PCB 4233 EXAM 3 QUESTIONS WITH
CORRECT ANSWERS
In type III immune response, both TH17 and ILC3 cells secrete IL-17 to activate:
| | | | | | | | | | | | |
A.Macrophages
B.Dendritic cells |
C.Neutrophils
D.B cells |
E.Eosinophils - CORRECT ANSWER✔✔-C. Neutrophils | | | |
A few days after virus infection is cleared, the majority of virus-specific CD8 T cells
| | | | | | | | | | | | | |
start to die. The death of these T cells is caused by
| | | | | | | | | | | |
A. Fas-induced apoptosis
| |
B. NK cell-mediated cell lysis
| | | |
C. Recognition and phagocytosis by macrophages
| | | | |
D. Destruction by other CD8 T cells
| | | | | |
E. Lysis from viral infection - CORRECT ANSWER✔✔-A. Fas-induced apoptosis
| | | | | | | | |
Which of the following cytokinesis is important to maintain T cell memory?
| | | | | | | | | | |
,A. IL-22
|
B. IL-4
|
C. IL-1
|
D. IL-7
|
E. TNF-alpha - CORRECT ANSWER✔✔-D. IL-7
| | | | |
Effector memory T-cells (TEMs) can be distinguished from the central memory T-
| | | | | | | | | | |
cells (TCMs) by:
| |
A. IFN-γ secretion
| |
B. Their lifespans
| |
C. Expression level of CD3
| | | |
D. Expression level of CCR7 - CORRECT ANSWER✔✔-D.Expression level of CCR7
| | | | | | | | | |
The immune response is a dynamic process that initiates with an antigen-
| | | | | | | | | | |
independent response, which becomes more focused and powerful as it develops
| | | | | | | | | |
|antigen specificity. Once the adaptive immune system develops, a single type of
| | | | | | | | | | | |
cell or immunoglobulin is capable of eliminating any type of pathogen.
| | | | | | | | | |
A. True
|
B. False - CORRECT ANSWER✔✔-B. False
| | | | |
In response to an intracellular bacterial or viral infection, effector TH1 cells,
| | | | | | | | | | | |
macrophages, NK cells, and CD8 cytotoxic effector cells are all recruited to the
| | | | | | | | | | | | |
, site of infection. The coordinated recruitment of all of these cell types is
| | | | | | | | | | | | |
orchestrated by: |
A. The shared expression of chemokine receptors on these different cell types
| | | | | | | | | | |
B. The up-regulation of integrin ligands such as VLA-4 on the blood vessel
| | | | | | | | | | | | |
endothelial cells | |
C. The secretion of the inflammatory cytokine IFN-γ in the tissue
| | | | | | | | | |
D. The shared expression of S1PR1 on these cells, recruiting them out of
| | | | | | | | | | | | |
lymphoid tissues |
E. The action of TNF-α on the endothelial cells, leading to fluid leakage into the
| | | | | | | | | | | | | | |
tissue - CORRECT ANSWER✔✔-A. The shared expression of chemokine receptors
| | | | | | | | | |
on these different cell types
| | | |
It is well documented that antibody affinities for an immunizing antigen continue
| | | | | | | | | | | |
to increase upon successive rounds of immunization (i.e., secondary, tertiary,
| | | | | | | | | |
etc.). This is due to the fact that:
| | | | | | |
A. At each round of immunization, the expression of AID increases, leading to
| | | | | | | | | | | | |
higher rates of somatic hypermutation.
| | | |
B. At each round of immunization, germinal centers become larger and have
| | | | | | | | | | | |
increased numbers of B cells in them. | | | | | |
C. At each round of immunization, new naïve B cells are recruited into the
| | | | | | | | | | | | | |
response.
D. Memory B cells can re-enter germinal centers and undergo additional somatic
| | | | | | | | | | | |
hypermutation.
