TEST BANK
PATHOPHYSIOLOGY
The Biologic Basis For Disease In
Adults And Children
8TH EDITION BY KATHRYN L.
MCCANCE
,McCance: vsPathophysiology: vsThe vsBiologic vsBasis vsfor vsDisease vsin vsAdults vsand vsChildren vs(8th vsEdition)
vsTEST vsBANK
CONTENTS:
Chapter vs01: vsCellular vsBiology
Chapter vs02: vsAltered vsCellular vsand vsTissue vsBiology: vsEnvironmental vsAgents
Chapter vs03: vsThe vsCellular vsEnvironment: vsFluids vsand vsElectrolytes, vsAcids vsand vsBases
Chapter vs04: vsGenes vsand vsGenetic vsDiseases
Chapter vs05: vsGenes, vsEnvironment-Lifestyle, vsand vsCommon vsDiseases
Chapter vs06: vsEpigenetics vsand vsDisease
Chapter vs07: vsInnate vsImmunity: vsInflammation vsand vsWound vsHealing
Chapter vs08: vsAdaptive vsImmunity
Chapter vs09: vsAlterations vsin vsImmunity vsand vsInflammation
Chapter vs10: vsInfection
Chapter vs11: vsStress vsand vsDisease
Chapter vs12: vsCancer vsBiology
Chapter vs13: vsCancer vsEpidemiology
Chapter vs14: vsCancer vsin vsChildren
Chapter vs15: vsStructure vsand vsFunction vsof vsthe vsNeurologic vsSystem
Chapter vs16: vsPain, vsTemperature vsRegulation, vsSleep, vsand vsSensory vsFunction
Chapter vs17: vsAlterations vsin vsCognitive vsSystems, vsCerebral vsHemodynamics, vsand vsMotor vsFunction
Chapter vs18: vsDisorders vsof vsthe vsCentral vsand vsPeripheral vsNervous vsSystems vsand vsthe vsNeuromuscular vsJunction
Chapter vs19: vsNeurobiology vsof vsSchizophrenia, vsMood vsDisorders, vsand vsAnxiety vsDisorders
Chapter vs20: vsAlterations vsof vsNeurologic vsFunction vsin vsChildren
Chapter vs21: vsMechanisms vsof vsHormonal vsRegulation
Chapter vs22: vsAlterations vsof vsHormonal vs Regulation
Chapter vs23: vsObesity vsand vsDisorders vsof vsNutrition
Chapter vs24: vsStructure vsand vsFunction vsof vsthe vsReproductive vsSystems
Chapter vs25: vsAlterations vsof vsthe vsFemale vsReproductive vsSystem
Chapter vs26: vsAlterations vsof vsthe vs Male vsReproductive vsSystem
Chapter vs27: vsSexually vsTransmitted vs Infections
Chapter vs28: vsStructure vsand vsFunction vsof vsthe vsHematologic vsSystem
Chapter vs29: vsAlterations vsof vsErythrocytes, vsPlatelets, vsand vsHemostatic vsFunction
Chapter vs30: vsAlterations vsof vsLeukocyte vsand vsLymphoid vsFunction
Chapter vs31: vsAlterations vsof vsHematologic vsFunction vsin vsChildren
Chapter vs32: vsStructure vsand vsFunction vsof vsthe vsCardiovascular vsand vsLymphatic vsSystems
Chapter vs33: vsAlterations vsof vsCardiovascular vsFunction
Chapter vs34: vsAlterations vsof vsCardiovascular vsFunction vsin vsChildren
Chapter vs35: vsStructure vsand vsFunction vsof vsthe vsPulmonary vsSystem
Chapter vs36: vsAlterations vsof vsPulmonary vsFunction
Chapter vs37: vsAlterations vsof vsPulmonary vsFunction vsin vsChildren
Chapter vs38: vsStructure vsand vsFunction vsof vsthe vsRenal vsand vsUrologic vsSystems
Chapter vs39: vsAlterations vsof vsRenal vsand vsUrinary vsTract vsFunction
Chapter vs40: vsAlterations vsof vsRenal vsand vsUrinary vsTract vsFunction vsin vsChildren
Chapter vs41: vsStructure vsand vsFunction vsof vsthe vsDigestive vsSystem
Chapter vs42: vsAlterations vsof vsDigestive vsFunction
Chapter vs43: vsAlterations vsof vsDigestive vsFunction vsin vsChildren
