right to be
informed; voluntary participation
-autonomy: right to self-determination
-beneficence: protecting the client from harm
-justice: selection of research subjects is fair
-respect for persons:
-ethical rights: right assessment, pt right to education, right evaluation, pt right to refuse
Tuskegee Experiment - Answers without consent, African American men were exposed to syphilis
which exposed their wives who gave birth to infants with defects; no informed consent was given
Nuremberg Trials - Answers after World War II, in which Nazi leaders were tried for aggression,
violations of the rules of war, and crimes against humanity; Allowed the right to be informed and that
participation is voluntary
Thalidomide - Answers European patients who took thalidomide during the first trimester of
pregnancy to help their nausea, gave birth to infants with extreme limb deformities