,Question 1
A patient has liver and kidney disease. He is given a medication with a half-life of 30 hours.
What is the expected duration of this medication?
A. increase.
B. decrease.
C. remain unchanged.
D. dissipate.
Correct Answer: A
Rationale: The duration of a medication is expected to increase in patients with liver and
kidney disease because these organs are primarily responsible for drug metabolism and
excretion. Impaired function slows drug clearance, prolonging the half-life and extending
the duration of action.
Question 2
A nurse is to administer a dose of furosemide (Lasix). The nurse is aware that Lasix is the
________ for the drug.
A. generic name
B. chemical name
C. nonproprietary name
D. brand name
Correct Answer: D
Rationale: Lasix is the brand name (also called trade name or proprietary name) for
furosemide. Brand names are capitalized and given by the manufacturer, while generic
names (furosemide) are lower case and nonproprietary.
Question 3
When assessing older adults and those with renal dysfunction, the nurse would expect the
creatinine clearance to be which of the following?
A. substantially increased.
B. slightly increased.
, C. decreased.
D. in the normal range.
Correct Answer: C
Rationale: Creatinine clearance is decreased in older adults and patients with renal
dysfunction because the kidneys lose function with age and disease. This reduction in
glomerular filtration rate means drugs that rely on renal excretion will accumulate and
require dose adjustment.
Question 4
A patient sustains significant burns to the skin and is experiencing fluid shift associated with
edema in the fluid overload phase. The nurse would anticipate that this will interfere most with
which phase of pharmacodynamics?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Correct Answer: B
Rationale: Edema and fluid shifts interfere most with drug distribution because the
movement of drugs from the bloodstream into tissues is altered. Increased fluid volume in
interstitial spaces can dilute drug concentrations and change how drugs reach their target
receptors.
Question 5
Which nursing actions would be most appropriate for ensuring patient safety with a medication
that has a low therapeutic index?
A. Monitoring a patient's urine output
B. Assessing vital signs hourly
C. Maintaining strict isolation precautions
D. Monitoring serum peak and trough levels
Correct Answer: D
A patient has liver and kidney disease. He is given a medication with a half-life of 30 hours.
What is the expected duration of this medication?
A. increase.
B. decrease.
C. remain unchanged.
D. dissipate.
Correct Answer: A
Rationale: The duration of a medication is expected to increase in patients with liver and
kidney disease because these organs are primarily responsible for drug metabolism and
excretion. Impaired function slows drug clearance, prolonging the half-life and extending
the duration of action.
Question 2
A nurse is to administer a dose of furosemide (Lasix). The nurse is aware that Lasix is the
________ for the drug.
A. generic name
B. chemical name
C. nonproprietary name
D. brand name
Correct Answer: D
Rationale: Lasix is the brand name (also called trade name or proprietary name) for
furosemide. Brand names are capitalized and given by the manufacturer, while generic
names (furosemide) are lower case and nonproprietary.
Question 3
When assessing older adults and those with renal dysfunction, the nurse would expect the
creatinine clearance to be which of the following?
A. substantially increased.
B. slightly increased.
, C. decreased.
D. in the normal range.
Correct Answer: C
Rationale: Creatinine clearance is decreased in older adults and patients with renal
dysfunction because the kidneys lose function with age and disease. This reduction in
glomerular filtration rate means drugs that rely on renal excretion will accumulate and
require dose adjustment.
Question 4
A patient sustains significant burns to the skin and is experiencing fluid shift associated with
edema in the fluid overload phase. The nurse would anticipate that this will interfere most with
which phase of pharmacodynamics?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Correct Answer: B
Rationale: Edema and fluid shifts interfere most with drug distribution because the
movement of drugs from the bloodstream into tissues is altered. Increased fluid volume in
interstitial spaces can dilute drug concentrations and change how drugs reach their target
receptors.
Question 5
Which nursing actions would be most appropriate for ensuring patient safety with a medication
that has a low therapeutic index?
A. Monitoring a patient's urine output
B. Assessing vital signs hourly
C. Maintaining strict isolation precautions
D. Monitoring serum peak and trough levels
Correct Answer: D
