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What is an experimental study? - ANSWERS-investigates the role of some agent in the
prevention or treatment of a disease.
What are primary and secondary outcomes? - ANSWERS-primary: the main condition
that the trial has been designed to evaluate and the outcome used for the sample size
calculations.
Secondary: not primaries
surrogate outcome: replace heartattack occurrence with cholesterol levels ( efficiency in
follow up, sample size, and cost of the study)
What are the ways to do masking? - ANSWERS-placebo
Sham treatment
What are the two problems due to non compliance? - ANSWERS-1.it results in a
smaller difference between the treatment and comparison group than truly exists
2.non-compliance reduces the statistical power of the study
, What are two ways follow-up is adversely affected? - ANSWERS-dropouts (withdraw
from the study)
losses to follow up (cannot be located or contacted)
What are two types of anaylsis of experimental studies? - ANSWERS-intent-to-treat
assignment approach
Efficacy Analysis
What are the issues that would make it difficult to conduct an experimental study? -
ANSWERS-expensive
many physicians and patients are reluctant to participate
ethical issues
What is a cohort study? - ANSWERS-In a cohort study, healthy subjects are defined
according to their exposure status and followed over time to determine the incidence of
symptoms, disease, or death.
What is the common characteristic for grouping subjects in cohort studies? -
ANSWERS-The common characteristic for grouping subjects is their exposure level.
The unexposed group is called the reference, reference or comparison group
Fixed vs closed vs open cohort? - ANSWERS-The term fixed cohort is used when the
cohort is formed on the basis of an irrevocable event, such as undergoing a medical
procedure.
Closed = no losses to follow up
Open= dynamic population
What are three terms that are used to describe the timing of events in a cohort study in
relation to the initiation of the study? - ANSWERS-Prospective cohort
Retrospective cohort
ambidirectional