MMSC 407 CLINICAL CHEMISTRY ACTUAL
EXAM PAPER 2026 FULL QUESTIONS AND
CORRECT ANSWERS GRADED A+
●● T/F Hemoglobin S is a variant (mutation) form of Hemoglobin A
Answer: True
●● What is the mutation that causes HbS Answer: Beta E6V
●● MC Reduced amounts of hemoglobin A are found in all of these
EXCEPT:
A. Beta thalassemia
B. Sickle cell anemia
C. Alpha thalassemia
D. Hemoglobin S/beta thal Answer: B. Sickle cell anemia
●● The finding of hemoglobin Barts indicates Answer: Alpha
thalassemia
●● What caveat would apply to collection or recollection of newborn
blood spots for hemoglobin electrophoresis Answer: Transfusion
,●● Diagnosis of congenital hypothyroidism Answer: Decreased
thyroxine, increased thyroid stimulating hormone
●● Where is TSH produced Answer: Anterior pituitray
●● Another name for thyroxine is Answer: T4
●● A person with primary hypothyroidism will have Answer: An
elevated TSH
●● What is the most commonly found mutation causing cystic fibrosis
Answer: Delta F508
●● MC Cystic fibrosis is
A. Autosomal dominant
B. Autosomal recessive
C. X linked Answer: B. Autosomal recessive
●● Cystic fibrosis is predominately found in Answer: European
Americans
●● What is the correct order for newborn testing for CF Answer: IRT -->
DNA testing --> sweat testing
, ●● What is an example of a nonsense mutation Answer: R553X
●● What cholinergic agent is used to elicit sweating Answer: Pilocarpine
●● T/F Sweat chloride is actually a better test than sweat conductivity
Answer: True
●● MC Which of these hormones is not produced in the adrenal cortex
A. Aldosterone
B. Cortisol
C. Testosterone
D. Thyroxine Answer: D. Thyroxine
●● CAH is suspected when ______ is increased at newborn screening
Answer: 17-OH progesterone
●● The most common type of congenital adrenal hyperplasia associated
with increased plasma concentrations of 17-a-hydroxyprogesterone and
increased urinary excretion of pregnaneutriol is Answer: 21-hydroxylase
deficiency
●● Salt wasting syndrome and dehydration in CAH is due to the
deficiency of Answer: Aldosterone
EXAM PAPER 2026 FULL QUESTIONS AND
CORRECT ANSWERS GRADED A+
●● T/F Hemoglobin S is a variant (mutation) form of Hemoglobin A
Answer: True
●● What is the mutation that causes HbS Answer: Beta E6V
●● MC Reduced amounts of hemoglobin A are found in all of these
EXCEPT:
A. Beta thalassemia
B. Sickle cell anemia
C. Alpha thalassemia
D. Hemoglobin S/beta thal Answer: B. Sickle cell anemia
●● The finding of hemoglobin Barts indicates Answer: Alpha
thalassemia
●● What caveat would apply to collection or recollection of newborn
blood spots for hemoglobin electrophoresis Answer: Transfusion
,●● Diagnosis of congenital hypothyroidism Answer: Decreased
thyroxine, increased thyroid stimulating hormone
●● Where is TSH produced Answer: Anterior pituitray
●● Another name for thyroxine is Answer: T4
●● A person with primary hypothyroidism will have Answer: An
elevated TSH
●● What is the most commonly found mutation causing cystic fibrosis
Answer: Delta F508
●● MC Cystic fibrosis is
A. Autosomal dominant
B. Autosomal recessive
C. X linked Answer: B. Autosomal recessive
●● Cystic fibrosis is predominately found in Answer: European
Americans
●● What is the correct order for newborn testing for CF Answer: IRT -->
DNA testing --> sweat testing
, ●● What is an example of a nonsense mutation Answer: R553X
●● What cholinergic agent is used to elicit sweating Answer: Pilocarpine
●● T/F Sweat chloride is actually a better test than sweat conductivity
Answer: True
●● MC Which of these hormones is not produced in the adrenal cortex
A. Aldosterone
B. Cortisol
C. Testosterone
D. Thyroxine Answer: D. Thyroxine
●● CAH is suspected when ______ is increased at newborn screening
Answer: 17-OH progesterone
●● The most common type of congenital adrenal hyperplasia associated
with increased plasma concentrations of 17-a-hydroxyprogesterone and
increased urinary excretion of pregnaneutriol is Answer: 21-hydroxylase
deficiency
●● Salt wasting syndrome and dehydration in CAH is due to the
deficiency of Answer: Aldosterone
