Test Bank For
Robbins And Cotran Pathologic Basis Of
Disease
Author: Vinay Kumar
11th Edition
, Robbins And Cotran Pathologic Basis Of
Disease 11th Edition Kumar Test Bank
Chapter 02: Cellular Responses To Stress And Toxic Insults: Adaptation, Injury, And
Death MULTIPLE CHOICE
1. A 60-Year-Old Man Who Had Generalized Atherosclerosis Died 24 Hours After
Having A Stroke.
A Cerebral Infarct Was Found At Autopsy. Necrosis Of The Brain Is Classified As
a. Coagulative Necrosis
b. Liquefactive Necrosis
c. Fat Necrosis
d. Fibrinoid Necrosis
e. Caseous Necrosis
ANS: B, Brain Infarcts Are Characterized By Liquefactive Necrosis.
2. A 30-Year-Old Woman Who Had Leukemia Was Treated With Bone Marrow
Transplantation. She Developed A Skin Rash That Was Interpreted As A Sign Of A
Graft-Versus- Host Reaction. A Skin Biopsy Was Performed. In The Epidermis,
There Were Scattered Dead Epidermal Cells That Had Rounded Contours And
Pyknotic Nuclei. This Form Of Cell Death Is Caused By
a. Activation Of Caspases Throtue
ghsT
reb
ceapn
tokr S
traenlsm
le
ittred.Scigonm
als On The Cell Surface
b. Inhibition Of Atpase
c. Inhibition Of Oxidative Phosphorylation
d. Activation Of Lysosomal Enzymes
e. Depletion Of Glycogen
ANS: A, Graft-Versus-Host–Induced Cell Death In The Epidermis Is A Form Of
Apoptosis. It Is Mediated By Caspases And Other Enzymes Of The Suicide Pathway Of
"Programmed Cell Death."
3. Uptake Of Bacteria Into The Cytoplasm Of Neutrophilic Leukocytes Is Called
a. Autophagocytosis
b. Heterophagocytosis
c. Exocytosis
d. Pinocytosis
e. Involution
ANS: B, Uptake Of Bacteria And Other Exogenous Particulate Material Into The
Phagosomes Is Called Phagocytosis.
,4. A 90-Year-Old Man Died In A Nursing Home. During The Past 10 Years, He Was
Unable To Care For Himself And Was Mentally Incoherent. He Had No Memory And
Could Not Hold A Conversation. He Was Unaware Of His Surroundings. At Autopsy,
The Brain Showed Signs Of Alzheimer Disease, And There Were Neurons
Containing Numerous Neurofibrillary Tangles. These Cytoplasmic Structures Are
Formed From Which Component Of The Neurons?
a. Nucleus
b. Rough Endoplasmic Reticulum
c. Smooth Endoplasmic Reticulum
d. Mitochondria
e. Cytoskeleton
ANS: E, Neurofibrillary Tangles Are Composed Of Microtubule-Associated Proteins And
Neurofilaments, Which Form The Cytoskeleton Of Nerve Cells.
5. Continuous Expression Of The Gene For Atrial Natriuretic Factor In The
Myocardial Cells Of The Left Ventricle Is Typically A Consequence Of
a. Myocardial Infarction
b. Angina Pectoris
c. Hypertension
d. Hypotension
e. Ventricular Fibrillation
ANS: C, Atrial Natriuretic Factor (ANF) Is Produced During Fetal Life In Both The
Atrial And Ventricular Cells Of The Heart. T
ae
ftesrtbb
irtahn
, Tk
hesaenlf E
gern.E Cr eomma i n s Active
Only In The Atrium, But Can Be Activated In Ventricular Cells Undergoing
Hypertrophy. Arterial Hypertension Is The Most Common Cause Of Ventricular
Hypertrophy.
6. Ubiquitin-Proteasome Degradation Of Plasma Proteins Is Opposed By
a. Insulin
b. Interleukin-1
c. Tumor Necrosis Factor Α
d. Glucocorticoids
e. Thyroid Hormones
ANS: A, Insulin Can Oppose Ubiquitin-Proteasome Degradation Of Plasma
Proteins, Whereas All Other Hormones And Mediators Of Inflammation Listed Here
Accelerate It.
7. A 28-Year-Old Man Was Found To Have Cirrhosis Of The Liver And Pulmonary
Emphysema. The Liver Cells Contained Globular Inclusions In Their Cytoplasm,
Which By Electron Microscopy Are Shown To Be Located Inside The
a. Golgi Apparatus
b. Smooth Endoplasmic Reticulum
c. Rough Endoplasmic Reticulum
d. Mitochondria
e. Peroxisomes
, 1-3
ANS: C, The Clinical History (I.E., The Concurrence Of Cirrhosis And Pulmonary
Emphysema) Suggests That This Young Man Has 1-Antitrypsin (AAT) Deficiency.
