natural history of disease
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The natural history of a disease refers to the progression and outcome of
the disease without medical intervention. Knowledge of the natural history
can be used to determine disease outcome, establish services, and
compare the results of treatments with the expected outcome without
treatment. The causation, etiology, and morbidity are all parts that are
necessary in understanding the natural history of the disease.
Drug P is an agonist with relative selectivity for beta 2 receptors. What clinical effects
are likely to occur? Why?
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, Drug P is an agonist with relative selectivity for beta 2 receptors. What
clinical effects are likely to occur? Why?
Drug M has an ED50 of 20mg and TD50 of 2000mg. A maximal drug response will
occur in all people at 80mg. Is a starting dose of 80mg in all people reasonable?
Why?
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Yes, at 80mg all people will experience the maximal effect of the drug. This
drug is very safe, and we only begin to see toxicity at 2000mg
What triggers might lead to increased intracellular calcium
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• Ischemia
toxins
How will you monitor for the development of serotonin syndrome in clinical practice
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, Be aware of potential drug-drug interactions. Assess for over-the-counter
medication that may cause serotonin syndrome. Ask about use of
substance such as MDMA, methamphetamine. Assess patients for
confusion, mood changes, agitation, altered level of consciousness, fever,
blood pressure instability, tachycardia, and neurological symptoms (see
slide #21).
Can registered nurses who are authorized to prescribe schedule 1 drugs refill a
prescription for testosterone? Hydromorphone? Ramipril?
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RN: No to testosterone and hydromorphone (federal restrictions); Yes to
ramipril (if and only if the RN has authority to prescribe an part of an
approved algorithm).
cell kill hypothesis
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a theoretical model that predicts the ability of antineoplastic drugs to
eliminate cancer cells.
This hypothesis predicts that a drug will kill a certain percentage, rather
than a constant number, of cancer cells
How does dependence differ from addiction
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, Dependence refers to behaviors that continue despite negative
consequences. In physical dependence, removal of the agent results in
symptoms of withdrawal.
Psychological dependence (i.e., addiction) is not associated with physical
discomfort after discontinuation. It refers to intense craving and compulsive
use.
nonREM sleep
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i. stage 1- onset of sleep 1-7m
ii. stage 2 - deeper 10-25m
iii. stage 3 - deep sleep few minutes
iv. stage 4 - deep sleep 20-40m
Which type of pharmacotherapeutic agent uses an herbal product to produce a
desired clinical effect?
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natural health product
Are there tertiary prevention programs? Examples?
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Give this one a try later!
The natural history of a disease refers to the progression and outcome of
the disease without medical intervention. Knowledge of the natural history
can be used to determine disease outcome, establish services, and
compare the results of treatments with the expected outcome without
treatment. The causation, etiology, and morbidity are all parts that are
necessary in understanding the natural history of the disease.
Drug P is an agonist with relative selectivity for beta 2 receptors. What clinical effects
are likely to occur? Why?
Give this one a try later!
, Drug P is an agonist with relative selectivity for beta 2 receptors. What
clinical effects are likely to occur? Why?
Drug M has an ED50 of 20mg and TD50 of 2000mg. A maximal drug response will
occur in all people at 80mg. Is a starting dose of 80mg in all people reasonable?
Why?
Give this one a try later!
Yes, at 80mg all people will experience the maximal effect of the drug. This
drug is very safe, and we only begin to see toxicity at 2000mg
What triggers might lead to increased intracellular calcium
Give this one a try later!
• Ischemia
toxins
How will you monitor for the development of serotonin syndrome in clinical practice
Give this one a try later!
, Be aware of potential drug-drug interactions. Assess for over-the-counter
medication that may cause serotonin syndrome. Ask about use of
substance such as MDMA, methamphetamine. Assess patients for
confusion, mood changes, agitation, altered level of consciousness, fever,
blood pressure instability, tachycardia, and neurological symptoms (see
slide #21).
Can registered nurses who are authorized to prescribe schedule 1 drugs refill a
prescription for testosterone? Hydromorphone? Ramipril?
Give this one a try later!
RN: No to testosterone and hydromorphone (federal restrictions); Yes to
ramipril (if and only if the RN has authority to prescribe an part of an
approved algorithm).
cell kill hypothesis
Give this one a try later!
a theoretical model that predicts the ability of antineoplastic drugs to
eliminate cancer cells.
This hypothesis predicts that a drug will kill a certain percentage, rather
than a constant number, of cancer cells
How does dependence differ from addiction
Give this one a try later!
, Dependence refers to behaviors that continue despite negative
consequences. In physical dependence, removal of the agent results in
symptoms of withdrawal.
Psychological dependence (i.e., addiction) is not associated with physical
discomfort after discontinuation. It refers to intense craving and compulsive
use.
nonREM sleep
Give this one a try later!
i. stage 1- onset of sleep 1-7m
ii. stage 2 - deeper 10-25m
iii. stage 3 - deep sleep few minutes
iv. stage 4 - deep sleep 20-40m
Which type of pharmacotherapeutic agent uses an herbal product to produce a
desired clinical effect?
Give this one a try later!
natural health product
Are there tertiary prevention programs? Examples?
Give this one a try later!