E. Memory B cells express higher levels of AID than naïve B cells, leading to
| | | | | | | | | | | | | | |
higher rates of somatic hypermutation. - CORRECT ANSWER✔✔-D. Memory B
| | | | | | | | | |
CORRECT ANSWERS
In type III immune response, both TH17 and ILC3 cells secrete IL-17 to activate:
| | | | | | | | | | | | |
A.Macrophages
B.Dendritic cells |
C.Neutrophils
D.B cells |
E.Eosinophils - CORRECT ANSWER✔✔-C. Neutrophils | | | |
A few days after virus infection is cleared, the majority of virus-specific CD8 T cells
| | | | | | | | | | | | | |
start to die. The death of these T cells is caused by
| | | | | | | | | | | |
A. Fas-induced apoptosis
| |
B. NK cell-mediated cell lysis
| | | |
C. Recognition and phagocytosis by macrophages
| | | | |
D. Destruction by other CD8 T cells
| | | | | |
E. Lysis from viral infection - CORRECT ANSWER✔✔-A. Fas-induced apoptosis
| | | | | | | | |
Which of the following cytokinesis is important to maintain T cell memory?
| | | | | | | | | | |
,A. IL-22
|
B. IL-4
|
C. IL-1
|
D. IL-7
|
E. TNF-alpha - CORRECT ANSWER✔✔-D. IL-7
| | | | |
Effector memory T-cells (TEMs) can be distinguished from the central memory T-
| | | | | | | | | | |
cells (TCMs) by:
| |
A. IFN-γ secretion
| |
B. Their lifespans
| |
C. Expression level of CD3
| | | |
D. Expression level of CCR7 - CORRECT ANSWER✔✔-D.Expression level of CCR7
| | | | | | | | | |
The immune response is a dynamic process that initiates with an antigen-
| | | | | | | | | | |
independent response, which becomes more focused and powerful as it develops
| | | | | | | | | |
|antigen specificity. Once the adaptive immune system develops, a single type of
| | | | | | | | | | | |
cell or immunoglobulin is capable of eliminating any type of pathogen.
| | | | | | | | | |
A. True
|
B. False - CORRECT ANSWER✔✔-B. False
| | | | |
In response to an intracellular bacterial or viral infection, effector TH1 cells,
| | | | | | | | | | | |
macrophages, NK cells, and CD8 cytotoxic effector cells are all recruited to the
| | | | | | | | | | | | |
, site of infection. The coordinated recruitment of all of these cell types is
| | | | | | | | | | | | |
orchestrated by: |
A. The shared expression of chemokine receptors on these different cell types
| | | | | | | | | | |
B. The up-regulation of integrin ligands such as VLA-4 on the blood vessel
| | | | | | | | | | | | |
endothelial cells | |
C. The secretion of the inflammatory cytokine IFN-γ in the tissue
| | | | | | | | | |
D. The shared expression of S1PR1 on these cells, recruiting them out of
| | | | | | | | | | | | |
lymphoid tissues |
E. The action of TNF-α on the endothelial cells, leading to fluid leakage into the
| | | | | | | | | | | | | | |
tissue - CORRECT ANSWER✔✔-A. The shared expression of chemokine receptors
| | | | | | | | | |
on these different cell types
| | | |
It is well documented that antibody affinities for an immunizing antigen continue
| | | | | | | | | | | |
to increase upon successive rounds of immunization (i.e., secondary, tertiary,
| | | | | | | | | |
etc.). This is due to the fact that:
| | | | | | |
A. At each round of immunization, the expression of AID increases, leading to
| | | | | | | | | | | | |
higher rates of somatic hypermutation.
| | | |
B. At each round of immunization, germinal centers become larger and have
| | | | | | | | | | | |
increased numbers of B cells in them. | | | | | |
C. At each round of immunization, new naïve B cells are recruited into the
| | | | | | | | | | | | | |
response.
D. Memory B cells can re-enter germinal centers and undergo additional somatic
| | | | | | | | | | | |
hypermutation.
E. Memory B cells express higher levels of AID than naïve B cells, leading to
| | | | | | | | | | | | | | |
higher rates of somatic hypermutation. - CORRECT ANSWER✔✔-D. Memory B
| | | | | | | | | |
