NBEO - Part 1 General Pharmacology: Questions
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Terms in this set (361)
'Buy AT 30, Cel at 50" antibiotics the inhibit the 30s subunit: AT
Aminoglycosides and tetracyclines
and 50s subunit: CEL
Chloraphenicol, Erythromycin (macrolide),
Lincomycin(/Clindamycin)
which 3 mechanisms do antimicrobials 1. inhibition of cell wall synthesis
target the bacteria: 2. inhibition of protein synthesis
3. interfering with bacterial DNA
true or false: bacterial ribosomes are false, they are made of 70S - although they are made
made of 80S up of 30S and 50S subunits
which antimicrobial medications inhibit bacitracin
cell wall synthesis? penicillins and cephalosporins
bacteria produce their own folic acid
drugs that inhibit folic acid synthesis (1) Sulfonamides
(2) Trimethoprim and Pyrimethamine
drugs that inhibit DNA gyrase and fluoroquinolones
topoisomerase IV
bacitracin prevents the transfer of peptidoglycan into the growing cell
wall
,penicillin and cephalosporins inhibit inhibiting transpeptidase
cell wall synthesis by
bacitracin is effective against gram (+) only, ointment used for blepharitis
Polysporin polymyxin B (gram -) and bacitracin (gram +)
Neosporin polysporin (polymyxin B (gram -) and bacitracin
(gram +) + neomycin
both amoxicillin and dicloxacillin have (+), (-)
gram __ coverage, but amoxicillin has amoxicillin = broad spectrum
better gram ___ coverage
pencillins Amoxicillin and dicloxacillin
Unlike dicloxacillin, amoxicillin is NOT resistant to penicillinase
oxacillin and cloxacillin are also penicillinase
resistant
Augmentin Amoxicillin + Clavulanate (penicillinase inhibitor)
4 medicating that can cause "CATS" - remember that typically effects women that
Pseudotumor cerebri: are overweight and are over childbearing age (fat,
fertile, female)... probably have a lot of cats
Contraceptives (oral)
Accutane
Tetracyclines
Synthroid (hypothyroid med)
,Drugs you never want to prescribe to "she's not FATS she is PACing a baby" - dont call a
a pregnant woman: pregnant lady fat = dont give FAT drugs; PAC drugs
are safe
Fluoroquinolone's
Aminoglycosides
Tetracyclines
Sulfonamides
Penicillins
Azithromycin - safest
Cepholoporins
doxycycline can be taken ___ food with
it is digested through fecal route so pts with renal
failure are safe to use it
azithromycin must be taken ___ food without
"a = without"
drugs you must take with an empty "PAT your empty belly"
stomach: Penicillin
Azithromycin**
Tetracyclines (exception doxy - take with food!)**
minocycline may cause blue sclera and pigmented cyst on the conjunctiva
"mino (cyst) is swimming through the blue ocean
(sclera)"
common adverse effects of penicillins hypersensitivity reactions: urticaria and anaphylaxis
are (Type 1) and contact dermatitis (type 4)
render oral contraceptives inactive
SJS in amoxicillin has been reported
true or false: penicillin is very safe in true
all trimesters of pregnancy (one of the PAC drugs;
Penicillins
Azithromycin - safest
Cepholoporins)
, cephalosporins and penicillins both beta-lactam ring
contain penicillin = 5 ring
cephalosporins = 6 ring
if a pt is allergic to penicillin there is 1%
an approx. ___% risk the pt will also be
allergic to1st generation
cephalosporins
cephalosporins and penicillins are have had IgE - Type 1 hypersensitivity rxns like
contraindicated in patients who anaphylaxis or urticaria
urticaria allergic reaction of the skin characterized by the
eruption of pale red, elevated patches called wheals
or hives - Type 1 Hypersensitivity rxn
1st generation cephalosporins gram +
ex: Cephalexin (Keflex) - Tx: skin infections including
dacryoadenitis, dacryocystitis, and preseptal cellulitis
2nd generation cephalosporins gram + and some gram -
3rd and 4th generation gram + and gram - (broad spectrum)
cephalosporins ex: ceftriaxone (Rocephin) - Tx: gonococcal conj.
