NR507 ADVANCED PATHOPHYSIOLOGY WEEK 1 EXAM CHAMBERLAIN UNIVERSITY
NR507 ADVANCED PATHOPHYSIOLOGY WEEK
1 EXAM CHAMBERLAIN UNIVERSITY EXAM
QUESTIONS AND ANSWERS WITH RATIONALE
2026
Focuses on
a) Altered Immune System
b) Inflammation
c) Hypersensitivity Disorders.
d) Immunodeficiency
Common topics include:
Week 1 Topics
1. Innate vs. Adaptive Immunity
o First-line vs. specific immune defenses
o B cells, T cells, antibodies
2. Inflammation
o Acute vs. chronic inflammation
o Chemical mediators (histamine, cytokines, prostaglandins)
o Signs of inflammation
3. Hypersensitivity Reactions (Types I–IV)
o Type I: IgE-mediated (anaphylaxis, allergies)
o Type II: Cytotoxic
o Type III: Immune complex
o Type IV: Delayed T-cell mediated
4. Autoimmune Disorders
o Loss of self-tolerance
o Examples: Lupus, Rheumatoid Arthritis, Graves Disease
5. Immunodeficiency Disorders
o Primary vs. secondary immunodeficiency
o HIV/AIDS pathophysiology
6. Transplant Rejection & Alloimmunity
o Hyperacute, acute, and chronic rejection
o Graft-versus-host disease
, NR507 ADVANCED PATHOPHYSIOLOGY WEEK 1 EXAM CHAMBERLAIN UNIVERSITY
1. Which cell is the primary antigen-presenting cell responsible for initiating
adaptive immunity?
A. Neutrophil
B. Eosinophil
C. Dendritic cell
D. Basophil
Answer: C
Rationale: Dendritic cells process antigens and present them to T lymphocytes, serving as the
critical link between innate and adaptive immunity.
2. A patient develops wheezing and hypotension within minutes of receiving
penicillin. This reaction is classified as:
A. Type I hypersensitivity
B. Type II hypersensitivity
C. Type III hypersensitivity
D. Type IV hypersensitivity
Answer: A
Rationale: Type I reactions are IgE-mediated and occur immediately after exposure to an
allergen.
3. Which inflammatory mediator is primarily responsible for vasodilation during
acute inflammation?
A. Histamine
B. Albumin
C. Hemoglobin
D. Insulin
Answer: A
Rationale: Histamine released from mast cells causes vasodilation and increased capillary
permeability.
NR507 ADVANCED PATHOPHYSIOLOGY WEEK
1 EXAM CHAMBERLAIN UNIVERSITY EXAM
QUESTIONS AND ANSWERS WITH RATIONALE
2026
Focuses on
a) Altered Immune System
b) Inflammation
c) Hypersensitivity Disorders.
d) Immunodeficiency
Common topics include:
Week 1 Topics
1. Innate vs. Adaptive Immunity
o First-line vs. specific immune defenses
o B cells, T cells, antibodies
2. Inflammation
o Acute vs. chronic inflammation
o Chemical mediators (histamine, cytokines, prostaglandins)
o Signs of inflammation
3. Hypersensitivity Reactions (Types I–IV)
o Type I: IgE-mediated (anaphylaxis, allergies)
o Type II: Cytotoxic
o Type III: Immune complex
o Type IV: Delayed T-cell mediated
4. Autoimmune Disorders
o Loss of self-tolerance
o Examples: Lupus, Rheumatoid Arthritis, Graves Disease
5. Immunodeficiency Disorders
o Primary vs. secondary immunodeficiency
o HIV/AIDS pathophysiology
6. Transplant Rejection & Alloimmunity
o Hyperacute, acute, and chronic rejection
o Graft-versus-host disease
, NR507 ADVANCED PATHOPHYSIOLOGY WEEK 1 EXAM CHAMBERLAIN UNIVERSITY
1. Which cell is the primary antigen-presenting cell responsible for initiating
adaptive immunity?
A. Neutrophil
B. Eosinophil
C. Dendritic cell
D. Basophil
Answer: C
Rationale: Dendritic cells process antigens and present them to T lymphocytes, serving as the
critical link between innate and adaptive immunity.
2. A patient develops wheezing and hypotension within minutes of receiving
penicillin. This reaction is classified as:
A. Type I hypersensitivity
B. Type II hypersensitivity
C. Type III hypersensitivity
D. Type IV hypersensitivity
Answer: A
Rationale: Type I reactions are IgE-mediated and occur immediately after exposure to an
allergen.
3. Which inflammatory mediator is primarily responsible for vasodilation during
acute inflammation?
A. Histamine
B. Albumin
C. Hemoglobin
D. Insulin
Answer: A
Rationale: Histamine released from mast cells causes vasodilation and increased capillary
permeability.