Chapter vs44: vsStructure vsand vsFunction vsof vsthe vsMusculoskeletal vsSystem
Chapter vs45: vsAlterations vsof vsMusculoskeletal vsFunction
Chapter vs46: vsAlterations vsof vsMusculoskeletal vsFunction vsin vsChildren
Chapter vs47: vsStructure, vsFunction, vsand vsDisorders vsof vsthe vsIntegument
Chapter vs48: vsAlterations vsof vsthe vs Integument vsin vsChildren
Chapter vs49: vsShock, vsMultiple vsOrgan vsDysfunction vsSyndrome, vsand vsBurns vsin vsAdults
Chapter vs50: vsShock, vsMultiple vsOrgan vsDysfunction vsSyndrome, vsand vsBurns vsin vsChildren
, (8thv s Children
McCance: v s Pathophysiology: v s The v s Biologic v s Basis v s for v s Disease v s in v s Adults v s and
Edition) v s TEST
vsB
Part vs1: vsCENTRAL vsCONCEPTS vsOF vsPATHOPHYSIOLOGY: vsCELLS vsAND
vsTISSUES vsUnit vsI: vsTHE vsCELL
CHAPTER vs01: vsCELLULAR vsBIOLOGY
MULTIPLE vsCHOICE
1. Which vsstatement vsbest vsdescribes vsthe vscellular vsfunction vsof vsmetabolic vsabsorption?
a. Cells vscan vsproduce vsproteins.
b. Cells vscan vssecrete vsdigestive
vsenzymes.
c. Cells vscan vstake vsin vsand vsuse
vsnutrients.
d. Cells vscan vssynthesize vsfats.
ANS: vs C
In vsmetabolic vsabsorption, vsall vscells vstake vsin vsand vsuse vsnutrients vsand vsother vssubstances vsfrom
vstheir vssurroundings. vsThe vsremaining vsoptions vsare vsnot vsinclusive vsin vstheir vsdescriptions vsof
vscellular vsmetabolic vsabsorption.
PTS: vs vs 1 DIF: Cognitive vsLevel: vsRemembering
2. Where vs is v s most vs of v s a v s cell’s vs genetic v s information, v s including v s RNA v s and vs DNA, v s contained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: v s C
The v s nucleus v s contains v s the v s nucleolus, v s a v s small v s dense v s structure v s composed v s largely
vsof v s RNA, v s mos vst v s of v s the v s cellular v s DNA, v s and v s the v s DNA-
binding v s proteins, v s such v s as v s the v s histones, v s which v s regulate v s its v s activity. v s The
v s mitochondria v s are v s res vsponsible v s for v s cellular v s respiration v s and v s energy v s production.
Ribosomes’ vschief vsfunction v s is vsto vsprovide vssites vsfor vscellular vsprotein v s synthesis.
v s Lysosomes v s functi vson v s as v s the v s intracellular v s digestive v s system.
PTS: 1 DIF: Cognitive v s Level: v s Remembering
3. Which v s component v s of vsthe v s cell v s produces v s hydrogen v s peroxide v s (H2O2) v s by vsusing
vs oxygen v s to v s re vsmove vs hydrogen vs atoms vs from vs specific v s substrates vs in v s an
v s oxidative v s reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: v s B
, (8thv s Children
McCance: v s Pathophysiology: v s The v s Biologic v s Basis v s for v s Disease v s in v s Adults v s and
Edition) v s TEST
vsB
Peroxisomes v s are v s so v s named v s because v s they v s usually v s contain v s enzymes v s that v s use
v s oxygen v s to v s remo vsve v s hydrogen v s atoms vsfrom v s specific vssubstrates vsin v s an vsoxidative
vsreaction v s that vsproduces v s H2O2, vswh vsich vsis vsa vspowerful vsoxidant vsand vspotentially
vsdestructive vsif vsit vsaccumulates vsor vsescapes vsfrom vspero vsxisomes.