The Cytoplasmic Globules In The Liver Cells Represent Misfolded AAT, Which
Cannot Be Excreted From The Liver Cells And Remains Inside The Liver Cells In
The Dilated Cisterns Of The Rough Endoplasmic Reticulum.
8. A 60-Year-Old Obese Man Was Admitted To The Hospital For Treatment Of
Alcoholism. He Has Diabetes Mellitus. A Liver Biopsy Was Performed, And The
Specimen Showed That The Liver Cells Contain Increased Amounts Of
a. Hemosiderin
b. Bile
c. Triglycerides
d. Bilirubin
e. Insulin
ANS: C, The Three Most Common Causes Of Fatty Liver Are Obesity, Alcoholism,
And Diabetes Mellitus. Fat Is Stored In The Liver Cells Predominantly In The Form
Of Triglycerides.
9. A 55-Year-Old Man Who Was On Renal Dialysis Was Admitted To The Hospital For
Evaluation Of Nausea And Vomiting. A Gastric Biopsy Was Performed. The Gastric
Mucosa Contained Foci Of Amorphous, Bluish (Basophilic) Material Forming
Aggregates 10-20 M In Diameter. These Aggregates Were Seen Mostly In The
Stroma Between The Foveolar Cells. No Other Abnormalities Were Seen, And The
Pathologist Concluded That These Changes Represent Evidence Of
a. Helicobacter Pylori Infection
b. Peptic Ulcer Formation
c. Dystrophic Calcification
d. Metastatic Calcification
e. Apoptosis
ANS: D, Bluish Material In The Stroma Of The Stomach Represents Foci Of
Calcification. In Patients Who Have Chronic Renal Disease, Such Calcifications
Occur In The Stomach, The Lungs, Or The Kidneys, And Are Classified As
Metastatic. Metastatic Calcifications Occur In Patients Who Have Hypercalcemia,
Which In This Patient Was Most Likely Caused By Secondary
Hyperparathyroidism.
Robbins And Cotran Pathologic Basis Of
Disease
Author: Vinay Kumar
11th Edition
, Robbins And Cotran Pathologic Basis Of
Disease 11th Edition Kumar Test Bank
Chapter 02: Cellular Responses To Stress And Toxic Insults: Adaptation, Injury, And
Death MULTIPLE CHOICE
1. A 60-Year-Old Man Who Had Generalized Atherosclerosis Died 24 Hours After
Having A Stroke.
A Cerebral Infarct Was Found At Autopsy. Necrosis Of The Brain Is Classified As
a. Coagulative Necrosis
b. Liquefactive Necrosis
c. Fat Necrosis
d. Fibrinoid Necrosis
e. Caseous Necrosis
ANS: B, Brain Infarcts Are Characterized By Liquefactive Necrosis.
2. A 30-Year-Old Woman Who Had Leukemia Was Treated With Bone Marrow
Transplantation. She Developed A Skin Rash That Was Interpreted As A Sign Of A
Graft-Versus- Host Reaction. A Skin Biopsy Was Performed. In The Epidermis,
There Were Scattered Dead Epidermal Cells That Had Rounded Contours And
Pyknotic Nuclei. This Form Of Cell Death Is Caused By
a. Activation Of Caspases Throtue
ghsT
reb
ceapn
tokr S
traenlsm
le
ittred.Scigonm
als On The Cell Surface
b. Inhibition Of Atpase
c. Inhibition Of Oxidative Phosphorylation
d. Activation Of Lysosomal Enzymes
e. Depletion Of Glycogen
ANS: A, Graft-Versus-Host–Induced Cell Death In The Epidermis Is A Form Of
Apoptosis. It Is Mediated By Caspases And Other Enzymes Of The Suicide Pathway Of
"Programmed Cell Death."
3. Uptake Of Bacteria Into The Cytoplasm Of Neutrophilic Leukocytes Is Called
a. Autophagocytosis
b. Heterophagocytosis
c. Exocytosis
d. Pinocytosis
e. Involution
ANS: B, Uptake Of Bacteria And Other Exogenous Particulate Material Into The
Phagosomes Is Called Phagocytosis.
