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ESSENTIAL GENETICS: A GENOMIC PERSPECTIVE 4TH EDITION
Elizabeth W. Jones & Daniel L. Hartl
,Study Guide and Solutions Manual to accompany
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AGENOMICSPERSPECTIVE
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Fourth Edition qa
DanielL.HartlandElizabethW.Jones Prepar e
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dbyElenaR.Lozovsky
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JONES AND q a q a BARTLETT q a PUBLISHERS
Sudbury, Massachusetts
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BOSTON TORONTO LONDON SINGAPORE
,Contents
1 The Genetic Code of Genes and Genomes
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2 Transmission Genetics: Heritage from Mendel q a q a q a q a 4
3 The Chromosomal Basis of Heredity......................• ............................... 9
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4 Gene Linkage and Genetic Mapping.......................·.· ........................ 13
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5 Human Chromosomes and Chromosome Behavior
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6 DNA Structure, Replication, and Manipulation
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7 The Genetics of Bacteria and Their Viruses
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8 The Molecular Genetics of Gene Expression
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9 Molecular Mechanisms of Gene Regulation
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10 Genomics, Proteomics, and Genetic Engineering .............................. 38
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11 The Genetic Control of Development
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12 Molecular Mechanisms of Mutation and DNA Repair
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13 Molecular Genetics of the Cell Cycle and cancer
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14 Molecular Evolution and Population Genetics...............• ................ 52
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15 The Genetic Basis of Complex Inheritance
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Appendix: Answers q a 58
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, TheGeneticCodeofGenesand Ge a
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nomes
Key Concepts qa
• Inherited traits are affected by genes. qa qa q a qa qa
• Genes are composed of the chemical deoxyribonucleic acid (DNA).
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• DNA replicates to form (usually identical) copies of itself.
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• DNA contains a code specifying what types of enzymes and other proteins are mad e i
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n cells. qa
• DNA occasionally mutates, and the mutant forms specify altered proteins.
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• A mutant enzyme is an "inborn error of metabolism" that blocks one step in a bi o-
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chemical pathway for the metabolism of small molecules.
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• Traits are affected by environment as well as by genes.
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• Organisms change genetically through generations in the process of biologica l e
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volution.
• Because of their comm.on descent, organisms share many features of their genetics
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and biochemistry. qa
Key Terms qa
1. complementary base pairing q a q a
2. antiparallel
3. central dogma qa
4. transcri tion q a q a
5. ribosome
6. transfer RNA (tRNA) qa q a
7. proteome
8. substrate
9. alkaptonuria
10. phenylketonuria
11. pleiotropic effect or pleiotropy q a q a q a
12. prokaryote
Concepts in Action qa q a
1.1. (a) false; (b) true; (c) true; (d) false.
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1.2. The importance of the nucleus in inheritance was implied by its prominence in fe r-
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tilization. The discovery of chromosomes inside the nucleus, their behavior duri ng
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cell division, and the observation that each species has a characteristic chromos ome
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number made it likely that chromosomes were the carriers of the genes. Mic ro-
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scopic studies showed that DNA and proteins are both present in chromosomes, b
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ut whereas nearly all cells of a given species contain a constant amount of DN
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A, the amount and kinds of proteins differ greatly in different cell types.
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C 2006 by Jones and Bartlett Publishers
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ESSENTIAL GENETICS: A GENOMIC PERSPECTIVE 4TH EDITION
Elizabeth W. Jones & Daniel L. Hartl
,Study Guide and Solutions Manual to accompany
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q a s
AGENOMICSPERSPECTIVE
a
q qa
Fourth Edition qa
DanielL.HartlandElizabethW.Jones Prepar e
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dbyElenaR.Lozovsky
qa qa qa aq
JONES AND q a q a BARTLETT q a PUBLISHERS
Sudbury, Massachusetts
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BOSTON TORONTO LONDON SINGAPORE
,Contents
1 The Genetic Code of Genes and Genomes
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2 Transmission Genetics: Heritage from Mendel q a q a q a q a 4
3 The Chromosomal Basis of Heredity......................• ............................... 9
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4 Gene Linkage and Genetic Mapping.......................·.· ........................ 13
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5 Human Chromosomes and Chromosome Behavior
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6 DNA Structure, Replication, and Manipulation
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7 The Genetics of Bacteria and Their Viruses
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8 The Molecular Genetics of Gene Expression
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9 Molecular Mechanisms of Gene Regulation
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10 Genomics, Proteomics, and Genetic Engineering .............................. 38
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11 The Genetic Control of Development
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12 Molecular Mechanisms of Mutation and DNA Repair
q a q a qa q a q a q a 45
13 Molecular Genetics of the Cell Cycle and cancer
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14 Molecular Evolution and Population Genetics...............• ................ 52
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15 The Genetic Basis of Complex Inheritance
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Appendix: Answers q a 58
V
, TheGeneticCodeofGenesand Ge a
q qa
nomes
Key Concepts qa
• Inherited traits are affected by genes. qa qa q a qa qa
• Genes are composed of the chemical deoxyribonucleic acid (DNA).
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• DNA replicates to form (usually identical) copies of itself.
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• DNA contains a code specifying what types of enzymes and other proteins are mad e i
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n cells. qa
• DNA occasionally mutates, and the mutant forms specify altered proteins.
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• A mutant enzyme is an "inborn error of metabolism" that blocks one step in a bi o-
qa qa qa qa qa qa qa qa qa WQ qa qa qa qa qa qa
chemical pathway for the metabolism of small molecules.
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• Traits are affected by environment as well as by genes.
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• Organisms change genetically through generations in the process of biologica l e
qa qa qa qa qa qa qa qa qa qa qa
volution.
• Because of their comm.on descent, organisms share many features of their genetics
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and biochemistry. qa
Key Terms qa
1. complementary base pairing q a q a
2. antiparallel
3. central dogma qa
4. transcri tion q a q a
5. ribosome
6. transfer RNA (tRNA) qa q a
7. proteome
8. substrate
9. alkaptonuria
10. phenylketonuria
11. pleiotropic effect or pleiotropy q a q a q a
12. prokaryote
Concepts in Action qa q a
1.1. (a) false; (b) true; (c) true; (d) false.
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1.2. The importance of the nucleus in inheritance was implied by its prominence in fe r-
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tilization. The discovery of chromosomes inside the nucleus, their behavior duri ng
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cell division, and the observation that each species has a characteristic chromos ome
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number made it likely that chromosomes were the carriers of the genes. Mic ro-
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scopic studies showed that DNA and proteins are both present in chromosomes, b
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ut whereas nearly all cells of a given species contain a constant amount of DN
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A, the amount and kinds of proteins differ greatly in different cell types.
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C 2006 by Jones and Bartlett Publishers
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