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TEST BANK FOR
Biochemistry, An Integrative Approach with
Expanded Topics, 1st Edition (Tansey, 2020)
Chapter 1-25 | All Chapters
,Table of Contents
Chapter 1: The Chemical Foundations of Biochemistry
Chapter 2: Nucleic Acids
Chapter 3: Proteins I: An Introduction to Protein Structure, Function and Purification
Chapter 4: Proteins II: Enzymes
Chapter 5: Membranes and an Introduction to Signal Transduction
Chapter 6: Carbohydrates I: Mono- and Disaccharides, Glycolysis, Gluconeogenesis, and the Fates of
Pyruvate
Chapter 7: The Common Catabolic Pathway
Chapter 8: Carbohydrates II: Glycogen Metabolism, Pentose Phosphate Pathway, and Glycoconjugates
Chapter 9: Lipids I: Fatty Acids, Steroids, and Eicosanoids; Beta-Oxidation and Fatty Acid Biosynthesis
Chapter 10: Lipids II: Metabolism and Transport of Complex Lipids
Chapter 11: Amine Metabolism
Chapter 12: Metabolism Integration
Chapter 13: Nucleotide & Deoxynucleotide Metabolism
Chapter 14: DNA Replication, Damage and Repair
Chapter 15: RNA Synthesis And Processing
Chapter 16: Protein Synthesis
Chapter 17: Control Of Gene Expression
Chapter 18: Determination of Macromolecular Structure
Chapter 19: Allosterism and Receptor-Ligand Interactions
Chapter 20: Designer Proteins and Protein Folding
Chapter 21: Biomolecule Purification
Chapter 22: Bioinformatics and Omics
Chapter 23: Signal Transduction
Chapter 24: Protein Trafficking
Chapter 25: Photosynthesis & Nitrogen Fixation
,Test Bank – Chapter 1
The Chemical Foundations of Biochemistry
Multiple Choice Questions (25 Questions)
1. Which of the following bonds is primarily responsible for the high specific heat
capacity of water?
a) Covalent bonds
b) Ionic bonds
c) Hydrogen bonds
d) Van der Waals interactions
e) Hydrophobic interactions
Correct Answer: c
Explanation: Hydrogen bonds between water molecules require significant energy to
break, giving water a high specific heat capacity. This allows water to resist temperature
changes, which is critical for maintaining stable conditions in biological systems.
2. A solution has a pH of 4.5. What is its hydrogen ion concentration [H¼]?
a) 4.5 × 10½¶ M
b) 3.16 × 10½· M
c) 4.5 × 10½· M
d) 3.16 × 10½¶ M
e) 5.0 × 10½¶ M
, Correct Answer: b
Explanation: pH = -log[H¼], so [H¼] = 10^(-pH) = 10^(-4.5) = 3.16 × 10½· M. This
calculation is fundamental for understanding cellular pH environments.
3. Which weak acid would be most effective as a buffer at pH 6.8?
a) Acetic acid (pKa = 4.76)
b) Carbonic acid (pKa₁ = 6.35)
c) Phosphoric acid (pKa₁ = 2.14)
d) Tris-HCl (pKa = 8.10)
e) Lactic acid (pKa = 3.86)
Correct Answer: b
Explanation: A buffer is most effective within ±1 pH unit of its pKa. Carbonic acid has
pKa = 6.35, which is closest to pH 6.8, making it the best choice for buffering at that pH.
4. The hydrophobic effect is primarily driven by:
a) Strong attraction between nonpolar molecules
b) Covalent bonding between hydrocarbon chains
c) Entropic increase of water molecules
d) Ionic interactions between water and solutes
e) Hydrogen bonding between nonpolar groups
Correct Answer: c
Explanation: Nonpolar molecules disrupt the hydrogen-bonded network of water. Water
molecules reorder around them, decreasing entropy. Clustering of hydrophobic
molecules minimizes this ordered water, increasing entropy, which thermodynamically
drives the hydrophobic effect.
