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Candidate surname Other names
Centre Number Candidate Number
Pearson Edexcel International GCSE
Afternoon (Time: 1 hour 45 minutes) Paper
reference 4HB1/01R
Human Biology 🟐 🟐
UNIT: 4HB1
PAPER: 01R
You must have: Total Marks
Ruler
Candidates may use a calculator
Instructions
•• Use black ink or ball-point pen.
If pencil is used for diagrams/sketches/graphs it must be dark (HB or B).
• Fill in the boxes at the top of this page with your name,
centre number and candidate number.
• Answer all questions.
• Answer the questions in the spaces provided
– there may be more space than you need.
• Show all the steps in any calculations and state the units.
Information
• The
• The
total mark for this paper is 90.
marks for each question are shown in brackets
– use this as a guide as to how much time to spend on each question.
Advice
•• Read each question carefully before you start to answer it.
Write your answers neatly and in good English.
•• Try to answer every question.
Check your answers if you have time at the end.
Pearson Edexcel International GCSE Human Biology (4HB1/01R)
Question Paper 01R And Mark Scheme 2026
, Answer ALL questions.
1 (a) The sentences are about the heart.
DO NOT WRITE IN THIS AREA
Complete the sentences by using words or numbers from the box.
(8)
80 100 120 atria body diastolic elastic tissue
lungs muscle systolic tendon vena cava ventricles
The heart consists of four chambers.
The two upper chambers are called . . . .... ... ... ... ... ... ... ... ... ... ... ... .. ... ... ... ... ... ... ... .
The left upper chamber receives blood from the ........................... whilst
the right upper chamber receives blood from the body through the
. . . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .
DO NOT WRITE IN THIS AREA
The two lower chambers are called . . .. ... ... ... .... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... . .
The left lower chamber pumps blood to the . . . ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .
This left lower chamber has a very thick wall made of . . ... .... .... .... .... .... .... .... ... .... .... .... .... .... .. .... . .
When the chamber contracts, it generates a pressure
known as the .......................... pressure.
The average value for this pressure is about ............................ mmHg.
DO NOT WRITE IN THIS AREA
2
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, (b) Cardiac output is the volume of blood pushed out of the heart in one minute.
Cardiac output is calculated using this formula.
DO NOT WRITE IN THIS AREA
cardiac output = heart rate × stroke volume
The stroke volume is the volume, in dm3, of blood pushed out during one
heartbeat. The heart rate is the number of beats per minute.
Calculate the stroke volume for a person with a heart rate of 68 beats per minute
and a cardiac output of 6.1 dm3.
Give your answer in cm3.
(3)
stroke volume = ........................... cm3
DO NOT WRITE IN THIS AREA
(Total for Question 1 = 11 marks)
DO NOT WRITE IN THIS AREA
3
■■■■ Turn over
Candidate surname Other names
Centre Number Candidate Number
Pearson Edexcel International GCSE
Afternoon (Time: 1 hour 45 minutes) Paper
reference 4HB1/01R
Human Biology 🟐 🟐
UNIT: 4HB1
PAPER: 01R
You must have: Total Marks
Ruler
Candidates may use a calculator
Instructions
•• Use black ink or ball-point pen.
If pencil is used for diagrams/sketches/graphs it must be dark (HB or B).
• Fill in the boxes at the top of this page with your name,
centre number and candidate number.
• Answer all questions.
• Answer the questions in the spaces provided
– there may be more space than you need.
• Show all the steps in any calculations and state the units.
Information
• The
• The
total mark for this paper is 90.
marks for each question are shown in brackets
– use this as a guide as to how much time to spend on each question.
Advice
•• Read each question carefully before you start to answer it.
Write your answers neatly and in good English.
•• Try to answer every question.
Check your answers if you have time at the end.
Pearson Edexcel International GCSE Human Biology (4HB1/01R)
Question Paper 01R And Mark Scheme 2026
, Answer ALL questions.
1 (a) The sentences are about the heart.
DO NOT WRITE IN THIS AREA
Complete the sentences by using words or numbers from the box.
(8)
80 100 120 atria body diastolic elastic tissue
lungs muscle systolic tendon vena cava ventricles
The heart consists of four chambers.
The two upper chambers are called . . . .... ... ... ... ... ... ... ... ... ... ... ... .. ... ... ... ... ... ... ... .
The left upper chamber receives blood from the ........................... whilst
the right upper chamber receives blood from the body through the
. . . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .. . .
DO NOT WRITE IN THIS AREA
The two lower chambers are called . . .. ... ... ... .... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... . .
The left lower chamber pumps blood to the . . . ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .
This left lower chamber has a very thick wall made of . . ... .... .... .... .... .... .... .... ... .... .... .... .... .... .. .... . .
When the chamber contracts, it generates a pressure
known as the .......................... pressure.
The average value for this pressure is about ............................ mmHg.
DO NOT WRITE IN THIS AREA
2
■■■■
, (b) Cardiac output is the volume of blood pushed out of the heart in one minute.
Cardiac output is calculated using this formula.
DO NOT WRITE IN THIS AREA
cardiac output = heart rate × stroke volume
The stroke volume is the volume, in dm3, of blood pushed out during one
heartbeat. The heart rate is the number of beats per minute.
Calculate the stroke volume for a person with a heart rate of 68 beats per minute
and a cardiac output of 6.1 dm3.
Give your answer in cm3.
(3)
stroke volume = ........................... cm3
DO NOT WRITE IN THIS AREA
(Total for Question 1 = 11 marks)
DO NOT WRITE IN THIS AREA
3
■■■■ Turn over
