MICB 4131 EXAM 3 QUESTIONS AND VERIFIED
ANSWERS
C - Answers - Which of the following is not found in mucus?
A. Salts
B. Mucins
C. Lamina Propria
D. Antimicrobial Proteins
E. Antibodies
B - Answers - Which of the following is not a mucosal tissue?
A. Lungs
B. Skin
C. Urogenital tract
D. Small intestine
E - Answers - As you move distally through the gut (from the stomach to the large
intestine), the pH ___ and the amount of bacteria/microbiome ___
A. Decreases, decreases
B. Increases, decreases
C. Stays the same, increases
D. Decreases, stays the same
E. Increases, increases
B - Answers - Goblet cells:
A. Make antimicrobial proteins
B. Produce mucins
C. Perform phagocytosis
D. Produce tight junction proteins
E. Activate T cells within Peyer's patches
E - Answers - The majority of plasma cells in the small intestine produce this Ab isotype:
A. IgG
B. IgM
C. IgD
D. IgE
E. IgA
, C - Answers - This protein facilitates the transcytosis of mucosal antibody from the
intestinal lamina propria to the gut lumen:
A. Muc2
B. Lysozyme
C. Polymeric-Ig-Receptor (pIgR)
D. IL-4
E. A-Defensin
True - Answers - True or false: CD8 T cells in the intestine can be resident and are
cytotoxic.
B - Answers - Which has the largest surface area?
A. Skin
B. Intestines
C. Kidney
D. Spleen
E. Lungs
True - Answers - True or false: antibodies that bind to the receptor-binding domain
(RBD) of the SARS-CoV-2 spike protein are likely the most important immune
component for providing sterilizing/neutralizing immunity against SARS-CoV-2
False - Answers - True or false: RNA-based vaccines are different because they do not
induce affinity maturation in B cells.
B - Answers - Vaccination with FDA approved SARS-CoV-2 vaccines can:
A. give you SARS-CoV-2 in rare cases.
B. reduce the amount of virus you produce, if you are naturally infected.
C. protect you from flu infection.
False - Answers - True or false: memory B cells induced by SARS-CoV-2 infection fail
to undergo affinity maturation.
True - Answers - True or false: Natural infection with SARS-CoV-2 induces both B and
T cell responses.
E - Answers - Cancer can be induced by:
A. Smoking
B. Germline mutations
C. Viruses
D. Ionizing radiation
E. All of the above
ANSWERS
C - Answers - Which of the following is not found in mucus?
A. Salts
B. Mucins
C. Lamina Propria
D. Antimicrobial Proteins
E. Antibodies
B - Answers - Which of the following is not a mucosal tissue?
A. Lungs
B. Skin
C. Urogenital tract
D. Small intestine
E - Answers - As you move distally through the gut (from the stomach to the large
intestine), the pH ___ and the amount of bacteria/microbiome ___
A. Decreases, decreases
B. Increases, decreases
C. Stays the same, increases
D. Decreases, stays the same
E. Increases, increases
B - Answers - Goblet cells:
A. Make antimicrobial proteins
B. Produce mucins
C. Perform phagocytosis
D. Produce tight junction proteins
E. Activate T cells within Peyer's patches
E - Answers - The majority of plasma cells in the small intestine produce this Ab isotype:
A. IgG
B. IgM
C. IgD
D. IgE
E. IgA
, C - Answers - This protein facilitates the transcytosis of mucosal antibody from the
intestinal lamina propria to the gut lumen:
A. Muc2
B. Lysozyme
C. Polymeric-Ig-Receptor (pIgR)
D. IL-4
E. A-Defensin
True - Answers - True or false: CD8 T cells in the intestine can be resident and are
cytotoxic.
B - Answers - Which has the largest surface area?
A. Skin
B. Intestines
C. Kidney
D. Spleen
E. Lungs
True - Answers - True or false: antibodies that bind to the receptor-binding domain
(RBD) of the SARS-CoV-2 spike protein are likely the most important immune
component for providing sterilizing/neutralizing immunity against SARS-CoV-2
False - Answers - True or false: RNA-based vaccines are different because they do not
induce affinity maturation in B cells.
B - Answers - Vaccination with FDA approved SARS-CoV-2 vaccines can:
A. give you SARS-CoV-2 in rare cases.
B. reduce the amount of virus you produce, if you are naturally infected.
C. protect you from flu infection.
False - Answers - True or false: memory B cells induced by SARS-CoV-2 infection fail
to undergo affinity maturation.
True - Answers - True or false: Natural infection with SARS-CoV-2 induces both B and
T cell responses.
E - Answers - Cancer can be induced by:
A. Smoking
B. Germline mutations
C. Viruses
D. Ionizing radiation
E. All of the above