Ribosomes v s are v s RNA-
protein v s complexes v s (nucleoproteins) v s that v s are v s synthesized v s in v s the v s nucleolus v s and
v s secreted v s into v s t vshe vscytoplasm vsthrough vspores vsin vsthe vsnuclear vsenvelope vscalled vsnuclear
vspore vscomplexes. vsLysoso v s mes vsare vssaclike vsstructures vsthat vsoriginate vsfrom vsthe vsGolgi
vscomplex vsand vscontain vsmore vsthan vs40 vsdigestive v s enzymes v s called v s hydrolases, v s which
v s catalyze v s bonds v s in v s proteins, v s lipids, v s nucleic v s acids
, vsand vscarbohydrates. vsAn vsendosome vsis vsa vsvesical vsthat vshas vsbeen vspinched vsoff vsfrom vsthe
vscellular vsmembrane.
PTS: v s v s v s 1 DIF: v s v s Cognitive v s Level: v s Remembering
4. Which v s cell v s component vs is v s capable v s of v s cellular v s autodigestion v s when v s it v s is v s released vs during
vscell v s injury?
a. Ribosome
b. Golgi v s complex
c. Smooth vsendoplasmic
vsreticulu vsm
d. Lysosomes
ANS: v s D
The v s lysosomal v s membrane v s acts v s as v s a v s protective v s shield v s between v s the v s powerful
v s digestive v s enzym vses vswithin vsthe vslysosome vsand vsthe vscytoplasm, vspreventing vstheir vsleakage
vsinto vsthe vscytoplasmic vsm v s atrix. v s Disruption v s of v s the v s membrane v s by v s various
v s treatments v s or v s cellular v s injury v s leads v s to v s a v s releas vse vsof vsthe vslysosomal vsenzymes,
vswhich vscan vsthen vsreact vswith vstheir vsspecific vssubstrates, vscausing vsce v s llular v s self-
digestion. v s The v s chief v s function v s of v s a v s ribosome v s is v s to v s provide v s sites v s for v s cellular vs protein
v s synthesis
. v s The v s Golgi v s complex v s is v s a v s network v s of v s flattened, v s smooth v s vesicles v s and
v s membranes v s often v s locate vsd vsnear vsthe vscell vsnucleus. vsThe vssmooth vsendoplasmic vsreticulum
vsis vsinvolved vsin vssteroid vshormone vsproduction v s and v s removing v s toxic v s substances v s from
v s the v s cell.
PTS: v s v s v s 1 DIF: v s v s Cognitive v s Level: v s Remembering
5. Which v s cAMP-mediated v s response v s is v s related vs to v s antidiuretic v s hormone?
a. Increased vsheart vsrate vsand v s force vsof
vs contracti vson
b. Secretion v s of v s cortisol
c. Increased v s retention v s of v s water
d. Breakdown v s of v s fat
ANS: v s C
Antidiuretic vshormone vsleads vsto vsincreased vsretention vsof vswater vsin vsthe vsbody. vsEpinephrine
vscauses vsincreases v s in v s heart v s rate v s and v s force v s of v s contraction. v s Increased v s cortisol
v s secretion v s is v s due v s to v s ACT
H. v s Breakdown v s of v s fat v s is v s due v s to v s glucagon.
PTS: v s v s v s 1 DIF: v s v s Cognitive v s Level: v s Remembering
6. During v s which vs phase v s of v s the v s cell vs cycle v s is vs DNA v s synthesized?
PATHOPHYSIOLOGY
The Biologic Basis For Disease In
Adults And Children
8TH EDITION BY KATHRYN L.
