ACRP CCRC CERTIFICATION
COMPREHENSIVE STUDY GUIDE 2026
FULL QUESTIONS AND SOLUTIONS
GRADED A+
◍ ACRP Certified Clinical Research Coordinator (CCRC) exam.
Answer: EXAM COVERAGECLINICAL RESEARCH COORDINATION
ROLES AND RESPONSIBILITIESCLINICAL TRIAL DESIGN,
PHASES, AND STUDY TYPESETHICAL AND REGULATORY
REQUIREMENTS (IRB, FDA, ICH-GCP)INFORMED CONSENT
PROCESS AND PARTICIPANT RIGHTSSTUDY PROTOCOL
IMPLEMENTATION AND ADHERENCESUBJECT RECRUITMENT,
SCREENING, AND ENROLLMENT PROCEDURESDATA
COLLECTION, MANAGEMENT, AND QUALITY
ASSURANCESAFETY REPORTING, ADVERSE EVENT
DOCUMENTATION, AND MONITORINGINTERACTIONS WITH
SPONSORS, INVESTIGATORS, AND RESEARCH
STAFFPROFESSIONALISM, ETHICS, AND CONTINUOUS
EDUCATION IN CLINICAL RESEARCH
◍ A subject is issued 120 tablets and is instructed to take 2 tablets 4 times a
day. He returns 88 tablets on the morning of day 9 fasting for laboratory
tests. What percent compliant is he?.
Answer: 50%
◍ Twenty-six subjects were enrolled in a pneumonia trial. The site received
100 bottles of I
P. Each subject received two bottles. Four subjects did not return their trial
bottles. How many bottles are available for the CRC to return to the sponsor
, at the end of the trial?.
Answer: 92
◍ A subject is participating in a clinical trial where only the pharmacist and
the sponsor know the identity of the I
P. The pharmacist has no direct contact with the trial subject and the clinical
team. Which of the following BEST describes this trial type?.
Answer: double-blind
◍ double-blind trial.
Answer: study where participants and the study team interacting with them
(investigator, arc) are unaware of treatment allocation
◍ A clinical trial is being conducted to determine the safety and tolerability of
a new anti-emetic I
P. The sponsor expects to enroll 20 subjects. This would be considered a.
Answer: Phase 1 Trial
◍ Phase 1 Trials primary objective.
Answer: non-therapeutic objectives, intended to determine tolerability of
dose ranges for future trials, and determine the nature of adverse events that
may be expected
◍ Phase 1 trials typically have a ________ group of subjects enrolled..
Answer: small
◍ Open-label trial.
Answer: both the researchers and subjects know which treatment is being
administered
◍ Single-blind trial.
Answer: subjects are not aware of which treatment is administered,
researchers do know
◍ therapeutic efficacy.
Answer: ability of a treatment (drug, therapy) to produce its intended
beneficial effects
COMPREHENSIVE STUDY GUIDE 2026
FULL QUESTIONS AND SOLUTIONS
GRADED A+
◍ ACRP Certified Clinical Research Coordinator (CCRC) exam.
Answer: EXAM COVERAGECLINICAL RESEARCH COORDINATION
ROLES AND RESPONSIBILITIESCLINICAL TRIAL DESIGN,
PHASES, AND STUDY TYPESETHICAL AND REGULATORY
REQUIREMENTS (IRB, FDA, ICH-GCP)INFORMED CONSENT
PROCESS AND PARTICIPANT RIGHTSSTUDY PROTOCOL
IMPLEMENTATION AND ADHERENCESUBJECT RECRUITMENT,
SCREENING, AND ENROLLMENT PROCEDURESDATA
COLLECTION, MANAGEMENT, AND QUALITY
ASSURANCESAFETY REPORTING, ADVERSE EVENT
DOCUMENTATION, AND MONITORINGINTERACTIONS WITH
SPONSORS, INVESTIGATORS, AND RESEARCH
STAFFPROFESSIONALISM, ETHICS, AND CONTINUOUS
EDUCATION IN CLINICAL RESEARCH
◍ A subject is issued 120 tablets and is instructed to take 2 tablets 4 times a
day. He returns 88 tablets on the morning of day 9 fasting for laboratory
tests. What percent compliant is he?.
Answer: 50%
◍ Twenty-six subjects were enrolled in a pneumonia trial. The site received
100 bottles of I
P. Each subject received two bottles. Four subjects did not return their trial
bottles. How many bottles are available for the CRC to return to the sponsor
, at the end of the trial?.
Answer: 92
◍ A subject is participating in a clinical trial where only the pharmacist and
the sponsor know the identity of the I
P. The pharmacist has no direct contact with the trial subject and the clinical
team. Which of the following BEST describes this trial type?.
Answer: double-blind
◍ double-blind trial.
Answer: study where participants and the study team interacting with them
(investigator, arc) are unaware of treatment allocation
◍ A clinical trial is being conducted to determine the safety and tolerability of
a new anti-emetic I
P. The sponsor expects to enroll 20 subjects. This would be considered a.
Answer: Phase 1 Trial
◍ Phase 1 Trials primary objective.
Answer: non-therapeutic objectives, intended to determine tolerability of
dose ranges for future trials, and determine the nature of adverse events that
may be expected
◍ Phase 1 trials typically have a ________ group of subjects enrolled..
Answer: small
◍ Open-label trial.
Answer: both the researchers and subjects know which treatment is being
administered
◍ Single-blind trial.
Answer: subjects are not aware of which treatment is administered,
researchers do know
◍ therapeutic efficacy.
Answer: ability of a treatment (drug, therapy) to produce its intended
beneficial effects
