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Urinary and Fluid/Electrolytes/Acid/Base Balance Case Studies | Answered 100% Latest updated 2026/2027. American Sentinel University at Post

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Urinary and Fluid/Electrolytes/Acid/Base Balance Case Studies | Answered 100% Latest updated 2026/2027. Part 1 Case 1: A 54-year-old female complains of a “burning” when urinating x 2 days. She shared, “I feel like I have to pee every 60 minutes or so.” She denies suprapubic/back pain and fever. Past medical history: high cholesterol, high blood pressure. Medications: atorvastatin for cholesterol. Allergies: Penicillin (skin rash). Physical examination: temperature 98.8°F; pulse 80 bpm; respirations 14 per minute; blood pressure 114/68 mmHg. Examination unremarkable; no suprapubic or costovertebral angle tenderness. Urine dipstick reveals moderate leukocytes and positive nitrites, with all other values within normal limits. Part 2 – Please complete all of Part 2. A 46-year-old female is asymptomatic and has a routine urinalysis as part of her annual physical. The urinalysis with microscopy report is as follows: Part 3– Please complete only one case from Part 3. Only one case is required. Hematuria (blood in the urine) is common and can be due to benign conditions (e.g., strenuous exercise) or serious disorders (e.g., renal cell carcinoma). Review these cases and determine the most likely cause of hematuria. Discuss data that supports your decision as well as diagnostic and treatment strategies. Case 1: A 50-year-old White male is complaining of right-sided flank pain that started about 3 hours ago. He describes the pain as sharp and intermittent. He notes that his urine is a bit darker, but he denies seeing blood. The pain started after he finished mowing a client’s lawn (he is a landscaper). He denies dysuria, urgency, or fever. Past medical history: gout. Medications: allopurinol 100 mg orally every day. Allergies: no known drug allergies (NKDA). Social history: denies smoking, alcohol use, or drug misuse. Physical examination: temperature 98.7°F; pulse 94 bpm; respirations 18 per minute; blood pressure 140/88 mmHg. General: anxious, holding right side, and moving around; otherwise, examination is unremarkable. Part 4 – Complete all of Part 4. A 15-year-old male complains of a sore throat persisting x 3 days. After 1 day, he developed fatigue, fever, and nausea. Throat culture: presence of group A beta-hemolytic streptococci. The child was then started on antibiotic therapy. Symptoms gradually improved, but 10 days later, he returned with fever, nausea, and malaise. He became SOB and tachypneic. The caregiver noted that his eyes were swollen, his ankles were puffy, and his urine was cloudy and dark. Physical exam: BP was 144/98 mmHg; pulse 118 bpm; and respirations 30 per minute. Orbital/ankle edema were +. Crackles were auscultated bilaterally. Negative for heart murmurs. Slight tenderness to percussion over the flank areas was noted. A chest X-ray indicated congestion bilaterally. Hematocrit 37%,; WBC count 11,200/mm3. Blood urea nitrogen (BUN) 46 mg/dL (normal is 20 mg/dL). Urinalysis results showed that the client’s protein was 2+ (24-hour excretion was 0.8 g), specific gravity was 1.012, and there were moderate amounts of RBCs and WBCs in the urine. Serum albumin was 4.1 g/dL (normal is 3.5–4.5). Fluid/Electrolytes and Acid/Base Balance Part 1– Please complete two cases (of your choosing) from Part 1. Only two cases are required. The following activity includes several case presentations of edema. Make a diagnosis for each case, remembering the following questions: ● What medications are the client taking? ● Is the edema acute/sudden or chronic (e.g., duration, progression)? Is it unilateral or bilateral? ● Is the edema generalized or localized? Is it pitting or nonpitting? Is it dependent? ● In addition to edema, what other characteristics are associated with the edema (e.g., redness, pain)? What is the pertinent past or coexisting medical history? Activity: Identify the probable diagnosis and what data support your decision. ● Describe the pathogenesis for the diagnosis. ● What data is inconsistent with your diagnosis? ● What diagnostic tests would you order, if any, and how would you treat this client? Note: Assume “within normal limits” history/examination if not listed. Case 1: A 47-year-old female complains of intermittent, mild bilateral feet/ankle swelling x 45 days, worse on the L leg, especially after prolonged standing. She denies pain, but states her legs feel “heavy” at times and reports standing for long periods worsens the swelling. For the past 10 months, she has been experiencing intermittent numbness in both feet. She also reports her R knee has been “achy”. She is a server at a restaurant and often works 8-10-hour days. She denies any warmth, trauma, fever, or erythema. Past medical history: obesity (BMI 30); diabetes mellitus type 2. Medications: metformin (diabetes). Case 2: A 67-year-old male complains of R leg swelling x 2 weeks. The swelling began while he was traveling. The swelling is intermittent and below the knee all the way to his foot. He describes a cramp-like pain in his R calf. Recently, both legs have been cramping upon ambulation, and resolves upon rest. He denies trauma, warmth, fever, or erythema. Past medical history: dyslipidemia; iliofemoral deep vein thrombosis (DVT) of his R leg after he had R hip replacement for osteoarthritis 8 months ago; treated with rivaroxaban x 6 months; stable angina; obesity (BMI 31.1). Social history: ceased smoking 6 years ago, resumed 1/4 pack per day x 6 months ago. Medications: metoprolol; simvastatin; aspirin. Physical examination: vital signs within normal limits; L leg is within normal limits except hairless, shiny skin; R leg 1+ pitting edema in the pretibial area/foot; mild pain with R calf compression, one small tortuous vein on the medial aspect of calf; R leg is hairless and shiny. A venous duplex Doppler ultrasound of his left leg was done and is negative. Part 2 – Complete all of Part 2. A 71-year-old female was treated for pneumonia with antibiotics. After 1 week on antibiotics, she started developing severe diarrhea of approximately 6 loose stools/day x 3 days. She has decreased appetite, feels nauseous, and has not been drinking a lot of fluids. She feels very weak and dizzy. She lives alone. She is diagnosed with diarrhea, presumptive Clostridium difficile. Client medical history: Clostridium difficile 1 year prior. Physical examination: temperature 99.0°F; pulse 100 bpm; respirations 24 bpm; and blood pressure 90/50 mmHg (decreased to 72/42 mmHg while sitting). Examination: dry mucous membranes and generalized mild abdominal tenderness upon palpation. Laboratory findings reveal: Chemistry panel: sodium 135 mEq/L; potassium 3.4 mEq/L; chloride 100 mmol/L; HCO3- 12 mEq/L; blood urea nitrogen 40 mg/dL. Creatinine: 1.2 mg/dL. ABG: pH 7.22, PaO2 85 mmHg, PaCO2 20 mmHg, HCO3- 12 mEq/L

