BIO 351 Module 1
QUESTIONS AND VERIFIED
CORRECT ANSWER GRADED
A+ 100% GUARANTEED PASS
LATEST[2026-2027]
You grow mesenchymal cells in Dish A and epidermal cells in Dish B. If you take the liquid
medium only (containing no cells) from Dish A and place some of it into the liquid medium
covering the epidermal cells in Dish B, you notice that it causes the epidermal cells to round up
and thicken. What developmental concept does this example best describe? - CORRECT
ANSWER-Induction of epithelial cells by paracrine signaling from mesenchymal cells.
The normal morphogen gradient in a limb bud is shown in the diagram below on the left. The
panel on the right shows the levels of morphogen after a bead soaked with SHH is transplanted
into the rostral side of a limb bud. Which of the following (A-E) best describes the expected
pattern of digits? - CORRECT ANSWER-Not E
During eye development, a region of the developing brain grows outwards to be adjacent to the
surface ectoderm. These two tissues then differentiate into the retina and lens, respectively.
Placing a piece of aluminum foil between these two tissues blocks both of these differentiation
processes. However, placing a piece of permeable membrane allows both processes to proceed.
Based on these observations, what type of signaling is taking place? - CORRECT ANSWER-
Paracrine- inducer released from a distance
, The diagram below shows an example of juxtacrine signaling. Cell-cell contact is mediated
through the __________ ligand on the inducing cell and ___________receptor on the
responding cell in this pathway. - CORRECT ANSWER-Delta, Notcht
In the signaling diagram on the below, the ligand binds to a ________ . Fill in the blank. -
CORRECT ANSWER-Receptor tyrosine kinase
Wnts play an important role in promoting EMT in developing neural crest progenitors. What is
the receptor for secreted Wnts? - CORRECT ANSWER-Frizzled
Application of FGF8 coated beads induce limb mesenchymal cell proliferation. In contrast, FGF8
coated beads implanted on the epidermis of the back do not promote proliferation. This
experiment provides an excellent example of which of the following? - CORRECT ANSWER-
Competence
What would skin fibroblasts become if you induced expression of Oct4 (Pou5tf), Myc, Klf4, and
Sox2? - CORRECT ANSWER-induced pluripotent stem cells (iPSCs)
Signaling between endosteal osteoblasts and hematopoietic stem cells (HSCs) in the bone
marrow niche are necessary for which of the following? - CORRECT ANSWER-Maintenance of
HSC potency and proliferation
Which of the following best describes the most important properties of the Yamanaka factors
for iPSC generation? - CORRECT ANSWER-Pioneering transcription factors expressed in ES cells.
Organoids are considered mini-tissues in a 3D culture dish. They rely on an extracellular matrix
artificially supplied to support organoid formation and growth. Organoids can recapitulate many
or all of the cell types found within a specific tissue. For example, intestinal organoids contain
the diverse array of absorptive and secretory cells found within the intestine that are required
for intestine function. Given that organoids can regenerate differentiated cell types within the
tissue as well as self-renew to maintain the organoid upon multiple passages, what is the likely
cell-of-origin for an organoid to form? - CORRECT ANSWER-a stem cell
QUESTIONS AND VERIFIED
CORRECT ANSWER GRADED
A+ 100% GUARANTEED PASS
LATEST[2026-2027]
You grow mesenchymal cells in Dish A and epidermal cells in Dish B. If you take the liquid
medium only (containing no cells) from Dish A and place some of it into the liquid medium
covering the epidermal cells in Dish B, you notice that it causes the epidermal cells to round up
and thicken. What developmental concept does this example best describe? - CORRECT
ANSWER-Induction of epithelial cells by paracrine signaling from mesenchymal cells.
The normal morphogen gradient in a limb bud is shown in the diagram below on the left. The
panel on the right shows the levels of morphogen after a bead soaked with SHH is transplanted
into the rostral side of a limb bud. Which of the following (A-E) best describes the expected
pattern of digits? - CORRECT ANSWER-Not E
During eye development, a region of the developing brain grows outwards to be adjacent to the
surface ectoderm. These two tissues then differentiate into the retina and lens, respectively.
Placing a piece of aluminum foil between these two tissues blocks both of these differentiation
processes. However, placing a piece of permeable membrane allows both processes to proceed.
Based on these observations, what type of signaling is taking place? - CORRECT ANSWER-
Paracrine- inducer released from a distance
, The diagram below shows an example of juxtacrine signaling. Cell-cell contact is mediated
through the __________ ligand on the inducing cell and ___________receptor on the
responding cell in this pathway. - CORRECT ANSWER-Delta, Notcht
In the signaling diagram on the below, the ligand binds to a ________ . Fill in the blank. -
CORRECT ANSWER-Receptor tyrosine kinase
Wnts play an important role in promoting EMT in developing neural crest progenitors. What is
the receptor for secreted Wnts? - CORRECT ANSWER-Frizzled
Application of FGF8 coated beads induce limb mesenchymal cell proliferation. In contrast, FGF8
coated beads implanted on the epidermis of the back do not promote proliferation. This
experiment provides an excellent example of which of the following? - CORRECT ANSWER-
Competence
What would skin fibroblasts become if you induced expression of Oct4 (Pou5tf), Myc, Klf4, and
Sox2? - CORRECT ANSWER-induced pluripotent stem cells (iPSCs)
Signaling between endosteal osteoblasts and hematopoietic stem cells (HSCs) in the bone
marrow niche are necessary for which of the following? - CORRECT ANSWER-Maintenance of
HSC potency and proliferation
Which of the following best describes the most important properties of the Yamanaka factors
for iPSC generation? - CORRECT ANSWER-Pioneering transcription factors expressed in ES cells.
Organoids are considered mini-tissues in a 3D culture dish. They rely on an extracellular matrix
artificially supplied to support organoid formation and growth. Organoids can recapitulate many
or all of the cell types found within a specific tissue. For example, intestinal organoids contain
the diverse array of absorptive and secretory cells found within the intestine that are required
for intestine function. Given that organoids can regenerate differentiated cell types within the
tissue as well as self-renew to maintain the organoid upon multiple passages, what is the likely
cell-of-origin for an organoid to form? - CORRECT ANSWER-a stem cell
