HESI PHARMACOLOGY EXAM PRACTICE 2026/2027 (NCLEX PN) ACTUAL EXAM COMPLETE QUESTIONS WITH DETAILED VERIFIED ANSWERS AND RATIONALES (100% CORRECT ANSWERS) /ALREADY GRADED A+

HESI PHARMACOLOGY EXAM PRACTICE 2026/2027 (NCLEX PN) ACTUAL EXAM COMPLETE QUESTIONS WITH DETAILED VERIFIED ANSWERS AND RATIONALES (100% CORRECT ANSWERS) /ALREADY GRADED A+ The nurse is assessing a stuporous client in the emergency department who is suspected of overdosing on opioids. Which agent should the nurse prepare to administer if the client becomes comatose? A. Naloxone hydrochloride B. Atropine sulfate C. Vitamin K D. Flumazenil - ANSWER️A. Naloxone hydrochloride Naloxone is an opioid antidote used in opioid overdose to reverse CNS and respiratory depression. Atropine is used for bradycardia, intestinal hypertonicity and hypermotility, muscarinic agonist poisoning, peptic ulcer disease, and biliary colic. Vitamin K is used to manage warfarin overdose and vitamin K deficiency in newborns. Flumazenil reduces the sedative effects of benzodiazepines following general anesthesia or overdose. To evaluate whether the administration of an antihypertensive medication has caused a therapeutic effect, which action should the nurse implement? A. Ask the client about the onset of any dizziness since taking the medication. B. Measure the client's blood pressure while the client is lying, sitting, and then standing. C. Compare the client's blood pressure before and after the client takes the medication. D. Interview the client about any past or recent history of high blood pressure. - ANSWER️C. Compare the client's blood pressure before and after the client takes the medication. Therapeutic effects are the expected or predictable physiologic responses to a medication. An antihypertensive medication is administered to lower blood pressure, so to determine if the therapeutic effect has been achieved, the nurse should compare the client's blood pressure before and after the client takes the medication. Options A and B provide data related to the side effect of hypotension, which may occur following the administration of an antihypertensive medication. Option D provides useful data but does not evaluate the medication's effectiveness. During the initial nursing assessment, a client tells the nurse that he is taking tetracycline hydrochloride for urethritis. The nurse is most concerned about which medication the client reports taking concurrently. A. Sucralfate B. Hydrochlorothiazide C. Acetaminophen D. Phenytoin - ANSWER️A. Sucralfate Sucralfate is used to treat duodenal ulcers and will bind with tetracycline hydrochloride, inhibiting this antibiotic's absorption. Options B, C, and D have no drug interaction properties that prohibit concurrent use with tetracycline hydrochloride. The health care provider prescribes oral contraceptives for a client who wants to prevent pregnancy. Which information is the most important for the nurse to provide to this client? A. Take one pill at the same time every day until all the pills are gone. B. Use condoms and foam instead of the pill while on any antibiotics. C. Limit sexual intercourse for at least one cycle after starting the pill. D. Use another contraceptive if two or more pills are missed in one cycle. - ANSWER️A. Take one pill at the same time every day until all the pills are gone. To maintain adequate hormonal levels for contraception and enhance compliance, oral contraceptives should be taken at the same time each day. There is no strong pharmacokinetic evidence that shows a relationship between the category of broad-spectrum antibiotic use and altered hormone levels in oral contraceptive users, so option B is not indicated at this time. Abstinence is the best method to prevent pregnancy during the first cycle. If a client misses two pills during the first week, the client should take two pills a day for 2 days and finish the package while using a backup method of birth control until her next menstrual cycle. Prior to administering a scheduled dose of digoxin, the nurse reviews the client's current serum digoxin level, which is 1.3 ng/dL. Which action should the nurse implement? A. Administer Digibind to counteract the toxicity. B. Withhold the drug and notify the health care provider immediately. C. Withhold the dose and notify the health care provider during rounds that the dose was held. D. Give the dose of digoxin if the client's heart rate is within a safe range. - ANSWER️D. Give the dose of digoxin if the client's heart rate is within a safe range. The client's digoxin level of 1.3 ng/dL is not above the upper range of its therapeutic index (toxic level is 2.0 ng/dL), so the dose should be administered after the client's heart rate is evaluated. Digibind is administered for toxic levels of digoxin, so option A is not indicated. Options B and C are not necessary. A 2-month-old infant is scheduled to receive the first DPT immunization. What is the preferred injection site to administer this immunization? A. Dorsal gluteal B. Vastus lateralis C. Ventral gluteal D. Deltoid - ANSWER️B. Vastus lateralis The preferred intramuscular site for children younger than 2 years is the vastus lateralis. Options A, C, and D are not preferred injection sites for the infant at 2 months of age. Which factor is most important to ensure compliance when planning to teach a client about a drug regimen? A. Genetics B. Client age C. Client education D. Absorption rate - ANSWER️C. Client education The client's educational level is the most important factor when planning teaching to ensure a client's compliance with taking a prescribed drug. Options A and D are physiologic responses that do not relate to a client's compliance. Although maturity level and age contribute to compliance, the client's basic understanding of instructions, which is best indicated by educational level, is more significant. A client is receiving acyclovir sodium IV for a severe herpes simplex infection. Which intervention should the nurse implement during this drug therapy? A. Maintain respiratory isolation precautions. B. Increase daily fluids to 2000 to 4000 mL/day. C. Administer with meals to decrease gastric irritation. D. Assess for signs of severe liver dysfunction. - ANSWER️B. Increase daily fluids to 2000 to 4000 mL/day. Increasing fluid intake during treatment prevents precipitation of the drug in the renal tubules, which could lead to obstructive problems that impair kidney function. Acute glomerulonephritis is a possible complication of acyclovir sodium therapy. Options A, C, and D are unrelated interventions for treatment with acyclovir sodium.