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Urinary and Fluid/Electrolytes/Acid/Base Balance
Case Studies Instructions
Urinary Function


Part 1– Please complete only one case (of your choosing) from Part 1. Only
one case is required.


Case 1: A 54-year-old female complains of a “burning” when urinating x 2 days. She shared, “I
feel like I have to pee every 60 minutes or so.” She denies suprapubic/back pain and fever.

Past medical history: high cholesterol, high blood pressure.
Medications: atorvastatin for cholesterol.
Allergies: Penicillin (skin rash).

Physical examination: temperature 98.8°F; pulse 80 bpm; respirations 14 per minute; blood
pressure 114/68 mmHg.

Examination unremarkable; no suprapubic or costovertebral angle tenderness.

Urine dipstick reveals moderate leukocytes and positive nitrites, with all other values within
normal limits.

1. What is the most likely diagnosis?

The most likely diagnosis is acute uncomplicated cystitis, which is a lower urinary tract
infection (Bono & Leslie, 2025; Dlugasch & Story, 2023).

2. Which pathogen is likely causing this disorder?

The most common causative organism for uncomplicated cystitis is Escherichia coli (E.
coli), responsible for approximately 80–90% of cases in women (Bono & Leslie, 2025).

3. What is the likely mode of transmission? Discuss data that support your decision.

The likely mode of transmission is ascending infection from the urethra, where perineal
or gastrointestinal flora enter the urinary tract. This diagnosis is supported by:

● Dysuria
● Increased urinary frequency
● Positive nitrites – indicates gram-negative organisms such as E. coli

, ● Moderate leukocyte esterase – inflammation/infection
● Afebrile, no CVA tenderness – suggests lower, not upper, UTI

This presentation aligns with diagnostic criteria for acute uncomplicated cystitis (Bono &
Leslie, 2025; Nicolle et al., 2019).

