UNITED STATES MEDICAL LICENSING EXAMINATION (USMLE) Comprehensive Question Bank
UNITED STATES MEDICAL
LICENSING EXAMINATION
(USMLE)
STEP 1 | STEP 2 CK | STEP 3 COMPREHENSIVE QUESTION BANK
All Major Disciplines Covered 250+ High-Yield Practice Questions
Detailed Answer Explanations Board-Style Format
Anatomy Physiology Biochemistry Pathology
Pharmacology Microbiology Immunology Genetics
Cardiology Nephrology Neurology Psychiatry
Behavioral Science Biostatistics Endocrinology Pulmonology
Gastroenterology Hematology Obstetrics Pediatrics
Surgery Dermatology Rheumatology Infectious Disease
Comprehensive Review Edition | For Educational Purposes Only
USMLE Step 1, 2 & 3 | Comprehensive Review Page 1 of 249 For Educational Purposes Only
,UNITED STATES MEDICAL LICENSING EXAMINATION (USMLE) Comprehensive Question Bank
TABLE OF CONTENTS
Chapter 01 — Anatomy 50 Questions
Chapter 02 — Physiology 50 Questions
Chapter 03 — Biochemistry 50 Questions
Chapter 04 — Pathology 50 Questions
Chapter 05 — Pharmacology 50 Questions
Chapter 06 — Microbiology 50 Questions
Chapter 07 — Immunology 25 Questions
Chapter 08 — Behavioral Science 25 Questions
Chapter 09 — Biostatistics 25 Questions
Chapter 10 — Genetics 15 Questions
Chapter 11 — Neuroanatomy 10 Questions
Chapter 12 — Cardiology 10 Questions
Chapter 13 — Nephrology 5 Questions
Chapter 14 — Gastroenterology 5 Questions
Chapter 15 — Endocrinology 5 Questions
Chapter 16 — Hematology 5 Questions
Chapter 17 — Pulmonology 5 Questions
Chapter 18 — Dermatology 5 Questions
USMLE Step 1, 2 & 3 | Comprehensive Review Page 2 of 249 For Educational Purposes Only
,UNITED STATES MEDICAL LICENSING EXAMINATION (USMLE) Comprehensive Question Bank
Chapter 19 — Rheumatology 5 Questions
Chapter 20 — Infectious Disease 5 Questions
Chapter 21 — Obstetrics 5 Questions
Chapter 22 — Pediatrics 5 Questions
Chapter 23 — Surgery 5 Questions
Chapter 24 — Psychiatry 5 Questions
Chapter 25 — Neurology 5 Questions
Chapter 26 — Toxicology 5 Questions
USMLE Step 1, 2 & 3 | Comprehensive Review Page 3 of 249 For Educational Purposes Only
, UNITED STATES MEDICAL LICENSING EXAMINATION (USMLE) Comprehensive Question Bank
INTRODUCTION & HOW TO USE THIS BOOK
About This Question Bank
This comprehensive USMLE question bank has been carefully compiled to assist medical students and
graduates preparing for the United States Medical Licensing Examinations (USMLE Steps 1, 2 CK, and 3).
The questions herein are designed in the board-style single best answer (SBA) format used on actual
USMLE examinations, emphasizing integrated clinical reasoning, pathophysiology, and patient
management.
Structure of Each Question
Each question presents a clinical vignette followed by five answer choices labeled A through E. A single
best answer is provided, along with a comprehensive explanation that not only justifies the correct answer
but also clarifies why the other options are incorrect. This approach reinforces understanding of key
concepts.
USMLE Exam Overview
The USMLE is a three-step examination for medical licensure in the United States:
Step 1 assesses understanding and application of foundational sciences (Anatomy, Biochemistry,
Physiology, Pathology, Pharmacology, Microbiology, and Behavioral Sciences). It is a one-day
computer-based exam with 280 questions.
Step 2 CK (Clinical Knowledge) tests medical knowledge, skills, and understanding of clinical science
essential for the supervised practice of medicine. It comprises 318 questions.
Step 3 assesses whether medical knowledge and understanding of biomedical, clinical, and social
sciences can be applied to the unsupervised practice of medicine, with emphasis on patient management
in ambulatory settings.
Study Strategy Recommendations
For optimal preparation: (1) Simulate exam conditions — read each question once and commit to an
answer before reading the explanation. (2) Review all explanations, including for correct answers. (3)
Create flashcards for high-yield facts. (4) Space your review using active recall. (5) Track weak areas by
subject and revisit them. (6) Integrate this question bank with a comprehensive review textbook and
clinical experience.
