Week 11 Final Exam Review – Comprehensive Practice Questions and Answer Guide

FINAL EXAM WEEK 11

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 Question 1
FILL IN THE BLANK: ___________ is the main neurotransmitter behind reward systems in
the brain, which usually leads to addiction when altered in any way. DOPAMINE


Response “Distribution of the endogenous reward systems in the brain is a
Feedback: common feature of drug abuse; most addictive drugs act by
disrupting central nervous system (CNS) dopamine circuits.”
- Table 16-1 as well all the drug types show alterations of dopamine
pathways in some way

 Question 2
L. J. is a 55-year-old male who attended a funeral and found himself laughing during the
service, but later that evening he was irritated with himself for what he had done. His
wife said this was abnormal behavior and took him to his doctor to be evaluated. After L.
J.’s MRI was reviewed, he was diagnosed with frontotemporal dementia. Which
medication is recommended to help L. J. with his emotional outbursts? ESCITALOPRAM


Response under Treatment subtitle: “The behavioral features are sometimes
Feedback: helped by SSRIs, and these are the best-studied treatments for these
disorders.”

 Question 3
In the pathophysiology of Alzheimer’s Disease, there are certain proteins that lead to
the plaques and tangles that result in this progressive, irreversible brain disorder.
Choose the appropriate protein with its corresponding pathology. I and IV

I. Tau – tangles
II. Beta-amyloid – tangles
III. Tau – plaques
IV. Beta-amyloid – plaques


 Question 4
Patient is a 75-year-old female with a confirmed diagnosis of Alzheimer’s Disease. She is
currently on Donepezil 10 mg daily. She is accompanied to your clinic today by her
daughter, who informs you that her mother has recently had an increase in depressive
symptoms. She has no history of mood disorders. She has a history of hypertension and
tonic-clonic seizures, but both are controlled. Assuming this patient will be thoroughly
evaluated for the diagnosis of depression, what would you recommend as initial
therapy? FLUOXETINE

, Response SSRIs are effective in treating depressive symptoms. Answer choices A
Feedback: & B are both TCAs and are advised against due to side effect profile
and the fact this person is treatment naive (learned from previous
exam) and answer choice D is contraindicated in a patient with
seizures.

 Question 5
The experience of pain is ALWAYS subjective YES IT IS ALWAYS SUBJECTIVE


Response “The experience of pain is always
Feedback: subjective.”

 Question 6
Of the following neurotransmitters, which ones play a critical role in modulating
attention in ADHD? C . I and IV

I. Dopamine
II. Epinephrine
III. GABA
IV. Norepinephrine
V. Glutamate

Response "Stimulants increase intra-synaptic concentrations of dopamine
Feedback: (DA) and norepinephrine (NE)”

 Question 7
There are many different types of dementia. Which dementia is NOT a direct result of
disrupted neurotransmitters, but a result of degeneration of different regions in the
brain? Onset of the disease is typically before the age of 60, and very rare after the age
of 75.

Alzheimer Disease


Response under subtitle “Epidemiology and genetic
Feedback: risk factors”

 Question 8
This medication cannot be used for more than 5 days, it is a non-steroidal, anti-
inflammatory drug, and it is often substituted for morphine due to its rapid onset and
high potency. What is this medication? KETOROLAC, DUH


Response under non-steroidal, anti-
Feedback: inflammatory drugs


 Question 9
Benzodiazepines can be withdrawn abruptly despite duration of therapy/abuse. FALSE