4. What diagnostic test, if any, should be done?

A urine dipstick plus clinical history is often sufficient for diagnosis. However, a urine
culture is recommended if symptoms persist, recur, or if treatment failure occurs. It may
also be used to guide antibiotic choice due to resistance patterns (Nicolle et al., 2019).

5. What are diagnostic test findings would support your diagnosis?

If a urine culture is performed, the expected diagnostic findings for
acute uncomplicated cystitis include growth of ≥100,000 colony-
forming units per milliliter (CFU/mL) of a single uropathogen—most
commonly Escherichia coli—along with an antibiotic susceptibility
panel to help guide treatment and ensure appropriate antimicrobial
selection (Bono & Leslie, 2025; Nicolle et al., 2019). These findings
support both the diagnosis and stewardship-based treatment
decisions, which are emphasized in current U.S. clinical practice
guidelines.

6. Develop a treatment plan for this client.

Given the patient’s symptoms and urinalysis findings, treatment should follow current
recommendations for acute uncomplicated cystitis. According to U.S. clinical guidelines,
nitrofurantoin 100 mg twice daily for five days is a preferred first-line option since it is
effective against E. coli and has relatively low resistance rates (Nicolle et al., 2019 ).
Another appropriate option is trimethoprim–sulfamethoxazole (TMP–SMX), but only if
local resistance is known to be below 20% and there is no sulfa allergy (Nicolle et al.,
2019 ). Fosfomycin 3 g as a single oral dose is also supported in the literature and may
be useful when adherence to a multi-day regimen could be an issue (Bono & Leslie,
2025).

In addition to antibiotics, patient education is key. I would encourage adequate hydration,
remind the patient to void after sexual activity, and explain the importance of completing
the full antibiotic course even if symptoms improve early. It’s also important to review
warning signs such as fever, flank pain, or worsening symptoms, which may indicate
possible progression to pyelonephritis. For short-term symptom relief, phenazopyridine
could be used, but only as an adjunct—not a substitute—for antimicrobial
treatment(Bono & Leslie, 2025; Dlugasch & Story, 2023 ). I would recommend follow-
up if symptoms do not improve within 48–72 hours or if systemic symptoms develop.

References

, Bono, M. J., & Leslie, S. W. (2025). Uncomplicated urinary tract infections. In Statpearls

[internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK470195/

Dlugasch, L., & Story, L. (2023). Applied pathophysiology for the advanced practice nurse

(2nd ed.). Jones & Bartlett Learning.

Nicolle, L. E., Gupta, K., Bradley, S. F., Colgan, R., DeMuri, G. P., Drekonja, D., Eckert,

L. O., Geerlings, S. E., Köves, B., Hooton, T. M., Juthani-Mehta, M., Knight, S. L.,

Saint, S., Schaeffer, A. J., Trautner, B., Wullt, B., & Siemieniuk, R. (2019). Clinical

practice guideline for the management of asymptomatic bacteriuria: 2019 update by

the infectious diseases society of America. Clinical Infectious Diseases, 68(10), e83–

e110. https://doi.org/10.1093/cid/ciy1121




Part 2 – Please complete all of Part 2.

A 46-year-old female is asymptomatic and has a routine urinalysis as part of her annual physical.
The urinalysis with microscopy report is as follows:

Urinalysis, complete Result WNL Reference Range
Color Dark yellow Yellow
Appearance Cloudy Clear
Specific gravity 1.023 1.001–1.035
pH ≤ 5.0 5.0–8.0
Glucose Negative (-) Negative (-)
Bilirubin Negative (-) Negative (-)
Ketones Negative (-) Negative (-)
Occult blood 1+ Negative (-)
Protein Negative (-) Negative (-)
Nitrite Negative (-) Negative (-)
Leukocyte esterase Negative (-) Negative (-)
White blood cells None seen ≤ 5 /HPF
Red blood cells 0–2 ≤ 2 /HPF

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