Disclaimer
USMLE Step 1, 2 & 3 | Comprehensive Review Page 4 of 249 For Educational Purposes Only
UNITED STATES MEDICAL
LICENSING EXAMINATION
(USMLE)
STEP 1 | STEP 2 CK | STEP 3 COMPREHENSIVE QUESTION BANK
All Major Disciplines Covered 250+ High-Yield Practice Questions
Detailed Answer Explanations Board-Style Format
Anatomy Physiology Biochemistry Pathology
Pharmacology Microbiology Immunology Genetics
Cardiology Nephrology Neurology Psychiatry
Behavioral Science Biostatistics Endocrinology Pulmonology
Gastroenterology Hematology Obstetrics Pediatrics
Surgery Dermatology Rheumatology Infectious Disease
Comprehensive Review Edition | For Educational Purposes Only
USMLE Step 1, 2 & 3 | Comprehensive Review Page 1 of 249 For Educational Purposes Only
,UNITED STATES MEDICAL LICENSING EXAMINATION (USMLE) Comprehensive Question Bank
TABLE OF CONTENTS
Chapter 01 — Anatomy 50 Questions
Chapter 02 — Physiology 50 Questions
Chapter 03 — Biochemistry 50 Questions
Chapter 04 — Pathology 50 Questions
Chapter 05 — Pharmacology 50 Questions
Chapter 06 — Microbiology 50 Questions
Chapter 07 — Immunology 25 Questions
Chapter 08 — Behavioral Science 25 Questions
Chapter 09 — Biostatistics 25 Questions
Chapter 10 — Genetics 15 Questions
Chapter 11 — Neuroanatomy 10 Questions
Chapter 12 — Cardiology 10 Questions
Chapter 13 — Nephrology 5 Questions
Chapter 14 — Gastroenterology 5 Questions
Chapter 15 — Endocrinology 5 Questions
Chapter 16 — Hematology 5 Questions
Chapter 17 — Pulmonology 5 Questions
Chapter 18 — Dermatology 5 Questions
USMLE Step 1, 2 & 3 | Comprehensive Review Page 2 of 249 For Educational Purposes Only
,UNITED STATES MEDICAL LICENSING EXAMINATION (USMLE) Comprehensive Question Bank
Chapter 19 — Rheumatology 5 Questions
Chapter 20 — Infectious Disease 5 Questions
Chapter 21 — Obstetrics 5 Questions
Chapter 22 — Pediatrics 5 Questions
Chapter 23 — Surgery 5 Questions
Chapter 24 — Psychiatry 5 Questions
Chapter 25 — Neurology 5 Questions
Chapter 26 — Toxicology 5 Questions
USMLE Step 1, 2 & 3 | Comprehensive Review Page 3 of 249 For Educational Purposes Only
, UNITED STATES MEDICAL LICENSING EXAMINATION (USMLE) Comprehensive Question Bank
INTRODUCTION & HOW TO USE THIS BOOK
About This Question Bank
This comprehensive USMLE question bank has been carefully compiled to assist medical students and
graduates preparing for the United States Medical Licensing Examinations (USMLE Steps 1, 2 CK, and 3).
The questions herein are designed in the board-style single best answer (SBA) format used on actual
USMLE examinations, emphasizing integrated clinical reasoning, pathophysiology, and patient
management.
Structure of Each Question
Each question presents a clinical vignette followed by five answer choices labeled A through E. A single
best answer is provided, along with a comprehensive explanation that not only justifies the correct answer
but also clarifies why the other options are incorrect. This approach reinforces understanding of key
concepts.
USMLE Exam Overview
The USMLE is a three-step examination for medical licensure in the United States:
Step 1 assesses understanding and application of foundational sciences (Anatomy, Biochemistry,
Physiology, Pathology, Pharmacology, Microbiology, and Behavioral Sciences). It is a one-day
computer-based exam with 280 questions.
Step 2 CK (Clinical Knowledge) tests medical knowledge, skills, and understanding of clinical science
essential for the supervised practice of medicine. It comprises 318 questions.
Step 3 assesses whether medical knowledge and understanding of biomedical, clinical, and social
sciences can be applied to the unsupervised practice of medicine, with emphasis on patient management
in ambulatory settings.
Study Strategy Recommendations
For optimal preparation: (1) Simulate exam conditions — read each question once and commit to an
answer before reading the explanation. (2) Review all explanations, including for correct answers. (3)
Create flashcards for high-yield facts. (4) Space your review using active recall. (5) Track weak areas by
subject and revisit them. (6) Integrate this question bank with a comprehensive review textbook and
clinical experience.
Disclaimer
USMLE Step 1, 2 & 3 | Comprehensive Review Page 4 of 249 For Educational Purposes Only