MCCANCE
,McCance: vsPathophysiology: vsThe vsBiologic vsBasis vsfor vsDisease vsin vsAdults vsand vsChildren vs(8th vsEdition)
vsTEST vsBANK
CONTENTS:
Chapter vs01: vsCellular vsBiology
Chapter vs02: vsAltered vsCellular vsand vsTissue vsBiology: vsEnvironmental vsAgents
Chapter vs03: vsThe vsCellular vsEnvironment: vsFluids vsand vsElectrolytes, vsAcids vsand vsBases
Chapter vs04: vsGenes vsand vsGenetic vsDiseases
Chapter vs05: vsGenes, vsEnvironment-Lifestyle, vsand vsCommon vsDiseases
Chapter vs06: vsEpigenetics vsand vsDisease
Chapter vs07: vsInnate vsImmunity: vsInflammation vsand vsWound vsHealing
Chapter vs08: vsAdaptive vsImmunity
Chapter vs09: vsAlterations vsin vsImmunity vsand vsInflammation
Chapter vs10: vsInfection
Chapter vs11: vsStress vsand vsDisease
Chapter vs12: vsCancer vsBiology
Chapter vs13: vsCancer vsEpidemiology
Chapter vs14: vsCancer vsin vsChildren
Chapter vs15: vsStructure vsand vsFunction vsof vsthe vsNeurologic vsSystem
Chapter vs16: vsPain, vsTemperature vsRegulation, vsSleep, vsand vsSensory vsFunction
Chapter vs17: vsAlterations vsin vsCognitive vsSystems, vsCerebral vsHemodynamics, vsand vsMotor vsFunction
Chapter vs18: vsDisorders vsof vsthe vsCentral vsand vsPeripheral vsNervous vsSystems vsand vsthe vsNeuromuscular vsJunction
Chapter vs19: vsNeurobiology vsof vsSchizophrenia, vsMood vsDisorders, vsand vsAnxiety vsDisorders
Chapter vs20: vsAlterations vsof vsNeurologic vsFunction vsin vsChildren
Chapter vs21: vsMechanisms vsof vsHormonal vsRegulation
Chapter vs22: vsAlterations vsof vsHormonal vs Regulation
Chapter vs23: vsObesity vsand vsDisorders vsof vsNutrition
Chapter vs24: vsStructure vsand vsFunction vsof vsthe vsReproductive vsSystems
Chapter vs25: vsAlterations vsof vsthe vsFemale vsReproductive vsSystem
Chapter vs26: vsAlterations vsof vsthe vs Male vsReproductive vsSystem
Chapter vs27: vsSexually vsTransmitted vs Infections
Chapter vs28: vsStructure vsand vsFunction vsof vsthe vsHematologic vsSystem
Chapter vs29: vsAlterations vsof vsErythrocytes, vsPlatelets, vsand vsHemostatic vsFunction
Chapter vs30: vsAlterations vsof vsLeukocyte vsand vsLymphoid vsFunction
Chapter vs31: vsAlterations vsof vsHematologic vsFunction vsin vsChildren
Chapter vs32: vsStructure vsand vsFunction vsof vsthe vsCardiovascular vsand vsLymphatic vsSystems
Chapter vs33: vsAlterations vsof vsCardiovascular vsFunction
Chapter vs34: vsAlterations vsof vsCardiovascular vsFunction vsin vsChildren
Chapter vs35: vsStructure vsand vsFunction vsof vsthe vsPulmonary vsSystem
Chapter vs36: vsAlterations vsof vsPulmonary vsFunction
Chapter vs37: vsAlterations vsof vsPulmonary vsFunction vsin vsChildren
Chapter vs38: vsStructure vsand vsFunction vsof vsthe vsRenal vsand vsUrologic vsSystems
Chapter vs39: vsAlterations vsof vsRenal vsand vsUrinary vsTract vsFunction
Chapter vs40: vsAlterations vsof vsRenal vsand vsUrinary vsTract vsFunction vsin vsChildren
Chapter vs41: vsStructure vsand vsFunction vsof vsthe vsDigestive vsSystem
Chapter vs42: vsAlterations vsof vsDigestive vsFunction
Chapter vs43: vsAlterations vsof vsDigestive vsFunction vsin vsChildren
