lOMoAR cPSD| 47246286
Study guide exam one units 1-3
Principles Of Pharmacology (Galen College of
Nursing)
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, lOMoAR cPSD| 47246286
Study guide exam one units 1-3
Unit one Week one pharmacology
Pharmacokinetics and Pharmacodynamics
Week one notes
Pharmacodynamics- what the drug does to the body
What effect does the drug have on the person you are giving it to
Pharmacokinetics- Pharmaco (drug) kinetics (movement)
- What does the body do to the drug
Pharmacokinetics has 4 phase
AD-ME – Absorption, distribution, metabolism, excretion
A-Absorption
Drug moves from site of absorption (small intestine) into the
bloodstream
Bioavailability – how much of the drug reaches the blood
stream
Factors affecting absorption
1.Circulation
- Poor blood flow to the GI tract and you taking oral med will lead
to a decrease in the rate of absorption
- Happens in pt. in shock or vasoconstricting drugs
2. Pain, stress, exercise
- Blood gets shunted away from the gut.
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, lOMoAR cPSD| 47246286
Food / decrease in GI motility
- delays absorption
PH
- most drugs needs a low PH for absorption acids breaks things
down into a more absorbable form
Route
- route of administration affects absorption /bioavailability
- iv = 100 percent bioavailability
80 % of drugs are taken orally
- in order for drug to be used (absorbed) has to go through a process
called disintegration – (broken down into smaller particles.) then it
has to dissolve (dissolution)
- enteric coated tabs slower disintegration
- enteric coated tabs need an alkaline environment for absorption
first pass effect
- affects absorption /bioavailability of oral medications
- example of the 1st pass effect is PO vs IV Tylenol
- drug travels to the liver via the portal vein and gets broken down
D- distribution
- Describes delivery of the blood from the blood stream to the tissue
(target cells)
Factors affecting distribution
Downloaded by Cripto ()
Study guide exam one units 1-3
Principles Of Pharmacology (Galen College of
Nursing)
Scan to open on Studocu
Studocu is not sponsored or endorsed by any college or university
Downloaded by Cripto ()
, lOMoAR cPSD| 47246286
Study guide exam one units 1-3
Unit one Week one pharmacology
Pharmacokinetics and Pharmacodynamics
Week one notes
Pharmacodynamics- what the drug does to the body
What effect does the drug have on the person you are giving it to
Pharmacokinetics- Pharmaco (drug) kinetics (movement)
- What does the body do to the drug
Pharmacokinetics has 4 phase
AD-ME – Absorption, distribution, metabolism, excretion
A-Absorption
Drug moves from site of absorption (small intestine) into the
bloodstream
Bioavailability – how much of the drug reaches the blood
stream
Factors affecting absorption
1.Circulation
- Poor blood flow to the GI tract and you taking oral med will lead
to a decrease in the rate of absorption
- Happens in pt. in shock or vasoconstricting drugs
2. Pain, stress, exercise
- Blood gets shunted away from the gut.
Downloaded by Cripto ()
, lOMoAR cPSD| 47246286
Food / decrease in GI motility
- delays absorption
PH
- most drugs needs a low PH for absorption acids breaks things
down into a more absorbable form
Route
- route of administration affects absorption /bioavailability
- iv = 100 percent bioavailability
80 % of drugs are taken orally
- in order for drug to be used (absorbed) has to go through a process
called disintegration – (broken down into smaller particles.) then it
has to dissolve (dissolution)
- enteric coated tabs slower disintegration
- enteric coated tabs need an alkaline environment for absorption
first pass effect
- affects absorption /bioavailability of oral medications
- example of the 1st pass effect is PO vs IV Tylenol
- drug travels to the liver via the portal vein and gets broken down
D- distribution
- Describes delivery of the blood from the blood stream to the tissue
(target cells)
Factors affecting distribution
Downloaded by Cripto ()
