2026|All 432 Questions With Correct
Accurate Answers With Rationales|
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1. A 48-year-old female psychologist presents to clinic with concerns about
her breast cancer risk after an age-matched cousin was recently
diagnosed with this disease. This cousin is the third family member on
her father's side in as many years to be diagnosed with breast cancer,
including the patient's own father, who had surgery and subsequent
treatment 3 years ago for breast cancer. The patient has little other
knowledge of her family history, only that her grandparents
independently arrived from Eastern Europe near the end of World War II
and were among very few members of their family that survived the war.
The patient has read about testing for the breast cancer genes [BRCA1
and BRCA2) and desires further information about whether this would be
appropriate for her. Which of the following is true about this patient's
indications for BRCA testing - ANSWER✔️✔️-This patient carries
several risk factors that together justify BRCA testing
2. A 44-year-old female mathematician presents to clinic with a complaint
of a mass in the right breast. Her partner noticed this mass 2 days ago,
and the patient feels guilty because she has only had one mammogram
and does not engage in breast self-examination (BSE) on any regular
basis. She has no family history of breast cancer, and her prior
mammogram was ordered as a routine screening test at age 43 years after
a brief discussion with her primary care provider. After a thorough
investigation reveals a benign cyst, what advice should be given to this
patient about screening for breast cancer in her age group? -
ANSWER✔️✔️-This patient was in compliance with the U.S.
Preventive Services Task Force (USPSTF) recommendations for her age
group and risk factors prior to her current complaint.
,rational: This patient is in compliance with USPSTF for her age group and
risk factors
Recommendations: < 50 years old - discuss risks and benefits with their
provider & make their own plan
3. A 42-year-old female website developer presents for an annual preventive
examination with questions about breast cancer screening. She is
concerned about the radiation exposure associated with mammography
and is interested in magnetic resonance imaging (MRI) as a possible
alternative for routine screening. She is otherwise healthy with no family
history of breast, ovarian, or colon cancer. Which of the following is true
about MRI as a screening modality for breast cancer in the general
population? - ANSWER✔️✔️-Sensitivity of screening for breast cancer
increases with breast MRI at the expense of specificity.
Rational: increased sensitivity (in this case, higher resolution imaging to
pick up subtler disease) is often traded for reduced specificity (in the form of
discovering many small items of no pathological significance).
Very sensitive tests pick up false positives
Very specific tests often rule out disease effectively by missing many actual
cases
4. A 35-year-old G0P0 woman presents to clinic with a complaint of
bilateral nipple discharge. This discharge started several weeks ago and
has occurred at irregular intervals since that time. She does not complain
of local tenderness, redness, fever, or any other systemic symptoms aside
from slightly irregular periods over the last few months. On examination,
she is able to express a small amount of discharge, which is sent to the
laboratory and found to be consistent with breast milk but without any
signs of blood or pus. Screening laboratories are also sent, which reveal a
normal blood count,
metabolic panel, thyroid-stimulating hormone, and human chorionic
gonadotropin (HCG) level. Further laboratories are still pending. Which of
the following is the most likely diagnosis - ANSWER✔️✔️-Prolactinoma
Rational: Prolactinoma: pituitary tumors that secrete prolactin, which causes
the production of breast milk and can suppress menstruation
,5. A 22-year-old G0P0 undergraduate student presents to clinic after finding
a breast mass on breast self-examination (BSE) at home. The mass is
nontender without skin changes, erythema, or overlying swelling. She has
heard that most breast cancers are found by patients themselves, and she
is very concerned that she may have breast cancer. Which of the
following is true about BSE and self-detection of breast cancer? -
ANSWER✔️✔️-This patient is more likely to find a fibroadenoma than
a cancer on self-examination
Rational: Palpable fibroadenomas are more likely to be found in the age
range: 15-25
6. A 68-year-old former paleontologist presents to clinic with concerns
about her breast cancer risk. Her mother developed the disease in her 50s
and died from it in her 60s. A younger cousin developed the disease a few
years ago before the age of 50 years, but this individual was not tested for
the BRCA1 and BRCA2 genes. In addition, the patient suffered from
lymphoma in her 20s and had radiation to the chest. She did take
hormone replacement therapy for a few years before data emerged that
this may contribute to breast cancer risk. She has had several abnormal
mammograms in her 50s for persistently dense breasts with subtle
findings, but follow-up biopsies never showed
any malignant pathology. Which of the following is true regarding magnetic
resonance imaging (MRI) screening of this patient? - ANSWER✔️✔️-
Regardless of recommendations, the high sensitivity of breast MRI comes at
the expense of markedly decreased specificity (i.e., the ability to rule out
disease in healthy breasts)
rational: This patient presents with an extraordinary risk profile - Strong
family history of breast cancer (suggestive of BRCA linkage to disease but
without clear diagnosis)
7. A 66-year-old female museum curator presents for a routine annual
examination. On examination, a notably enlarged supraclavicular lymph
node is appreciated on the right side. The lymph node is nontender and
feels firm and rubbery. She denies any localized or systemic symptoms
such as breast lumps, fevers, or night sweats. She has been taking
conjugated estrogen tablets for 9 years since menopause, though she has
, not taken progestin compounds since she had a hysterectomy for heavy
bleeding at age 45 years.
Which of the following is true about this presentation of lymphadenopathy?
- ANSWER✔️✔️-Metastatic breast cancer cells may spread directly into
the infraclavicular and then supraclavicular nodes without first causing
notable changes in the axillary nodes.
Rational: - Supraclavicular LNs are uniformly considered malignant until
proven otherwise- The DDx for these malignancies is wide but includes
cancers of the breasts, lung, head, and neck, esophagus, pancreas, etc.
8. A 24-year-old graphic designer presents to clinic with a concern for a
breast mass. A rubbery, mobile, nontender mass is palpated in the right
breast as described by the patient, which is consistent with a
fibroadenoma. In describing the location of the mass, the examiner notes
that it is 3 cm proximal to and 3 cm to the left of the nipple. Which of the
following would be the most appropriate way to report this finding? -
ANSWER✔️✔️-Rubbery, mobile, nontender mass located in right
breast, in the 10:30 position from the nipple"
9. A 54-year-old female dietician presents for a routine annual examination.
On review of systems, she reports that she has had many breast findings
over several years, including one biopsy with normal pathology. She feels
that her breasts have become far less lumpy since she underwent
menopause 3 years ago. Which of the following is true regarding changes
in the breasts with menopause? - ANSWER✔️✔️-Glandular tissue of
the breast atrophies with menopause, primarily due to decrease in the
number of lobules.
Rational: - The consequent decrease in breast density makes mammograms
ever more useful during the age when breast cancer incidence starts to rise
markedly
10. An overweight 26-year-old public servant presents to the Emergency
Department with 12 hours of intense abdominal pain, light-headedness,
and a fainting episode that finally prompted her to seek medical attention.
She has a strong family history of gallstones and is concerned about this
possibility. She has not had any vomiting or diarrhea. She had a normal
bowel movement this morning. Her β-human chorionic gonadotropin (β-