Chapter vs44: vsStructure vsand vsFunction vsof vsthe vsMusculoskeletal vsSystem
Chapter vs45: vsAlterations vsof vsMusculoskeletal vsFunction
Chapter vs46: vsAlterations vsof vsMusculoskeletal vsFunction vsin vsChildren
Chapter vs47: vsStructure, vsFunction, vsand vsDisorders vsof vsthe vsIntegument
Chapter vs48: vsAlterations vsof vsthe vs Integument vsin vsChildren
Chapter vs49: vsShock, vsMultiple vsOrgan vsDysfunction vsSyndrome, vsand vsBurns vsin vsAdults
Chapter vs50: vsShock, vsMultiple vsOrgan vsDysfunction vsSyndrome, vsand vsBurns vsin vsChildren
, (8thv s Children
McCance: v s Pathophysiology: v s The v s Biologic v s Basis v s for v s Disease v s in v s Adults v s and
Edition) v s TEST
vsB
Part vs1: vsCENTRAL vsCONCEPTS vsOF vsPATHOPHYSIOLOGY: vsCELLS vsAND
vsTISSUES vsUnit vsI: vsTHE vsCELL
CHAPTER vs01: vsCELLULAR vsBIOLOGY
MULTIPLE vsCHOICE
1. Which vsstatement vsbest vsdescribes vsthe vscellular vsfunction vsof vsmetabolic vsabsorption?
a. Cells vscan vsproduce vsproteins.
b. Cells vscan vssecrete vsdigestive
vsenzymes.
c. Cells vscan vstake vsin vsand vsuse
vsnutrients.
d. Cells vscan vssynthesize vsfats.
ANS: vs C
In vsmetabolic vsabsorption, vsall vscells vstake vsin vsand vsuse vsnutrients vsand vsother vssubstances vsfrom
vstheir vssurroundings. vsThe vsremaining vsoptions vsare vsnot vsinclusive vsin vstheir vsdescriptions vsof
vscellular vsmetabolic vsabsorption.
PTS: vs vs 1 DIF: Cognitive vsLevel: vsRemembering
2. Where vs is v s most vs of v s a v s cell’s vs genetic v s information, v s including v s RNA v s and vs DNA, v s contained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: v s C
The v s nucleus v s contains v s the v s nucleolus, v s a v s small v s dense v s structure v s composed v s largely
vsof v s RNA, v s mos vst v s of v s the v s cellular v s DNA, v s and v s the v s DNA-
binding v s proteins, v s such v s as v s the v s histones, v s which v s regulate v s its v s activity. v s The
v s mitochondria v s are v s res vsponsible v s for v s cellular v s respiration v s and v s energy v s production.
Ribosomes’ vschief vsfunction v s is vsto vsprovide vssites vsfor vscellular vsprotein v s synthesis.
v s Lysosomes v s functi vson v s as v s the v s intracellular v s digestive v s system.
PTS: 1 DIF: Cognitive v s Level: v s Remembering
3. Which v s component v s of vsthe v s cell v s produces v s hydrogen v s peroxide v s (H2O2) v s by vsusing
vs oxygen v s to v s re vsmove vs hydrogen vs atoms vs from vs specific v s substrates vs in v s an
v s oxidative v s reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: v s B
, (8thv s Children
McCance: v s Pathophysiology: v s The v s Biologic v s Basis v s for v s Disease v s in v s Adults v s and
Edition) v s TEST
vsB
Peroxisomes v s are v s so v s named v s because v s they v s usually v s contain v s enzymes v s that v s use
v s oxygen v s to v s remo vsve v s hydrogen v s atoms vsfrom v s specific vssubstrates vsin v s an vsoxidative
vsreaction v s that vsproduces v s H2O2, vswh vsich vsis vsa vspowerful vsoxidant vsand vspotentially
vsdestructive vsif vsit vsaccumulates vsor vsescapes vsfrom vspero vsxisomes.