dicloxacillin is the drug of choice for "Methicillin-SENSITIVE" staphylococcal infections,
especially methicillin-sensitive staph aureus (MSSA)
NOT MRSA*** - "Methicillin-RESISTANT"
Tx of choice for gonococcal IV ceftriaxone
conjunctivitis and orbital cellulitis
IM ceftriaxone for gonorrhea (no conj)
cephalosporins can alter the normal vitamin K --> leads to excessive thinning of the blood
intestinal flora, which alters the in pt taking warfarin (vitamin K antagonist)
absorption of ___
**hypersensitivity reactions is another adverse effect
With Expert Solutions
Save Groups
Terms in this set (361)
'Buy AT 30, Cel at 50" antibiotics the inhibit the 30s subunit: AT
Aminoglycosides and tetracyclines
and 50s subunit: CEL
Chloraphenicol, Erythromycin (macrolide),
Lincomycin(/Clindamycin)
which 3 mechanisms do antimicrobials 1. inhibition of cell wall synthesis
target the bacteria: 2. inhibition of protein synthesis
3. interfering with bacterial DNA
true or false: bacterial ribosomes are false, they are made of 70S - although they are made
made of 80S up of 30S and 50S subunits
which antimicrobial medications inhibit bacitracin
cell wall synthesis? penicillins and cephalosporins
bacteria produce their own folic acid
drugs that inhibit folic acid synthesis (1) Sulfonamides
(2) Trimethoprim and Pyrimethamine
drugs that inhibit DNA gyrase and fluoroquinolones
topoisomerase IV
bacitracin prevents the transfer of peptidoglycan into the growing cell
wall
,penicillin and cephalosporins inhibit inhibiting transpeptidase
cell wall synthesis by
bacitracin is effective against gram (+) only, ointment used for blepharitis
Polysporin polymyxin B (gram -) and bacitracin (gram +)
Neosporin polysporin (polymyxin B (gram -) and bacitracin
(gram +) + neomycin
both amoxicillin and dicloxacillin have (+), (-)
gram __ coverage, but amoxicillin has amoxicillin = broad spectrum
better gram ___ coverage
pencillins Amoxicillin and dicloxacillin
Unlike dicloxacillin, amoxicillin is NOT resistant to penicillinase
oxacillin and cloxacillin are also penicillinase
resistant
Augmentin Amoxicillin + Clavulanate (penicillinase inhibitor)
4 medicating that can cause "CATS" - remember that typically effects women that
Pseudotumor cerebri: are overweight and are over childbearing age (fat,
fertile, female)... probably have a lot of cats
Contraceptives (oral)
Accutane
Tetracyclines
Synthroid (hypothyroid med)
,Drugs you never want to prescribe to "she's not FATS she is PACing a baby" - dont call a
a pregnant woman: pregnant lady fat = dont give FAT drugs; PAC drugs
are safe
Fluoroquinolone's
Aminoglycosides
Tetracyclines
Sulfonamides
Penicillins
Azithromycin - safest
Cepholoporins
doxycycline can be taken ___ food with
it is digested through fecal route so pts with renal
failure are safe to use it
azithromycin must be taken ___ food without
"a = without"
drugs you must take with an empty "PAT your empty belly"
stomach: Penicillin
Azithromycin**
Tetracyclines (exception doxy - take with food!)**
minocycline may cause blue sclera and pigmented cyst on the conjunctiva
"mino (cyst) is swimming through the blue ocean
(sclera)"
common adverse effects of penicillins hypersensitivity reactions: urticaria and anaphylaxis
are (Type 1) and contact dermatitis (type 4)
render oral contraceptives inactive
SJS in amoxicillin has been reported
true or false: penicillin is very safe in true
all trimesters of pregnancy (one of the PAC drugs;
Penicillins
Azithromycin - safest
Cepholoporins)
, cephalosporins and penicillins both beta-lactam ring
contain penicillin = 5 ring
cephalosporins = 6 ring
if a pt is allergic to penicillin there is 1%
an approx. ___% risk the pt will also be
allergic to1st generation
cephalosporins
cephalosporins and penicillins are have had IgE - Type 1 hypersensitivity rxns like
contraindicated in patients who anaphylaxis or urticaria
urticaria allergic reaction of the skin characterized by the
eruption of pale red, elevated patches called wheals
or hives - Type 1 Hypersensitivity rxn
1st generation cephalosporins gram +
ex: Cephalexin (Keflex) - Tx: skin infections including
dacryoadenitis, dacryocystitis, and preseptal cellulitis
2nd generation cephalosporins gram + and some gram -
3rd and 4th generation gram + and gram - (broad spectrum)
cephalosporins ex: ceftriaxone (Rocephin) - Tx: gonococcal conj.
dicloxacillin is the drug of choice for "Methicillin-SENSITIVE" staphylococcal infections,
especially methicillin-sensitive staph aureus (MSSA)
NOT MRSA*** - "Methicillin-RESISTANT"
Tx of choice for gonococcal IV ceftriaxone
conjunctivitis and orbital cellulitis
IM ceftriaxone for gonorrhea (no conj)
cephalosporins can alter the normal vitamin K --> leads to excessive thinning of the blood
intestinal flora, which alters the in pt taking warfarin (vitamin K antagonist)
absorption of ___
**hypersensitivity reactions is another adverse effect
