3310 SAR (Exam 2) questions with
correct answers 2026
CA SAR 1 - CORRECT ANSWER -sulfonamide must be primary
CA SAR 2 - CORRECT ANSWER -group attached to sulfonamide must be aromatic
CA SAR 3 - CORRECT ANSWER -lower aka increases CA inhibitory activity
CA SAR 4 - CORRECT ANSWER -increased lipid character increases CA inhibitory activity
CA SAR 5 - CORRECT ANSWER -NH2 increases saluretic effect and decreases CA inhibitory effect
thiazides SAR 1 - CORRECT ANSWER -N-2 position must be small (CH3 or H)
thiazides SAR 2 - CORRECT ANSWER -3-
position R group determines potency and duration of action; increased lipophilicity increases p
otency and duration
thiazides SAR 3 - CORRECT ANSWER -3-4 double bond reduction increases potency
thiazides SAR 4 - CORRECT ANSWER -alkyl groups at 4, 5, or 8 decrease diuretic effect
thiazides SAR 5 - CORRECT ANSWER -6-position EWG affects sulfonamide at position-
7; lower pKa= more ionized thus less reabsorbed
thiazides SAR 6 - CORRECT ANSWER -sulfonamide at 7-position must be unsubstituted
correct answers 2026
CA SAR 1 - CORRECT ANSWER -sulfonamide must be primary
CA SAR 2 - CORRECT ANSWER -group attached to sulfonamide must be aromatic
CA SAR 3 - CORRECT ANSWER -lower aka increases CA inhibitory activity
CA SAR 4 - CORRECT ANSWER -increased lipid character increases CA inhibitory activity
CA SAR 5 - CORRECT ANSWER -NH2 increases saluretic effect and decreases CA inhibitory effect
thiazides SAR 1 - CORRECT ANSWER -N-2 position must be small (CH3 or H)
thiazides SAR 2 - CORRECT ANSWER -3-
position R group determines potency and duration of action; increased lipophilicity increases p
otency and duration
thiazides SAR 3 - CORRECT ANSWER -3-4 double bond reduction increases potency
thiazides SAR 4 - CORRECT ANSWER -alkyl groups at 4, 5, or 8 decrease diuretic effect
thiazides SAR 5 - CORRECT ANSWER -6-position EWG affects sulfonamide at position-
7; lower pKa= more ionized thus less reabsorbed
thiazides SAR 6 - CORRECT ANSWER -sulfonamide at 7-position must be unsubstituted
