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Exam (elaborations)

NBME 31 100 Verified Questions with Standards-Based Explanations

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NBME 31 100 Verified Questions with Standards-Based Explanations

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BRCA gene mutation inheritance


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AD




Albendazole moa


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Alteration of the cytoskeleton by binding to tubulin -> inhibits microtubule
polymerization

,Embryonal carcinoma


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- Poorly differentiated cells with pleomorphic, high-grade nuclear features
and displaying solid, glandular or papillary arrangements




Long-chain acyl CoA dehydrogenase deficiency


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- AR
- Accumulation of long-chain fatty acids in the mitochondrial matrix
- Irritiability, lethargy, hepatomegaly and hypoglycemia
- Symptoms triggered by illness, fasting, stress or exercise
- Hypoglycemia without ketones because dec. in acyl CoA from long chain
fatty acids




Theophylline is meatbolized by


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CYP450




Pain at costovertebral angle vs pain at groin

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Angle = pyelonephritis
Groin = calculus at ureterovesical junction




Kissing bugs transmit


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Trypansoma cruzi -> chagas disease




Branches of gastroduodenal


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- Right gastroepiploic (pyloric end of greater curvature of stomach)

- Superior pancreaticoduodenal arteries (head of pancreas)




Cysteine's structure


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, Sulfhydryl moiety plays an important structural role in tertiary and higher
structures of proteins
- Forms disfulfide bridges that connects two separate areas of the
polypeptide chain




M2 antagonist mechanism


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Inc. HR
Inr. conduction velocity
No effect on forve of contraction




Fungal cell wall is made of


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Glucans, chitin and glycoproteins




Wernicke encaphalopathy brain lesion


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Atrophy of mammillary bodies and medial dorsal nucleus

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