TEST BANK FOR
Biochemistry, An Integrative Approach with
Expanded Topics, 1st Edition (Tansey, 2020)
Chapter 1-25 | All Chapters
,Table of Contents
Chapter 1: The Chemical Foundations of Biochemistry
Chapter 2: Nucleic Acids
Chapter 3: Proteins I: An Introduction to Protein Structure, Function and Purification
Chapter 4: Proteins II: Enzymes
Chapter 5: Membranes and an Introduction to Signal Transduction
Chapter 6: Carbohydrates I: Mono- and Disaccharides, Glycolysis, Gluconeogenesis, and the Fates of
Pyruvate
Chapter 7: The Common Catabolic Pathway
Chapter 8: Carbohydrates II: Glycogen Metabolism, Pentose Phosphate Pathway, and Glycoconjugates
Chapter 9: Lipids I: Fatty Acids, Steroids, and Eicosanoids; Beta-Oxidation and Fatty Acid Biosynthesis
Chapter 10: Lipids II: Metabolism and Transport of Complex Lipids
Chapter 11: Amine Metabolism
Chapter 12: Metabolism Integration
Chapter 13: Nucleotide & Deoxynucleotide Metabolism
Chapter 14: DNA Replication, Damage and Repair
Chapter 15: RNA Synthesis And Processing
Chapter 16: Protein Synthesis
Chapter 17: Control Of Gene Expression
Chapter 18: Determination of Macromolecular Structure
Chapter 19: Allosterism and Receptor-Ligand Interactions
Chapter 20: Designer Proteins and Protein Folding
Chapter 21: Biomolecule Purification
Chapter 22: Bioinformatics and Omics
Chapter 23: Signal Transduction
Chapter 24: Protein Trafficking
Chapter 25: Photosynthesis & Nitrogen Fixation
,Test Bank – Chapter 1
The Chemical Foundations of Biochemistry
Multiple Choice Questions (25 Questions)
1. Which of the following bonds is primarily responsible for the high specific heat
capacity of water?
a) Covalent bonds
b) Ionic bonds
c) Hydrogen bonds
d) Van der Waals interactions
e) Hydrophobic interactions
Correct Answer: c
Explanation: Hydrogen bonds between water molecules require significant energy to
break, giving water a high specific heat capacity. This allows water to resist temperature
changes, which is critical for maintaining stable conditions in biological systems.
2. A solution has a pH of 4.5. What is its hydrogen ion concentration [H¼]?
a) 4.5 × 10½¶ M
b) 3.16 × 10½· M
c) 4.5 × 10½· M
d) 3.16 × 10½¶ M
e) 5.0 × 10½¶ M
, Correct Answer: b
Explanation: pH = -log[H¼], so [H¼] = 10^(-pH) = 10^(-4.5) = 3.16 × 10½· M. This
calculation is fundamental for understanding cellular pH environments.
3. Which weak acid would be most effective as a buffer at pH 6.8?
a) Acetic acid (pKa = 4.76)
b) Carbonic acid (pKa₁ = 6.35)
c) Phosphoric acid (pKa₁ = 2.14)
d) Tris-HCl (pKa = 8.10)
e) Lactic acid (pKa = 3.86)
Correct Answer: b
Explanation: A buffer is most effective within ±1 pH unit of its pKa. Carbonic acid has
pKa = 6.35, which is closest to pH 6.8, making it the best choice for buffering at that pH.
4. The hydrophobic effect is primarily driven by:
a) Strong attraction between nonpolar molecules
b) Covalent bonding between hydrocarbon chains
c) Entropic increase of water molecules
d) Ionic interactions between water and solutes
e) Hydrogen bonding between nonpolar groups
Correct Answer: c
Explanation: Nonpolar molecules disrupt the hydrogen-bonded network of water. Water
molecules reorder around them, decreasing entropy. Clustering of hydrophobic
molecules minimizes this ordered water, increasing entropy, which thermodynamically
drives the hydrophobic effect.
