MSN 671 CERTIFICATION
EVALUATION BUNDLE 2026
QUESTIONS AND ACCURATE
ANSWERS GRADE A+
◉ What are the two main categories of antipsychotics? Answer: First
Generation Antipsychotics (FGA) and Second Generation
Antipsychotics (SGA).
◉ What is the mechanism of action for antipsychotics? Answer:
Dopamine D2 receptor blockade is central to antipsychotic efficacy.
◉ What percentage of D2 receptor occupancy is required for
antipsychotic efficacy? Answer: ~65% D2 receptor occupancy.
◉ What is the relationship between D2 receptor occupancy and
extrapyramidal symptoms (EPS)? Answer: Occupancy >80% correlates
with increased risk of EPS.
◉ What additional receptor activity do SGAs have compared to FGAs?
Answer: Serotonin 5-HT2A antagonism, which reduces EPS risk and
may improve negative and cognitive symptoms.
◉ What are the positive symptoms of schizophrenia? Answer:
Delusions, hallucinations, disorganized speech/behavior, and catatonia.
, ◉ What are the negative symptoms of schizophrenia? Answer: Blunted
affect, anhedonia, alogia, avolition, apathy, and emotional/social
withdrawal.
◉ What are the cognitive deficits associated with schizophrenia?
Answer: Impairments in memory, attention, language, and executive
function.
◉ What are the two classifications of First Generation Antipsychotics
(FGAs)? Answer: High potency and low potency.
◉ What are the risks associated with high potency FGAs? Answer:
Higher EPS risk and weaker anticholinergic effects.
◉ What are the advantages of First Generation Antipsychotics? Answer:
Injectable and depot formulations, and low cost.
◉ What are the disadvantages of First Generation Antipsychotics?
Answer: High risk of EPS and cardiac risks.
◉ What is the first atypical antipsychotic? Answer: Clozapine.
◉ What are the advantages of Second Generation Antipsychotics
(SGAs)? Answer: Lower EPS risk and availability of depot
formulations.
EVALUATION BUNDLE 2026
QUESTIONS AND ACCURATE
ANSWERS GRADE A+
◉ What are the two main categories of antipsychotics? Answer: First
Generation Antipsychotics (FGA) and Second Generation
Antipsychotics (SGA).
◉ What is the mechanism of action for antipsychotics? Answer:
Dopamine D2 receptor blockade is central to antipsychotic efficacy.
◉ What percentage of D2 receptor occupancy is required for
antipsychotic efficacy? Answer: ~65% D2 receptor occupancy.
◉ What is the relationship between D2 receptor occupancy and
extrapyramidal symptoms (EPS)? Answer: Occupancy >80% correlates
with increased risk of EPS.
◉ What additional receptor activity do SGAs have compared to FGAs?
Answer: Serotonin 5-HT2A antagonism, which reduces EPS risk and
may improve negative and cognitive symptoms.
◉ What are the positive symptoms of schizophrenia? Answer:
Delusions, hallucinations, disorganized speech/behavior, and catatonia.
, ◉ What are the negative symptoms of schizophrenia? Answer: Blunted
affect, anhedonia, alogia, avolition, apathy, and emotional/social
withdrawal.
◉ What are the cognitive deficits associated with schizophrenia?
Answer: Impairments in memory, attention, language, and executive
function.
◉ What are the two classifications of First Generation Antipsychotics
(FGAs)? Answer: High potency and low potency.
◉ What are the risks associated with high potency FGAs? Answer:
Higher EPS risk and weaker anticholinergic effects.
◉ What are the advantages of First Generation Antipsychotics? Answer:
Injectable and depot formulations, and low cost.
◉ What are the disadvantages of First Generation Antipsychotics?
Answer: High risk of EPS and cardiac risks.
◉ What is the first atypical antipsychotic? Answer: Clozapine.
◉ What are the advantages of Second Generation Antipsychotics
(SGAs)? Answer: Lower EPS risk and availability of depot
formulations.
