CMN 548 UNIT 5 ENTRANCE EXAMINATION WITH
RESEARCHED COMPLETE QUESTIONS AND 100%
CORRECT VERIFIED ANSWERS ALREADY GRADED
A+
Potency - CORRECT ANSWER>>>refers to the relative dose required to achieve certain
effects, not to the efficacy of a drug
Agonist (full agonist) - CORRECT ANSWER>>>A drug that binds to a specific receptor
producing an effect identical to that usually produced by the neurotransmitter affecting that
receptor
Pharmacodynamics - CORRECT ANSWER>>>The time course and intensity of a drug's
effect/what the drug does to the body
Pharmacokinetics - CORRECT ANSWER>>>What the body does to a drug
Tolerance - CORRECT ANSWER>>>Develops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased sensitivity to adverse effects of a
drug
Stevens-Johnson Syndrome - CORRECT ANSWER>>>A systemic, immune-mediated
reaction that can be fatal or result in permanent scarring or blindness
Antagonist - CORRECT ANSWER>>>A compound that blinds to a receptor that blocks or
reduces the action of another substance at the receptor site
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,Hyponatremia - CORRECT ANSWER>>>Common symptoms of this medication side effect
include confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index - CORRECT ANSWER>>>ratio of the median toxic dose to the median
effective dose
Somnolence - CORRECT ANSWER>>>Daytime sleepiness
Black Box Warning - CORRECT ANSWER>>>This warning reflects that a medication may
cause a serious or even life-threatening side effect
Partial or Mixed Agonist - CORRECT ANSWER>>>A compound that elicits a partial
pharmacological response at the receptor site involved
Remission - CORRECT ANSWER>>>The degree of improvement to below the syndromal
threshold of a disorder
Paradoxical - CORRECT ANSWER>>>A response to a drug that represents the clinical
effect opposite of what is expected
Inverse agonist - CORRECT ANSWER>>>An agent that binds to the same receptor site as
an agonist but produces the opposite pharmacological effect
4 major transmitters - CORRECT ANSWER>>>Dopamine, Serotonin, GABA,
Norepinephrine
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,Dopamine transmitter affects? - CORRECT ANSWER>>>affects mood, Psychosis, ADHD,
Addiction
Serotonin transmitter affects? - CORRECT ANSWER>>>Depression, aggression, OCD,
Panic, GAD, Social Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - CORRECT ANSWER>>>Affects mood, anxiety, psychosis, ADHD
(part), drug withdrawal
GABA affects? - CORRECT ANSWER>>>Fear, anxiety, worry
Irreversible MAOIs Types - CORRECT ANSWER>>>MAOa and MAOb
Irreversible MAOIs medications - CORRECT ANSWER>>>Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? - CORRECT
ANSWER>>>because they irreversibly inactivate MAOs, the therapeutic effect of a single dose
of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - CORRECT
ANSWER>>>orthostatic hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - CORRECT ANSWER>>>Moclobemide (Maerix)
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, How long will it take to recover MAO activity after a final dose of RIMA? - CORRECT
ANSWER>>>MAO activity recovers completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - CORRECT ANSWER>>>depression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - CORRECT ANSWER>>>Avoid
caffeine
intake of 2L of fluid/day
addition of dietary salt
adjust HTN meds
support stocking
severe cases *tx with fludrocortisone (Florinef) a mineralcorticoid
How long should the NP wait to begin another tx for depression when stopping an MAOI to
begin another MAOI or SSRI? - CORRECT ANSWER>>>irreversible MAOI-wait 14 days
MAO activity recovers completely 24-48 hrs after last dose of RIMA
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RESEARCHED COMPLETE QUESTIONS AND 100%
CORRECT VERIFIED ANSWERS ALREADY GRADED
A+
Potency - CORRECT ANSWER>>>refers to the relative dose required to achieve certain
effects, not to the efficacy of a drug
Agonist (full agonist) - CORRECT ANSWER>>>A drug that binds to a specific receptor
producing an effect identical to that usually produced by the neurotransmitter affecting that
receptor
Pharmacodynamics - CORRECT ANSWER>>>The time course and intensity of a drug's
effect/what the drug does to the body
Pharmacokinetics - CORRECT ANSWER>>>What the body does to a drug
Tolerance - CORRECT ANSWER>>>Develops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased sensitivity to adverse effects of a
drug
Stevens-Johnson Syndrome - CORRECT ANSWER>>>A systemic, immune-mediated
reaction that can be fatal or result in permanent scarring or blindness
Antagonist - CORRECT ANSWER>>>A compound that blinds to a receptor that blocks or
reduces the action of another substance at the receptor site
1|Page
,Hyponatremia - CORRECT ANSWER>>>Common symptoms of this medication side effect
include confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index - CORRECT ANSWER>>>ratio of the median toxic dose to the median
effective dose
Somnolence - CORRECT ANSWER>>>Daytime sleepiness
Black Box Warning - CORRECT ANSWER>>>This warning reflects that a medication may
cause a serious or even life-threatening side effect
Partial or Mixed Agonist - CORRECT ANSWER>>>A compound that elicits a partial
pharmacological response at the receptor site involved
Remission - CORRECT ANSWER>>>The degree of improvement to below the syndromal
threshold of a disorder
Paradoxical - CORRECT ANSWER>>>A response to a drug that represents the clinical
effect opposite of what is expected
Inverse agonist - CORRECT ANSWER>>>An agent that binds to the same receptor site as
an agonist but produces the opposite pharmacological effect
4 major transmitters - CORRECT ANSWER>>>Dopamine, Serotonin, GABA,
Norepinephrine
2|Page
,Dopamine transmitter affects? - CORRECT ANSWER>>>affects mood, Psychosis, ADHD,
Addiction
Serotonin transmitter affects? - CORRECT ANSWER>>>Depression, aggression, OCD,
Panic, GAD, Social Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - CORRECT ANSWER>>>Affects mood, anxiety, psychosis, ADHD
(part), drug withdrawal
GABA affects? - CORRECT ANSWER>>>Fear, anxiety, worry
Irreversible MAOIs Types - CORRECT ANSWER>>>MAOa and MAOb
Irreversible MAOIs medications - CORRECT ANSWER>>>Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? - CORRECT
ANSWER>>>because they irreversibly inactivate MAOs, the therapeutic effect of a single dose
of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - CORRECT
ANSWER>>>orthostatic hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - CORRECT ANSWER>>>Moclobemide (Maerix)
3|Page
, How long will it take to recover MAO activity after a final dose of RIMA? - CORRECT
ANSWER>>>MAO activity recovers completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - CORRECT ANSWER>>>depression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - CORRECT ANSWER>>>Avoid
caffeine
intake of 2L of fluid/day
addition of dietary salt
adjust HTN meds
support stocking
severe cases *tx with fludrocortisone (Florinef) a mineralcorticoid
How long should the NP wait to begin another tx for depression when stopping an MAOI to
begin another MAOI or SSRI? - CORRECT ANSWER>>>irreversible MAOI-wait 14 days
MAO activity recovers completely 24-48 hrs after last dose of RIMA
4|Page
