Advanced Pathophysiology Final Exam – Comprehensive Advanced
Study Guide
Pathophysiology
and Practice Questions.pdf
Final Exam – Comprehensive Advanced
Study Guide
Pathophysiology
and Practice Questions.pdf
Final Exam – Comprehensive Study Guide and Practice Questions.pdf
Advanced Pathophysiology
Final Exam –
Comprehensive Study
Guide and Practice
Questions
Guidehttps://www.stuvia.com/dashboard!@_)#*)(@$)($@*($@)($@*_
Advanced Pathophysiology Final Exam – Comprehensive Advanced
Study Guide
Pathophysiology
and Practice Questions.pdf
Final Exam – Comprehensive Advanced
Study Guide
Pathophysiology
and Practice Questions.pdf
Final Exam – Comprehensive Study Guide and Practice Questions.pdf
,Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
Terms in this set (604)
Do women or men more often have multiple sclerosis? Women (2-3:1)
Which disease has the following risk factors: Multiple Sclerosis
-Epstein-barr virus (EBV)
-Live above the 37th parallel
-Caucasian
-Female
-Vitamin D deficiency: Decreased time between clinical
isolated syndrome (CIS) and 2nd exacerbation
-Smoking
What is the main pathophysiological theory for multiple It's an autoimmune/neurodegenerative disease:
sclerosis? -inflammation
-demyelination/remyelination
-permanent axonal damage
What are the Myelin forming cells of the CNS? Oligodendrocytes
What do T-Helper cell types 1 & 17 do? Pro-inflammatory
Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
,Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
What does T-Helper cell type 2 do? Anti-inflammatory
What is the pathophysiology of Multple Sclerosis? 1. Autoreactive T cells express Very Late Antegen-4 (VLA-4, aka α4-integrin) on
their cell surface and secrete Matrix Metalloproteinases (MMP).
2. VLA-4 binds to Vascular Cell Adhesion Molecule (VCAM) receptors on the
blood brain barrier (BBB) and MMP results in dysregulation of the BBB, allowing
cell entry into the CNS.
3. Once in the CNS, pro-inflammatory cytokines (TNF-α, INF-γ, and Osteopontin
[OP]) are secreted resulting in inflammation and further T cell entry into the CNS.
4. T cells in the CNS interact with microglia, astrocytes, and macrophages to
produce reactive oxygen species and nitric oxide causing CNS damage.
5. B cells acts as ACPs, enter the CNS, and produce myelin-specific antibodies
that form membrane attack complexes with complement causing cell lysis.
Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
, Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
Which disease presents in the following way: Multiple Sclerosis
**Visual changes, optic neuritis (Often the 1st
sign/symptom)
-Paresthesias
-Gait issues/falls
-Foot drop
-Dysdiadochokinesia
-Fatigue
-Weakness
-Impaired coordination
-Cognitive changes
MRI:
***Gadolinium enhanced lesions
LUMBAR PUNCTURE TEST:
-Increased IgG
-Increased Myelin basic protein (MBP)
-Increased CSF protein
Which cognitive test is most commonly used to diagnose Symbol Digit Modalities Test (SDMT)
MS?
Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
Study Guide
Pathophysiology
and Practice Questions.pdf
Final Exam – Comprehensive Advanced
Study Guide
Pathophysiology
and Practice Questions.pdf
Final Exam – Comprehensive Study Guide and Practice Questions.pdf
Advanced Pathophysiology
Final Exam –
Comprehensive Study
Guide and Practice
Questions
Guidehttps://www.stuvia.com/dashboard!@_)#*)(@$)($@*($@)($@*_
Advanced Pathophysiology Final Exam – Comprehensive Advanced
Study Guide
Pathophysiology
and Practice Questions.pdf
Final Exam – Comprehensive Advanced
Study Guide
Pathophysiology
and Practice Questions.pdf
Final Exam – Comprehensive Study Guide and Practice Questions.pdf
,Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
Terms in this set (604)
Do women or men more often have multiple sclerosis? Women (2-3:1)
Which disease has the following risk factors: Multiple Sclerosis
-Epstein-barr virus (EBV)
-Live above the 37th parallel
-Caucasian
-Female
-Vitamin D deficiency: Decreased time between clinical
isolated syndrome (CIS) and 2nd exacerbation
-Smoking
What is the main pathophysiological theory for multiple It's an autoimmune/neurodegenerative disease:
sclerosis? -inflammation
-demyelination/remyelination
-permanent axonal damage
What are the Myelin forming cells of the CNS? Oligodendrocytes
What do T-Helper cell types 1 & 17 do? Pro-inflammatory
Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
,Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
What does T-Helper cell type 2 do? Anti-inflammatory
What is the pathophysiology of Multple Sclerosis? 1. Autoreactive T cells express Very Late Antegen-4 (VLA-4, aka α4-integrin) on
their cell surface and secrete Matrix Metalloproteinases (MMP).
2. VLA-4 binds to Vascular Cell Adhesion Molecule (VCAM) receptors on the
blood brain barrier (BBB) and MMP results in dysregulation of the BBB, allowing
cell entry into the CNS.
3. Once in the CNS, pro-inflammatory cytokines (TNF-α, INF-γ, and Osteopontin
[OP]) are secreted resulting in inflammation and further T cell entry into the CNS.
4. T cells in the CNS interact with microglia, astrocytes, and macrophages to
produce reactive oxygen species and nitric oxide causing CNS damage.
5. B cells acts as ACPs, enter the CNS, and produce myelin-specific antibodies
that form membrane attack complexes with complement causing cell lysis.
Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
, Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
Which disease presents in the following way: Multiple Sclerosis
**Visual changes, optic neuritis (Often the 1st
sign/symptom)
-Paresthesias
-Gait issues/falls
-Foot drop
-Dysdiadochokinesia
-Fatigue
-Weakness
-Impaired coordination
-Cognitive changes
MRI:
***Gadolinium enhanced lesions
LUMBAR PUNCTURE TEST:
-Increased IgG
-Increased Myelin basic protein (MBP)
-Increased CSF protein
Which cognitive test is most commonly used to diagnose Symbol Digit Modalities Test (SDMT)
MS?
Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf Advanced Pathophysiology Final Exam.pdf
