What site in the nephron is impermeable to water and reabsorbs Na, K, and Cl?
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Thick ascending limb of the loop of Henle
How does HSV or VZV confer resistance to guanosine analogs?
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Mutation in the viral thymidine kinase enzyme
, Guanosine analog would not be phosphorylated and thus cannot inhibit viral
DNA polymerase.
Lysosomes in hepatocytes of patients with Inclusion cell disease (mucolipidosis II)
contain abnormal enzyme activities resulting from an inability of these cells to do what?
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Synthesize mannose-6-phosphate residues on proteins
Failure of Golgi-based post-translational modification of ptoteolytic enzymes
that would typically be targeted to the lysosome.
Proteases targeted to the lysosomes are tagged with phosphate at the 6th
carbon on their mannose residues -> mannose 6 phosphate. Defective N
acetylglucosaminyl 1 phosphotransferase enzymes are unable to join
phosphate onto mannose residues. causing the synthesized proteases t be
abnormally routed into vesicles for exocytosis intense o the lysosome.
Bacillus anthracis causes anthrax. Describe the pathogen?
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Gram-positive rod
Facultative anaerobe
Arranges in chains on microscopy
,Nonsmoker woman with a chronic consolidation in the periphery of the lung. What is the
diagnosis and classical histologic findings?
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Adenocarcinoma of the lung
Glandular pattern with mucin-positive stain
What type of hypersensitivity is Graves disease?
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Type II
Thyroid-stimulating antibodies that activate the TSH receptor
What are examples of medications with zero-order elimination kinetics?
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Alcohol
Aspirin
Phenytoin
, What is the function of human chorionic gonadotropin?
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Maintain the corpus luteum and continue its production of progesterone.
Critical in maintaining the pregnancy through the first 8-10 weeks when
placenta is not yet producing its own progesterones.
What lung cancer is associated with hypercalcemia and why?
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Squamous Cell Carcinoma
Because of paraneoplastic parathyroid hormone-related peptide (PTHrP)
production
In aortic stenosis, what would the cardiac pressure tracing reveal?
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Large pressure gradient between the left ventricle and aorta
Give this one a try later!
Thick ascending limb of the loop of Henle
How does HSV or VZV confer resistance to guanosine analogs?
Give this one a try later!
Mutation in the viral thymidine kinase enzyme
, Guanosine analog would not be phosphorylated and thus cannot inhibit viral
DNA polymerase.
Lysosomes in hepatocytes of patients with Inclusion cell disease (mucolipidosis II)
contain abnormal enzyme activities resulting from an inability of these cells to do what?
Give this one a try later!
Synthesize mannose-6-phosphate residues on proteins
Failure of Golgi-based post-translational modification of ptoteolytic enzymes
that would typically be targeted to the lysosome.
Proteases targeted to the lysosomes are tagged with phosphate at the 6th
carbon on their mannose residues -> mannose 6 phosphate. Defective N
acetylglucosaminyl 1 phosphotransferase enzymes are unable to join
phosphate onto mannose residues. causing the synthesized proteases t be
abnormally routed into vesicles for exocytosis intense o the lysosome.
Bacillus anthracis causes anthrax. Describe the pathogen?
Give this one a try later!
Gram-positive rod
Facultative anaerobe
Arranges in chains on microscopy
,Nonsmoker woman with a chronic consolidation in the periphery of the lung. What is the
diagnosis and classical histologic findings?
Give this one a try later!
Adenocarcinoma of the lung
Glandular pattern with mucin-positive stain
What type of hypersensitivity is Graves disease?
Give this one a try later!
Type II
Thyroid-stimulating antibodies that activate the TSH receptor
What are examples of medications with zero-order elimination kinetics?
Give this one a try later!
Alcohol
Aspirin
Phenytoin
, What is the function of human chorionic gonadotropin?
Give this one a try later!
Maintain the corpus luteum and continue its production of progesterone.
Critical in maintaining the pregnancy through the first 8-10 weeks when
placenta is not yet producing its own progesterones.
What lung cancer is associated with hypercalcemia and why?
Give this one a try later!
Squamous Cell Carcinoma
Because of paraneoplastic parathyroid hormone-related peptide (PTHrP)
production
In aortic stenosis, what would the cardiac pressure tracing reveal?
Give this one a try later!
Large pressure gradient between the left ventricle and aorta