,4. A 90-Year-Old Man Died In A Nursing Home. During The Past 10 Years, He Was
Unable To Care For Himself And Was Mentally Incoherent. He Had No Memory And
Could Not Hold A Conversation. He Was Unaware Of His Surroundings. At Autopsy,
The Brain Showed Signs Of Alzheimer Disease, And There Were Neurons
Containing Numerous Neurofibrillary Tangles. These Cytoplasmic Structures Are
Formed From Which Component Of The Neurons?
a. Nucleus
b. Rough Endoplasmic Reticulum
c. Smooth Endoplasmic Reticulum
d. Mitochondria
e. Cytoskeleton
ANS: E, Neurofibrillary Tangles Are Composed Of Microtubule-Associated Proteins And
Neurofilaments, Which Form The Cytoskeleton Of Nerve Cells.
5. Continuous Expression Of The Gene For Atrial Natriuretic Factor In The
Myocardial Cells Of The Left Ventricle Is Typically A Consequence Of
a. Myocardial Infarction
b. Angina Pectoris
c. Hypertension
d. Hypotension
e. Ventricular Fibrillation
ANS: C, Atrial Natriuretic Factor (ANF) Is Produced During Fetal Life In Both The
Atrial And Ventricular Cells Of The Heart. T
ae
ftesrtbb
irtahn
, Tk
hesaenlf E
gern.E Cr eomma i n s Active
Only In The Atrium, But Can Be Activated In Ventricular Cells Undergoing
Hypertrophy. Arterial Hypertension Is The Most Common Cause Of Ventricular
Hypertrophy.
6. Ubiquitin-Proteasome Degradation Of Plasma Proteins Is Opposed By
a. Insulin
b. Interleukin-1
c. Tumor Necrosis Factor Α
d. Glucocorticoids
e. Thyroid Hormones
ANS: A, Insulin Can Oppose Ubiquitin-Proteasome Degradation Of Plasma
Proteins, Whereas All Other Hormones And Mediators Of Inflammation Listed Here
Accelerate It.
7. A 28-Year-Old Man Was Found To Have Cirrhosis Of The Liver And Pulmonary
Emphysema. The Liver Cells Contained Globular Inclusions In Their Cytoplasm,
Which By Electron Microscopy Are Shown To Be Located Inside The
a. Golgi Apparatus
b. Smooth Endoplasmic Reticulum
c. Rough Endoplasmic Reticulum
d. Mitochondria
e. Peroxisomes
, 1-3
ANS: C, The Clinical History (I.E., The Concurrence Of Cirrhosis And Pulmonary
Emphysema) Suggests That This Young Man Has 1-Antitrypsin (AAT) Deficiency.
The Cytoplasmic Globules In The Liver Cells Represent Misfolded AAT, Which
Cannot Be Excreted From The Liver Cells And Remains Inside The Liver Cells In
The Dilated Cisterns Of The Rough Endoplasmic Reticulum.
8. A 60-Year-Old Obese Man Was Admitted To The Hospital For Treatment Of
Alcoholism. He Has Diabetes Mellitus. A Liver Biopsy Was Performed, And The
Specimen Showed That The Liver Cells Contain Increased Amounts Of
a. Hemosiderin
b. Bile
c. Triglycerides
d. Bilirubin
e. Insulin
ANS: C, The Three Most Common Causes Of Fatty Liver Are Obesity, Alcoholism,
And Diabetes Mellitus. Fat Is Stored In The Liver Cells Predominantly In The Form
Of Triglycerides.
9. A 55-Year-Old Man Who Was On Renal Dialysis Was Admitted To The Hospital For
Evaluation Of Nausea And Vomiting. A Gastric Biopsy Was Performed. The Gastric
Mucosa Contained Foci Of Amorphous, Bluish (Basophilic) Material Forming
Aggregates 10-20 M In Diameter. These Aggregates Were Seen Mostly In The
Stroma Between The Foveolar Cells. No Other Abnormalities Were Seen, And The
Pathologist Concluded That These Changes Represent Evidence Of
a. Helicobacter Pylori Infection
b. Peptic Ulcer Formation
c. Dystrophic Calcification
d. Metastatic Calcification
e. Apoptosis
ANS: D, Bluish Material In The Stroma Of The Stomach Represents Foci Of
Calcification. In Patients Who Have Chronic Renal Disease, Such Calcifications
Occur In The Stomach, The Lungs, Or The Kidneys, And Are Classified As
Metastatic. Metastatic Calcifications Occur In Patients Who Have Hypercalcemia,
Which In This Patient Was Most Likely Caused By Secondary
Hyperparathyroidism.
