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LEHNINGER PRINCIPLES OF BIOCHEMISTRY 2026 MOCK PAPER COMPREHENSIVE REVIEW NOTES ANALYTICAL SUMMARY

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LEHNINGER PRINCIPLES OF BIOCHEMISTRY 2026 MOCK PAPER COMPREHENSIVE REVIEW NOTES ANALYTICAL SUMMARY

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LEHNINGER PRINCIPLES OF BIOCHEMISTRY
2026 MOCK PAPER COMPREHENSIVE REVIEW
NOTES ANALYTICAL SUMMARY

◉ Human genomic DNA.
Answer: Less than 1.5% encodes proteins, with less than one-third
consisting of genes


◉ Transposons.
Answer: Nucleic acid parasites accounting for about half of the
human genome


◉ Centromeres.
Answer: Special-function repetitive DNA sequences serving as
attachment points for the mitotic spindle


◉ Telomeres.
Answer: Repetitive DNA sequences located at the ends of
chromosomes


◉ Supercoiled DNA.

, Answer: Underwound state of DNA that is either a closed circle or
bound to protein


◉ Linking number (Lk).
Answer: Topological parameter quantifying underwinding of DNA


◉ Superhelical density (σ).
Answer: Measure of underwinding, typically -0.05 to -0.07 for
cellular DNAs


◉ Topoisomers.
Answer: DNAs that differ only in linking number


◉ Topoisomerases.
Answer: Enzymes that underwind and/or relax DNA, changing
linking number


◉ Type I topoisomerases.
Answer: Enzymes that change linking number in increments of 1 per
catalytic event


◉ Type II topoisomerases.

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