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Pharmacology SSE Specialty Examination, 2026/2027 – 100-Question NGN-Style Pharmacology Competency Assessment with Verified Rationales

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Pharmacology SSE Specialty Examination, 2026/2027 – 100-Question NGN-Style Pharmacology Competency Assessment with Verified Rationales

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What is the indication for metoclopramide/reglan? - ANSWER-Prevention of
chemotherapy-induced emesis and diabetic gastroparesis
Side effects of metoclopramide/reglan - ANSWER-Drowsiness, EPS such as tremors
Notify MD if what occurs when using metoclopramide/reglan - ANSWER-Tremors
What is the indication xenical (orlistat, Alli) - ANSWER-For PTs with BMI of 30+; LT
weight control
SE of xenical (orlistat or alli) - ANSWER-Oily stool and flatulence
Nursing implications for a pt on xenical (orlistat or alli) - ANSWER-Ask pt to describe
dietary intake since SE are increased if greater than 30% of fat is in diet.
What can decrease side effects of xenical (orlistat or alli) - ANSWER-Fiber laxatives like
Metamucil help decrease SE by binding to the fat.
Which type of fluids need plenty of water? - ANSWER-Bulk forming laxatives
Why do you need plenty of fluids when taking bulk forming laxatives - ANSWER-
Because they can produce esophageal and or intestinal obstruction
Laxative use assessment - ANSWER-Last BM and characteristics, abdominal pain, fever
and obstruction. Assess dietary and fluid intake.
With laxative use the nurse should - ANSWER-Encourage fluids, fiber and exercise as
tolerated/indicated
Laxative use and result in - ANSWER-Lack of bowel tone which can lead to dependency
what is ondansetron (zofran) - ANSWER-antiemetic
What is ondansetron (zofran)used for? - ANSWER-Prevention of N/V associated with
chemotherapy and radiation therapy.
Who should you use caution with when giving ondansetron/zofran? - ANSWER-PTs with
liver failure
Drugs for ulcerative colitis and crohns - ANSWER-5 aminosalicylates; mesalamie,
sulfasalazine.
How do 5 aminosalicylates; (mesalamie, sulfasalazine) work? - ANSWER-They decrease
GI inflammation
Side effects of 5 aminosalicylates; (mesalamie, sulfasalazine) - ANSWER-Nausea, rash,
arthralgia, hematological disorders

, Which drug can cause colitis/c.diff - ANSWER-Linezolid/zyvox
What kind of infection is c.diff - ANSWER-Suprainfection
What is azithromycin/zithromax? - ANSWER-An antibiotic
What does azithromycin/zithromax treat? - ANSWER-STDs such as: gonorrhea and
chlamydia
How much azithromycin/zithromax is usually required? - ANSWER-One dose of 1g or 2g.
If a female pt has trichomonas (any STI) and is asymptomatic does the male need to be
tested? - ANSWER-Yes!
azithromycin/zithromax can cause what? - ANSWER-Hepatotoxicity- elevated liver
enzymes
What is nitrofurantoin/cipro used for? - ANSWER-An antibiotic for UTI
nitrofurantoin/cipro side effect - ANSWER-Hepatotoxicity, skin reactions, neuropathy
nitrofurantoin/cipro nursing considerations - ANSWER-Give with milk or meals check
LFTs. Watch for numbness or tingling of extremities this can be an irreversible
peripheral neuropathy
Drug of choice for treating c.diff? - ANSWER-Metronidazole/flagyl
When is metronidazole/flagyl to be taken? - ANSWER-With food and around the clock
What should be avoided when taking metronidazole/flagyl and why? - ANSWER-Alcohol;
can cause a disulfiram-like reaction
aminoglycosides examples - ANSWER-gentamicin(garamycin), neomycin,
tobramycin(nebcin)
how are aminoglycosides ,(-mycin, -micin), administered? - ANSWER-given IV for
several days
what is an adverse effect of aminoglycosides (-mycin, -micin) - ANSWER-decreased
hearing/ototoxicity and nephrotoxicity
what labs need to be evaluated when given aminoglycosides (-mycin, -micin)? -
ANSWER-BUN and creatinine
DOC for MRSA - ANSWER-vancomycin
what is MRSA - ANSWER-severe staph infections that have become resistant to most
antibiotics
implications for giving vancomycin - ANSWER-acute care requires frequent monitoring
og serum drug level for dose adjustment. peak and trough schedule. trough is drawn
just prior to next dose.
risks when using vancomycin - ANSWER-nephrotoxicity and ototoxicity
SE of vancomycin - ANSWER-thrombophlebitis, red man syndrome if infused too rapidly:
flushing or rash of upper body, dyspnea, itching, hypotension- can be lethal
how long should IV vancomycin infuse? - ANSWER-greater than 60 minutes
what is trimethoprim/sulfamethoxazole? - ANSWER-it is a sulfonamide for treatment of
UTI. combination increases efficacy and inhibits metabolism of folic acid at two different
points
what is trimethoprim/sulfamethoxazole known for? - ANSWER-sulfa allergy
nursing implications for trimethoprim/sulfamethoxazole - ANSWER-assess for rash due
to potential for stevens johnson syndrome
penicillins have a ____ to ____ - ANSWER-cross-sensitivity; cephalosporins. they are
structurally similar.

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