BASIC AND CLINICAL
PHARMACOLOGY 15TH EDITION
TEST BANK 2026 COMPLETE EXAM
QUESTIONS SOLUTIONS GRADED A+
◉ 2. Drugs that have a significant first-pass effect:
1. Must be given by the enteral (oral) route only
2. Bypass the hepatic circulation
3. Are rapidly metabolized by the liver and may have little if any desired
action
4. Are converted by the liver to more active and fat-soluble forms
Answer: 3. Are rapidly metabolized by the liver and may have little if
any desired action
◉ 3. The route of excretion of a volatile drug will likely be the:
1. Kidneys
2. Lungs
3. Bile and feces
4. Skin
Answer: 2. Lungs
◉ 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly
(IM) to create a storage reservoir of the drug. Storage reservoirs:
1. Assure that the drug will reach its intended target tissue
, 2. Are the reason for giving loading doses
3. Increase the length of time a drug is available and active
4. Are most common in collagen tissues
Answer: 3. Increase the length of time a drug is available and active
◉ 5. The NP chooses to give cephalexin every 8 hours based on
knowledge of the drug's:
1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects
Answer: 2. Biological half-life
◉ 6. Azithromycin dosing requires that the first day's dosage be twice
those of the other 4 days of the prescription. This is considered a loading
dose. A loading dose:
1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function
4. Is directly related to the drug circulating to the target tissues
Answer: 1. Rapidly achieves drug levels in the therapeutic range
◉ The point in time on the drug concentration curve that indicates the
first sign of a therapeutic effect is the:
PHARMACOLOGY 15TH EDITION
TEST BANK 2026 COMPLETE EXAM
QUESTIONS SOLUTIONS GRADED A+
◉ 2. Drugs that have a significant first-pass effect:
1. Must be given by the enteral (oral) route only
2. Bypass the hepatic circulation
3. Are rapidly metabolized by the liver and may have little if any desired
action
4. Are converted by the liver to more active and fat-soluble forms
Answer: 3. Are rapidly metabolized by the liver and may have little if
any desired action
◉ 3. The route of excretion of a volatile drug will likely be the:
1. Kidneys
2. Lungs
3. Bile and feces
4. Skin
Answer: 2. Lungs
◉ 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly
(IM) to create a storage reservoir of the drug. Storage reservoirs:
1. Assure that the drug will reach its intended target tissue
, 2. Are the reason for giving loading doses
3. Increase the length of time a drug is available and active
4. Are most common in collagen tissues
Answer: 3. Increase the length of time a drug is available and active
◉ 5. The NP chooses to give cephalexin every 8 hours based on
knowledge of the drug's:
1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects
Answer: 2. Biological half-life
◉ 6. Azithromycin dosing requires that the first day's dosage be twice
those of the other 4 days of the prescription. This is considered a loading
dose. A loading dose:
1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function
4. Is directly related to the drug circulating to the target tissues
Answer: 1. Rapidly achieves drug levels in the therapeutic range
◉ The point in time on the drug concentration curve that indicates the
first sign of a therapeutic effect is the:
