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NCLEX-RN Pharmacology Practice Questions and Answers 2025 | Nursing Drug Review with Rationales

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Master nursing pharmacology with this NCLEX-RN pharmacology practice guide. This document includes NCLEX-style medication questions with correct answers and rationales to help students review drug classes, side effects, nursing interventions, contraindications, and patient teaching. Topics include cardiovascular medications, antibiotics, insulin, anticoagulants, diuretics, pain medications, psychiatric medications, respiratory drugs, and emergency medications. Perfect for NCLEX-RN review, nursing pharmacology exams, ATI, HESI, and nursing school test preparation.

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NCLEX Practice Questions

After receiving report at the start of the evening shift, which of the
following clients should the nurse attend to first?


(a) A 34-year-old man undergoing treatment for non-Hodgkin
lymphoma with a potassium level of 7.5 mEq/L.
(b) A 21-year-old woman with sickle cell anemia with pain of 6 on a
scale of 1-10.
(c) A 55-year-old woman with ovarian cancer waiting to be discharged.
(d) A 72-year-old man with chronic obstructive pulmonary disease
(COPD) and a pulse oximetry of 96% on room air. - -Correct Answer-
Correct Answer: (a) A 34-year-old man undergoing treatment for non-
Hodgkin lymphoma with a potassium level of 7.5 mEq/L.


Rationale: Hyperkalemia is a potentially serious condition that, in a
client undergoing treatment for non-Hodgkin lymphoma, could indicate
tumour lysis syndrome. Patient (b) should be attended to, but her
condition is not as urgent. Patients (c) and (d) do not require immediate
attention.


A 34-year-old woman who developed Stevens-Johnson syndrome
while undergoing treatment with carbamazepine (Tegretol) is being
transferred in stable condition from the intensive care unit to the
medical unit. There are 4 beds available. The nurse knows the best
choice of roommates for this client is which of the following?


(a) A 40-year-old man with methicillin-resistant Staphylococcus
aureus (MRSA).
(b) A 28-year-old woman diagnosed with diarrhea.


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(c) A 72-year-old man with fever of unknown origin.
(d) A 68-year-old woman with atrial fibrillation . - -Correct Answer-
Correct Answer: (d) A 68-year-old woman with atrial fibrillation.


Rationale: A client with Stevens-Johnson syndrome is likely to have
severe skin integrity issues, including blistering and skin shedding,
which can place the client at high risk for infection. Atrial fibrillation is
not an infectious process. All other patients may be an infection risk for
an individual with altered skin integrity.


A 72-year-old man who had a stroke is being transferred from a
medical unit to a rehabilitation centre. The nurse case manager is
assisting in the process. The nurse knows that the goals of case
management include which of the following? Select all that apply.


(a) Improving the coordination of care
(b) Increasing referrals to local organizations
(c) Reducing the fragmentation of care
(d) Discharging clients quickly - -Correct Answer-Correct Answer: (a)
Improving the coordination of care; and (c) Reducing the fragmentation
of care


Rationale: Some of the primary goals of case management are to
improve the coordination of care and to reduce fragmentation of care.
The other options are not goals of case management.


A pregnant woman at 15 weeks' gestation is scheduled for an
amniocentesis. As the client is being prepped for the procedure, it
becomes clear to the nurse that the client doesn't fully understand the
risks and benefits associated with the procedure. Which of the following
describe the nurse's role in obtaining informed consent? Select all that
apply.

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