Ribosomes v s are v s RNA-
protein v s complexes v s (nucleoproteins) v s that v s are v s synthesized v s in v s the v s nucleolus v s and
v s secreted v s into v s t vshe vscytoplasm vsthrough vspores vsin vsthe vsnuclear vsenvelope vscalled vsnuclear
vspore vscomplexes. vsLysoso v s mes vsare vssaclike vsstructures vsthat vsoriginate vsfrom vsthe vsGolgi
vscomplex vsand vscontain vsmore vsthan vs40 vsdigestive v s enzymes v s called v s hydrolases, v s which
v s catalyze v s bonds v s in v s proteins, v s lipids, v s nucleic v s acids
, vsand vscarbohydrates. vsAn vsendosome vsis vsa vsvesical vsthat vshas vsbeen vspinched vsoff vsfrom vsthe
vscellular vsmembrane.
PTS: v s v s v s 1 DIF: v s v s Cognitive v s Level: v s Remembering
4. Which v s cell v s component vs is v s capable v s of v s cellular v s autodigestion v s when v s it v s is v s released vs during
vscell v s injury?
a. Ribosome
b. Golgi v s complex
c. Smooth vsendoplasmic
vsreticulu vsm
d. Lysosomes
ANS: v s D
The v s lysosomal v s membrane v s acts v s as v s a v s protective v s shield v s between v s the v s powerful
v s digestive v s enzym vses vswithin vsthe vslysosome vsand vsthe vscytoplasm, vspreventing vstheir vsleakage
vsinto vsthe vscytoplasmic vsm v s atrix. v s Disruption v s of v s the v s membrane v s by v s various
v s treatments v s or v s cellular v s injury v s leads v s to v s a v s releas vse vsof vsthe vslysosomal vsenzymes,
vswhich vscan vsthen vsreact vswith vstheir vsspecific vssubstrates, vscausing vsce v s llular v s self-
digestion. v s The v s chief v s function v s of v s a v s ribosome v s is v s to v s provide v s sites v s for v s cellular vs protein
v s synthesis
. v s The v s Golgi v s complex v s is v s a v s network v s of v s flattened, v s smooth v s vesicles v s and
v s membranes v s often v s locate vsd vsnear vsthe vscell vsnucleus. vsThe vssmooth vsendoplasmic vsreticulum
vsis vsinvolved vsin vssteroid vshormone vsproduction v s and v s removing v s toxic v s substances v s from
v s the v s cell.
PTS: v s v s v s 1 DIF: v s v s Cognitive v s Level: v s Remembering
5. Which v s cAMP-mediated v s response v s is v s related vs to v s antidiuretic v s hormone?
a. Increased vsheart vsrate vsand v s force vsof
vs contracti vson
b. Secretion v s of v s cortisol
c. Increased v s retention v s of v s water
d. Breakdown v s of v s fat
ANS: v s C
Antidiuretic vshormone vsleads vsto vsincreased vsretention vsof vswater vsin vsthe vsbody. vsEpinephrine
vscauses vsincreases v s in v s heart v s rate v s and v s force v s of v s contraction. v s Increased v s cortisol
v s secretion v s is v s due v s to v s ACT
H. v s Breakdown v s of v s fat v s is v s due v s to v s glucagon.
PTS: v s v s v s 1 DIF: v s v s Cognitive v s Level: v s Remembering
6. During v s which vs phase v s of v s the v s cell vs cycle v s is vs DNA v s synthesized?
