SAFM AFMC Level 1 Exam UPDATED
ACTUAL QUESTIONS AND CORRECT
ANSWERS
_________________ is about the biotransformation of substances that allows for their transport and
excretion.This includes mobilization of stored toxins (e.g. heavy metals) from within tissues -
CORRECT ANSWER detoxification
Various drugs/foods/herbs may also affect detoxication capacity/efficacy in one or both of two ways: -
CORRECT ANSWER directly modify, monopolize
Reactive intermediaries create Oxidative damage!
Retention of toxins (e.g. heavy metals, excessive level of drug metabolites)
Phase 1:2 imbalance and Phase 2 conjugation both need glutathione (e.g. for heavy metal
detoxification and Phase 2 uses prevents "recycling"). - CORRECT ANSWER Phase 1 and
Phase 2 imbalance
Caffeine, Excessive alcohol, Cigarette smoke, Charred meat, many common medications, higher
insulin - CORRECT ANSWER Phase 1 upregulators
Cruciferous vegetables, B-vitamins, eggs, healthy digestion, sufficient sleep, low insulin (low-
glycemic diet, managed stress, minimal oxidative damage - CORRECT ANSWER Phase 2
upregulators
Imbalance in the activity of Phase 1 and 2 enzymes leads to ____________ that could finally bind
macromolecues such as DNA to cause mutation, lipid to cause membrane damage, or proteins to alter
their acitivies. - CORRECT ANSWER shifting of equilibrium toward free radical generation
Thoughts, neural & immune tissue - CORRECT ANSWER Hypothalamus
Environment, neural & endocrine tissue - CORRECT ANSWER Pituitary
Stress/Immunity, endocrine tissue - CORRECT ANSWER Adrenal
ACTUAL QUESTIONS AND CORRECT
ANSWERS
_________________ is about the biotransformation of substances that allows for their transport and
excretion.This includes mobilization of stored toxins (e.g. heavy metals) from within tissues -
CORRECT ANSWER detoxification
Various drugs/foods/herbs may also affect detoxication capacity/efficacy in one or both of two ways: -
CORRECT ANSWER directly modify, monopolize
Reactive intermediaries create Oxidative damage!
Retention of toxins (e.g. heavy metals, excessive level of drug metabolites)
Phase 1:2 imbalance and Phase 2 conjugation both need glutathione (e.g. for heavy metal
detoxification and Phase 2 uses prevents "recycling"). - CORRECT ANSWER Phase 1 and
Phase 2 imbalance
Caffeine, Excessive alcohol, Cigarette smoke, Charred meat, many common medications, higher
insulin - CORRECT ANSWER Phase 1 upregulators
Cruciferous vegetables, B-vitamins, eggs, healthy digestion, sufficient sleep, low insulin (low-
glycemic diet, managed stress, minimal oxidative damage - CORRECT ANSWER Phase 2
upregulators
Imbalance in the activity of Phase 1 and 2 enzymes leads to ____________ that could finally bind
macromolecues such as DNA to cause mutation, lipid to cause membrane damage, or proteins to alter
their acitivies. - CORRECT ANSWER shifting of equilibrium toward free radical generation
Thoughts, neural & immune tissue - CORRECT ANSWER Hypothalamus
Environment, neural & endocrine tissue - CORRECT ANSWER Pituitary
Stress/Immunity, endocrine tissue - CORRECT ANSWER Adrenal
