N5334 Final Exam Study Guide & Practice Questions | Complete Review with Answers

N5334sFinal

Prescribingsbasicss-
sCORRECTsANSWER✔Prescribing sissregulatedsbysstatesBON




PropersRXs-
sCORRECTsANSWER✔Providerssnamesandsaddress,sTelephone



DEA
Ptsname/DOB/Addres
NamesofsDrug,sstrength,sSIG(directions)swithsindication/
Routesandsfrequency,sQuantitysandssignature.


DrugsSchedules:sMostsaddictivestosleasts-
sCORRECTsANSWER✔1:sHeroin,LSD,sMJ



2:shydrocodone,scocaine,sMethamphetamine,smethadone,soxycodone,sme
peridine,sfentanyl,sadderall,sritalin
3:scodeine,sketamine,stestosterone
4:sxanax,svalium,ssoma,sambient,stramadol
5:santidiarrheal,santitussives,slomotil,slyrica


Pharmicodyamicss-
sCORRECTsANSWER✔Theseffectssofsdrugsonsthesbody.sReceptorssaresl

argesmoleculessusuallysproteins,sthatsinteractsandsmediatesthesactionsofsdru
gs

,agonists-
sCORRECTsANSWER✔producesreceptorsstimulation sandsasconformatio

nalschangeseverystimestheysbind.sDosnotsneedsallsavailablesreceptorsstospro
ducesasmaximumsresponse


Partialsagonists-
sCORRECTsANSWER✔drugssthatshavespropertiessinsb/

wsthosesofsfullsagonistsandsantagonist.sTheysbindstosreceptorssbutswhensthe
ysoccupysthesreceptorssites,stheysstimulatesonlyssomesofsthesreceptors.


antagonists-
sCORRECTsANSWER✔drugsswithsaffinitysforsasreceptorsbutswithsnosintr

insicsactivity.sAffinitysallowssthesantagoniststosbindstosreceptors,sbutslackso
fsintrinsicsactivityspreventssthesboundsantagonistsfromscausingsreceptorsact
ivation.sThesblocksactionsofsdrugss(ex.sNarcan)


Bioavailabitys-sCORRECTsANSWER✔
%sofsadministeredsdosagesofsthesdrugsthatssurvivessthesfirstspasssthroughsth
esliversandsreachessthesbloodsstream


halfslifes-
sCORRECTsANSWER✔Timesrequiredsforsthesamountsofsasdrugsinsthesbo

dystosdeclinesbys50%,sdrugsswithsshortershalfslivessmustsbesadministersfreq
uently.s4.5-
5.5stimesstheshalfslifestosgetssteadysstatesandstosbeslimitedsfromsthesbody


whatsthesbodysdoesstosthesdrugs-
sCORRECTsANSWER✔absorption, sdistribution, smetabolism, sexcretion

,Distributions-
sCORRECTsANSWER✔movementsofsabsorbedsdrugsinsbodilysfluidssthr

oughoutsthesbodystostargetstissue.sPropertiessaffecting:slipid/
waterssolubility,sPHsaffectssionizationsofsdrug,sproteinsbinding,ssizesofsmol
ecules(smallersmoleculessaresmoresablestosdiffuse)


Tissue:sfat,sbone,sblood/
brainsbarriers(onlyslipidssolubleswillspass),splacentalsbarriers(manysdrugssca
nspass)


Proteinsbindings-
sCORRECTsANSWER✔unboundsdrugsissfreeswhichsissactive,scrossessme

mbrane.sLowsplasmasproteinssresultsinsmoresfreesdrug.sCompetition:swhens
2shighlysboundsdrugssaresgivensitsincreasesstheslevelsofsbothsdrugs


Metabolisms-
sCORRECTsANSWER✔takesplacesinsthesliversmostly.sChemicalschanges

ofsasdrugsstructuresto:s
Enhancesexcretion,sinactivatesthesdrug,sincreasestherapeuticsaction,sactives
asprodrugs(inactivesuntilsmetabolizedsinsthesbodysintosthesactivescompound
,sex:slevodopa),sincreasesorsdecreasestoxicity


CYP450s-
sCORRECTsANSWER✔enzymessconstitutessthesmostsimportantsofsthesp

hasesIsmetabolizingsenzymess(accountsforsabouts75%sofsdrugsmetabolismsi
nsthesliver)

, Phases2:sconjugationsreactionsoccursleadingstoslargesincreasessinshydrophil
icitysofsthessubstratessrenderingsthemsmoresreadilysexcretable


Substrates-
sCORRECTsANSWER✔ansagentsthatsissmetabolized sbysansenzymesintosa

smetabolite sandsproductsandseventually sexcreted




Inhibitorss-
sCORRECTsANSWER✔competeswithsothersdrugssforsasparticularsenzym

esaffectingsthesmetabolisms(decreased)sofsthessubstratesandsdecreasessthese
xcretionsofsthessubstratesandsincreasingsthescirculatingsdrug


inducers-
sCORRECTsANSWER✔competesswithsothersdrugssforsasparticularsenzy

mesaffectingsmetabolismsofsthessubstrates(increases)sdecreasingsthesefficac
ysofsthesdrug


excretions-
sCORRECTsANSWER✔renal:spassivesglomerularsfiltration,sactivestubul

arssecretion,stubularsreabsorption,sgistract,slung,ssweatsandssalivary,smamm
ary


genomicss-
sCORRECTsANSWER✔studysofsthescomplete ssetsofsgeneticsinformation s

presentsinsascell,sansorganism,sorsspecies